Cholangiocarcinoma Epidemiology

DelveInsight's "Cholangiocarcinoma (CCA)- Epidemiology Forecast-2034" report delivers an in-depth understanding of the Cholangiocarcinoma, historical and forecasted epidemiology as well as the Cholangiocarcinoma trends in the United States, EU-5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

Geography Covered

• The United States
• EU-5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Cholangiocarcinoma (CCA) Understanding

The DelveInsight’s Cholangiocarcinoma epidemiology report gives a thorough understanding of Cholangiocarcinoma. Cholangiocarcinoma is a type of cancer that forms in the slender tubes (bile ducts) that carry the digestive fluid bile. Bile ducts connect your liver to your gallbladder and to your small intestine. Cholangiocarcinoma (CCA) tumors can arise from anywhere in the biliary tract and may be difficult to identify based on histopathologic analysis alone. Cholangiocarcinoma can be anatomically differentiated into intrahepatic CCA (ICC) and extrahepatic CCA (ECC).

Unfortunately, the outlook is bleak. Most patients have an advanced or incurable illness when they are diagnosed, leaving systemic therapy as their sole choice for treatment. It is generally known that subgroups vary in their tumor biology and clinical presentation in addition to their varied etiological sources. Surgery may be curative for individuals with resectable illness when they first arrive, although these patients make up a small percentage with substantial recurrence rates. Additionally, the recurrence patterns often prohibit additional curative resection.

The best method for extending survival is still total surgical resection (R0); however, disease recurrence is not unheard of. Furthermore, patient comorbidities sometimes precluded surgical intervention, even if it could technically be done. Therefore, in order to increase survival in such a population, reduced morbidity interventional procedures must be developed. Early research on the genetic pathophysiology of CCAs concentrated on determining the carcinogenic function of certain genes, which were frequently discovered to be mutated in other cancers or altered by copy number changes. Studies have demonstrated that the genetic profiles of intrahepatic cholangiocarcinoma (CCA), extrahepatic cholangiocarcinoma, and gallbladder cancers are diverse; in fact, 50% of patients have actionable mutations such as FGFR, IDH1, HER2, and BRAF.

For a definitive diagnosis, patients usually undergo endoscopic retrograde cholangiopancreatography and procedures such as cytology, brushing, FISH (fluorescence in situ hybridization)-polisomy, biopsy, ultrasonography, choledochoscopy, cholangioscopy, chromoendoscopy, confocal endoscopy, narrow-band imaging. MRI, CT, endoscopic ultrasonography, or 18FDG PET-CT cannot definitively demonstrate the stricture’s neoplastic nature.

Surgery with complete resection represents the only treatment for CCA with curative intent. Other treatment approaches may include liver transplantation which is associated with rapid tumor recurrence and low survival, and it has historically not been recommended as a treatment for unresectable CCA. Chemotherapy for patients presenting with unresectable or metastatic CCA, systemic chemotherapy remains the mainstay palliative treatment modality, and the role of adjuvant chemotherapy is not clearly defined in CCA, but for patients with local recurrence after resectioning pCCA, chemotherapy has been recommended.

Cholangiocarcinoma (CCA) Epidemiology

The epidemiology section provides insights about the historical and current Cholangiocarcinoma patient pool and forecasted trends for individual seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

The disease epidemiology covered in the report provides a historical as well as forecasted Cholangiocarcinoma epidemiology scenario in the 7MM covering the United States, EU-5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2021 to 2034.

In the year 2021, the total diagnosed incident cases of CCA were 46,466 in the 7MM which are expected to grow during the study period, i.e., 2021-2034.

The disease epidemiology covered in the report provides historical as well as forecasted Cholangiocarcinoma epidemiology [segmented as Total Diagnosed-incidence Cases of Cholangiocarcinoma, Total Type-specific Cases of Cholangiocarcinoma, Total Age-specific Cases of Cholangiocarcinoma, Total Stage-specific Cases of Cholangiocarcinoma, Total Mutation-specific Cases of Cholangiocarcinoma, and Total Treated Cases (across lines) of Cholangiocarcinoma] in the 7MM covering the United States, EU-5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2021 to 2034. 

Country Wise- Cholangiocarcinoma (CCA) Epidemiology

The epidemiology segment also provides the Cholangiocarcinoma epidemiology data and findings across the United States, EU-5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

• According to the DelveInsight, in the year 2021, the total diagnosed incident cases of CCA were 10,034 in the United States which are expected to grow during the study period, i.e., 2021-2034.
• The highest number of total incident cases of CCA was observed in Italy among the EU5 countries with 6,489 cases in 2021 which are expected to grow during the study period, i.e., 2021-2034.
• In the year 2021, the total diagnosed incident cases of CCA were 16,004 in Japan which are expected to grow during the study period, i.e., 2021-2034.

KOL- Views

To keep up with the current Cholangiocarcinoma patient pool and forecasted trend, we take KOLs and SMEs ' opinions working in the Cholangiocarcinoma domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate the patient pool and forecasted trend.

Scope of the Report

• The report covers the descriptive overview of Cholangiocarcinoma, explaining their causes, symptoms, pathophysiology, and genetic basis.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU-5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
• The report assesses the disease risk and burden and highlights the unmet needs of Cholangiocarcinoma.
• The report helps to recognize the growth opportunities in the 7MM concerning the patient population.
• The report provides the segmentation of the disease epidemiology for 7MM total diagnosed-incident cases of Cholangiocarcinoma, total age-specific cases of Cholangiocarcinoma, total mutation-specific cases of Cholangiocarcinoma, total stage-specific cases of Cholangiocarcinoma, and total treated cases (across lines) of Cholangiocarcinoma in the 7MM covering the United States, EU-5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2021 to 2034.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Cholangiocarcinoma R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
• A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for Cholangiocarcinoma.
• Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends, and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Cholangiocarcinoma (CCA) Report Key Strengths

• 11 Years Forecast
• 7MM Coverage
• Cholangiocarcinoma Epidemiology Segmentation

Key Questions

Epidemiology Insights:

• What are the disease risk, burden, and regional/ethnic differences of Cholangiocarcinoma?
• What are the key factors driving the epidemiology trend for seven major markets covering the United States, EU-5 (Germany, Spain, France, Italy, UK), and Japan?
• What is the historical Cholangiocarcinoma patient pool in seven major markets covering the United States, EU-5 (Germany, Spain, France, Italy, UK), and Japan?
• What would be the forecasted patient pool of Cholangiocarcinoma in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
• Where will be the growth opportunities in the 7MM concerning the patient population about Cholangiocarcinoma?
• Out of all 7MM countries, which country would have the highest prevalent population of Cholangiocarcinoma during the forecast period (2025-2034)?
• At what CAGR the patient population is expected to grow by 7MM during the forecast period (2025-2034)?

Reasons to buy

• The report will help in developing business strategies by understanding trends shaping and driving the Cholangiocarcinoma Disease market
• To understand the future market competition in the Cholangiocarcinoma Disease market
• Organize sales and marketing efforts by identifying the best opportunities for Cholangiocarcinoma Disease in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom), and Japan
• Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
• Organize sales and marketing efforts by identifying the best opportunities for the Cholangiocarcinoma Disease market
• To understand the future market competition in the Cholangiocarcinoma Disease market