Angina (Angina Pectoris) Epidemiology

• According to our secondary analysis, angina pectoris affects an estimated 1.6% of adults in the US, causing chest pain due to reduced blood flow to the heart. This condition can significantly limit physical activity, increase the risk of, and negatively impact daily functioning and overall quality of life.
• Angina pectoris remains a notable public health concern in the US, with prevalence rates increasing markedly with age. Among adults aged 18–44 years, about 0.4% are affected, rising to 1.8% in those aged 45–64 years. The prevalence further climbs to 3.2% for individuals aged 65–74 years and reaches 4.5% in adults aged 75 years and older. This clear age-related pattern highlights the significant burden of coronary heart disease in older populations and underscores the need for targeted prevention and timely diagnosis to reduce the risk of complications such as myocardial infarction and heart failure.
• In France, approximately 6.3% of adults are affected by angina pectoris.
• In Italy, an estimated 5.1% of males and 6.9% of females are living with angina pectoris, a key indicator of underlying coronary artery narrowing. This burden highlights the need for early diagnosis to reduce preventable cardiac events and improve patients’ long-term well-being.
• In Japan, the estimated number of angina pectoris patients in the community was adjusted to account for the high prevalence of vasospastic angina, which is estimated to represent about 40% of all angina cases. This subtype, characterized by coronary artery spasms, highlights the distinct pattern of angina presentation in the Japanese population and the importance of appropriate diagnosis.
• Despite advances in cardiovascular care, there remains a significant unmet need for more accurate and timely diagnosis of angina pectoris, as many patients experience atypical symptoms or silent ischemia, leading to underdiagnosis, and increased risk of severe cardiac events. Improved diagnostic tools and awareness are essential to ensure early detection of angina pectoris.
• Despite a stable prevalence rate, shifts in lifestyle behaviors and increased awareness of cardiovascular health are leading to improved detection of angina pectoris. These factors are shaping epidemiological trends.

DelveInsight’s “Angina pectoris Epidemiology Forecast – 2034” report delivers an in-depth understanding of angina pectoris, historical and forecasted epidemiology trends in the United States, EU4 (Germany, France, Italy, Spain), the United Kingdom, and Japan.

Angina pectoris Epidemiology Understanding

Angina Pectoris Overview

Angina pectoris describes chest pain or discomfort that happens when a portion of the heart muscle doesn’t get enough oxygen-rich blood, most often due to narrowed or blocked coronary arteries. The main underlying issue is usually atherosclerosis, which is the buildup of plaque inside the coronary vessels. However, an individual’s risk is influenced by factors such as age, family history, smoking, diabetes, high cholesterol levels, and high blood pressure. The most common and predictable form, known as stable angina, typically occurs during physical activity or emotional stress. This type of angina is a sign of underlying coronary artery disease and points to an elevated risk of heart attack if left untreated. More serious forms, like unstable angina, are medical emergencies because they involve a sudden reduction in blood flow, often due to plaque rupture or clot formation, which can lead to a heart attack. Another less common type, variant (or vasospastic) angina, is caused by temporary spasms in the coronary arteries and may occur at rest. Unlike stable angina, these unpredictable forms need immediate medical attention to prevent permanent heart damage and other complications.

Angina Pectoris Diagnosis

The diagnosis of angina pectoris relies on a comparative assessment against the characteristics of a healthy, well-perfused heart, which functions efficiently without producing chest pain or related symptoms during normal activity. Clinical evaluation typically involves a detailed patient history, physical examination, electrocardiogram (ECG) at rest and during stress testing, and, when indicated, advanced imaging such as echocardiography, coronary computed tomography angiography (CCTA), or cardiac catheterization to assess the degree of coronary artery narrowing. Key indicators suggestive of angina include episodes of chest discomfort described as pressure, squeezing, or tightness, often triggered by physical exertion or emotional stress and relieved by rest or nitroglycerin. Additional signs may include shortness of breath, sweating, nausea, or pain radiating to the neck, jaw, shoulder, or arm. The severity of angina correlates with the frequency and intensity of symptoms and the degree of underlying coronary artery obstruction. Stress testing, such as exercise ECG or pharmacologic stress imaging, is essential for confirming the diagnosis and evaluating the heart’s response to increased oxygen demand, while coronary angiography remains the gold standard for visualizing significant arterial blockages that may require intervention.

Further details related to diagnosis are provided in the report...

Angina Pectoris Epidemiology

The angina pectoris epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Cases of Angina pectoris, Total Diagnosed Prevalent Cases of Angina pectoris, Gender–specific Diagnosed Prevalent Cases of Angina pectoris, and Age–specific Diagnosed Prevalent Cases of Angina pectoris, Type–specific Diagnosed Prevalent Cases of Angina pectoris in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2020 to 2034.

According to the secondary analysis, cross-sectional data from the US indicate that angina pectoris affects an estimated 1.4% of females and 1.8% of males, underscoring a clear gender gap in cardiovascular burden. These figures highlight the ongoing need for targeted prevention, timely diagnosis, and greater public awareness to reduce avoidable complications and improve heart health outcomes.

A study on angina pectoris identified stable angina as the most prevalent subtype, with an estimated 2 million people affected in France alone. This figure underscores the persistent burden of chronic coronary artery narrowing and highlights the need for better prevention.

Gender-specific patterns in the UK show prevalence rates of 27.9% (28 per 1,000) for males and 24.7% (25 per 1,000) for females, indicating that the burden of angina pectoris is slightly higher among men than women in the population.

In the UK, among the age-specific groups 45–54, 55–64, 65–74, 75–84, and 85 years and older, the largest proportion—approximately 35%—of angina pectoris cases occurs in people aged 45–54. This clear age-related trend shows that the prevalence of angina pectoris rises with advancing age, highlighting the need for targeted prevention and early intervention in older adults.

KOL Views

DelveInsight’s analysts collaborated with over 50 key opinion leaders (KOLs), conducting in-depth interviews with more than 15 experts across the 7MM. To keep pace with dynamic market trends, the team gathered first-hand insights from KOLs and subject matter experts (SMEs) through primary research, addressing data limitations and reinforcing findings from secondary research. These professionals offered valuable input on the angina pectoris landscape, highlighting patient behavior trends, and challenges in access to care. Contributors included experts from renowned institutions such as the McLaren Oakland Hospital, US; Paul Brousse Hospital, France; Robert Koch Institute, Germany; Catholic University of the Sacred Heart, Italy; Hospital La Fe, Spain; University of Glasgow, UK; and Tokyo Women's Medical University, Japan; among others.

According to KOLs from the US, there remains an unmet need to break the persistent cycle of angina pectoris, where periods of chest pain alternate with symptom-free phases. If this pattern continues unchecked, it can eventually lead to complete blockage of the coronary arteries, causing a heart attack and permanent damage to the heart muscle.

As per KOLs from Japan, in recent years chest pain remains the most recognizable clinical indicator of angina pectoris and has been increasingly linked to broader systemic risks, including sudden cardiac events and reduced exercise tolerance in middle-aged and older adults. Additionally, factors such as smoking, hypertension, and elevated cholesterol are strongly associated with higher rates of angina symptoms, as they promote atherosclerotic plaque buildup, reduce coronary blood flow, and trigger episodes of myocardial ischemia.

Scope of the Angina pectoris Epidemiology Report

• The report covers a segment of executive summary, descriptive overview of angina pectoris, explaining its causes, signs and symptoms, and currently available diagnostic algorithms and guidelines.
• Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression, and diagnosis guidelines.
• The report provides an edge for understanding trends, expert insights/KOL views, and patient journeys in the 7MM.
• A detailed review of current challenges in establishing the diagnosis.

Angina Pectoris Insights

• Angina pectoris Patient Population
• Angina pectoris Country-wise Epidemiology Distribution
• Angina pectoris Pipeline Analysis
• Total Prevalent Cases of Angina pectoris
• Total Diagnosed Prevalent Cases of Angina pectoris
• Gender-specific Diagnosed Prevalent Cases of Angina pectoris
• Age-specific Diagnosed Prevalent Cases of Angina pectoris
• Type-specific Diagnosed Prevalent Cases of Angina pectoris

Angina Pectoris Report Key Strengths

• 10 years Forecast
• The 7MM Coverage

Key Questions Answered In The Angina pectoris Epidemiology Report:

Angina pectoris Epidemiology Insights

• What are the disease risk, burden, and diagnosis of angina pectoris?
• What is the historical angina pectoris patient population in the United States, EU4 (Germany, France, Italy, Spain), the United Kingdom, and Japan?
• What would be the forecasted patient population of angina pectoris at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to angina pectoris?
• Out of the above-mentioned countries, which country would have the highest prevalent population of angina pectoris during the forecast period (2025–2034)?
• At what Compound annual growth rate (CAGR) the population is expected to grow across the 7MM during the forecast period (2025–2034)?

Reasons to Buy Angina pectoris Epidemiology Report:

• Insights on patient burden/disease prevalent, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To analyze epidemiological trends of angina pectoris across different regions and assess how these patterns may evolve in the coming years.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis options.

Frequently Asked Questions

1.           What is the forecast period covered in the report?

The angina pectoris epidemiology report for the 7MM covers the forecast period from 2025 to 2034, providing a projection of epidemiology dynamics and trends during this timeframe.

2.           Out of all EU4 countries and the UK, which country had the highest population of angina pectoris cases?

The highest cases of angina pectoris were found in Germany among EU4 and the UK.

3.           How is epidemiological data collected and analyzed for forecasting purposes?

Epidemiological data is collected through surveys, clinical studies, health records, and other sources. It is then analyzed to calculate disease rates, identify trends, and project future disease burdens using mathematical models.

4.           Which severity level accounts for the highest number of prevalent angina pectoris cases across the 7MM?

The highest cases of angina pectoris were found in the stable angina pectoris subtype.