Cerebral Amyloid Angiopathy Pipeline Insight

DelveInsight’s, “Cerebral Amyloid Angiopathy – Pipeline Insights, 2021,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Cerebral Amyloid Angiopathy pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Cerebral Amyloid Angiopathy Understanding

Cerebral Amyloid Angiopathy: Overview

Cerebral amyloid angiopathy (CAA) is a small vessel vasculopathy resulting from the pathologic deposition of amyloid-beta (Aβ) within the media and adventitia of cortical and leptomeningeal arteries, arterioles, capillaries and rarely the venules of the brain. The deposition of amyloid protein in these vessels is associated with fibrinoid necrosis, focal wall fragmentation, and micro aneurysms that predispose the patient to repeated episodes of blood vessel leakage and/or frank hemorrhage.

Symptoms

The symptoms of Cerebral Amyloid Angiopathy include:

  • Intracerebral hemorrhages
  • Microinfarctions
  • Leukoencephalopathy

Diagnosis

The Boston criteria are commonly used when evaluating patients for Cerebral amyloid angiopathy. It is a combination of clinical, pathological, and radiographic criteria that are used to assess the probability of Cerebral Amyloid Angiopathy. Definitive diagnoses can only be made through a postmortem examination of the brain. A “probable CAA” diagnosis can be made during life utilizing imaging or tissue sampling. Gradient-echo magnetic resonance imaging (MRI) is one of the most important techniques used for diagnosis. Gradient-echo magnetic resonance imaging (MRI) demonstrates regions of low-signal blooming artifact caused by iron depositions left by old hemorrhages.

Treatment

Use of antihypertensive medications to prevent hemorrhage recurrence in Cerebral Amyloid Angiopathy. Immunosuppressants are used to treat rarer forms of CAA called CAA-related inflammation and β-amyloid-related angiitis. Use of antithrombotics, such as warfarin, can be associated with intracerebral hemorrhage risk in CAA. 

Cerebral Amyloid Angiopathy Emerging Drugs Chapters

This segment of the Cerebral Amyloid Angiopathy report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Cerebral Amyloid Angiopathy Emerging Drugs

  • Research programme: CNS disorders RNA interference –based therapeutics: Alnylam Pharmaceuticals

Alnylam Pharmaceuticals is developing research programme: CNS disorders RNA interference-based therapeutics which is in preclinical studies.

Further product details are provided in the report……..

Cerebral Amyloid Angiopathy: Therapeutic Assessment

This segment of the report provides insights about the different Cerebral Amyloid Angiopathy drugs segregated based on following parameters that define the scope of the report, such as:


  • Major Players in Cerebral Amyloid Angiopathy

There are approx. 10+ key companies which are developing the therapies for Cerebral Amyloid Angiopathy. The companies which have their Cerebral Amyloid Angiopathy drug candidates in the most advanced stage, i.e. phase II include, Alnylam Pharmaceuticals.


  • Phases

DelveInsight’s report covers around 10+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Cerebral Amyloid Angiopathy pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.


Cerebral Amyloid Angiopathy: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Cerebral Amyloid Angiopathy therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Cerebral Amyloid Angiopathy drugs.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Cerebral Amyloid Angiopathy R&D. The therapies under development are focused on novel approaches to treat/improve Cerebral Amyloid Angiopathy.

Cerebral Amyloid Angiopathy Report Insights

  • Cerebral Amyloid Angiopathy Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Cerebral Amyloid Angiopathy Disease Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Cerebral Amyloid Angiopathy drugs?
  • How many Cerebral Amyloid Angiopathy drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Cerebral Amyloid Angiopathy?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Cerebral Amyloid Angiopathy therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Cerebral Amyloid Angiopathy and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Alnylam Pharmaceuticals

Key Products

  • Research Programme: CNS disorders RNA interference-based therapeutics

 

Introduction

Executive Summary

Cerebral Amyloid Angiopathy: Overview

• Causes

• Mechanism of Action

• Signs and Symptoms

• Diagnosis

• Disease Management

Pipeline Therapeutics

• Comparative Analysis

Therapeutic Assessment

• Assessment by Product Type

• Assessment by Stage and Product Type

• Assessment by Route of Administration

• Assessment by Stage and Route of Administration

• Assessment by Molecule Type

• Assessment by Stage and Molecule Type

Cerebral Amyloid Angiopathy– DelveInsight’s Analytical Perspective

In-depth Commercial Assessment

• Cerebral Amyloid Angiopathy Disease companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Cerebral Amyloid Angiopathy Collaboration Deals

• Company-Company Collaborations (Licensing / Partnering) Analysis

• Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)

• Comparative Analysis

Drug Name: Company Name

• Product Description

• Research and Development

• Product Development Activities

Mid Stage Products (Phase II)

• Comparative Analysis

Drug Name: Company Name

• Product Description

• Research and Development

• Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I)

• Comparative Analysis

Drug Name: Company Name

• Product Description

• Research and Development

• Product Development Activities

Drug profiles in the detailed report…..

Pre-clinical and Discovery Stage Products

• Comparative Analysis

Research Programme: CNS disorders RNA interference-based Therapeutics: Alnylam Pharmaceuticals

• Product Description

• Research and Development

• Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

• Comparative Analysis

Cerebral Amyloid Angiopathy Key Companies

Cerebral Amyloid Angiopathy Key Products

Cerebral Amyloid Angiopathy- Unmet Needs

Cerebral Amyloid Angiopathy- Market Drivers and Barriers

Cerebral Amyloid Angiopathy- Future Perspectives and Conclusion

Cerebral Amyloid Angiopathy Analyst Views

Cerebral Amyloid Angiopathy Key Companies

Appendix

List of Table

Table 1 Total Products for Cerebral Amyloid Angiopathy

Table 2 Late Stage Products

Table 3 Mid Stage Products

Table 4 Early Stage Products

Table 5 Pre-clinical & Discovery Stage Products

Table 6 Assessment by Product Type

Table 7 Assessment by Stage and Product Type

Table 8 Assessment by Route of Administration

Table 9 Assessment by Stage and Route of Administration

Table 10 Assessment by Molecule Type

Table 11 Assessment by Stage and Molecule Type

Table 12 Inactive Products

List of Figures

Figure 1 Total Products for Cerebral Amyloid Angiopathy

Figure 2 Late Stage Products

Figure 3 Mid Stage Products

Figure 4 Early Stage Products

Figure 5 Preclinical and Discovery Stage Products

Figure 6 Assessment by Product Type

Figure 7 Assessment by Stage and Product Type

Figure 8 Assessment by Route of Administration

Figure 9 Assessment by Stage and Route of Administration

Figure 10 Assessment by Molecule Type

Figure 11 Assessment by Stage and Molecule Type

Figure 12 Inactive Products

• Alnylam Pharmaceuticals

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