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Complement C1s Inhibitors Pipeline Insight

DelveInsight’s, “Complement C1s Inhibitors – Pipeline Insight, 2021,” report provides comprehensive insights about 4+ companies and 4+ pipeline drugs in  Complement C1s Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Complement C1s Inhibitors Understanding

Complement C1s Inhibitors: Overview

C1 inhibitor is a broad-spectrum serpin that inhibits the activated forms of several members of the complement pathway (C1r and C1s), the contact system (FXIIa, FXIa, and kallikrein) as well as fibrinolytic proteases (plasmin, tPA and uPA). C1-INH binds covalently to C1r and C1s, leading to dissociation of the C1 macromolecular complex and inhibition of the enzymatic actions of C1r and C1s. Several C1 inhibitors targeting C1s are progressing towards clinical trials.

 

"Complement C1s Inhibitors - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the  Complement C1s Inhibitors pipeline landscape is provided which includes the disease overview and  Complement C1s Inhibitors treatment guidelines. The assessment part of the report embraces, in depth  Complement C1s Inhibitors commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology,  Complement C1s Inhibitors collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence  Complement C1s Inhibitors R&D. The therapies under development are focused on novel approaches to treat/improve  Complement C1s Inhibitors.

Complement C1s Inhibitors Emerging Drugs Chapters

This segment of the  Complement C1s Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

 

Complement C1s Inhibitors Emerging Drugs

 

Sutimlimab: Bioverativ

Sutimlimab, formerly known as BIVV009 or TNT009, is an investigational monoclonal antibody that causes selective blockade of complement C1, a protein with an integral role in the classical complement pathway. This pathway is overactivated in cold agglutinin disease (CAD). By blocking C1, sutimlimab treats the underlying cause of hemolysis, thus preventing hemolytic anemia and reducing the disease burden. The U.S. Food and Drug Administration (FDA) has issued a complete response to Sanofi’s application requesting that its investigational therapy sutimlimab be approved for treating hemolysis — the breakdown of red blood cells — in adults with cold agglutinin disease (CAD). The U.S. Food and Drug Administration (FDA) has issued a complete response to Sanofi’s application requesting that its investigational therapy sutimlimab be approved for treating hemolysis — the breakdown of red blood cells — in adults with cold agglutinin disease (CAD).  While the complete response letter did not report any issues regarding clinical data on the therapy’s safety and effectiveness, which were provided in Sanofi’s biologics license application, it referred to “certain deficiencies” detected by the agency during a pre-license inspection of a third-party manufacturing facility.

Further product details are provided in the report……..

Complement C1s Inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different  Complement C1s Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in  Complement C1s Inhibitors

There are approx. 4+ key companies which are developing the therapies for  Complement C1s Inhibitors. The companies which have their  Complement C1s Inhibitors drug candidates in the most advanced stage, i.e. preregistration include Bioverativ.

Phases

DelveInsight’s report covers around 4+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

 

Complement C1s Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Subcutaneous
  • Intravenous
  • Intramuscular
  • Molecule Type

 

Products have been categorized under various Molecule types such as

  • Peptides
  • Polymer
  • Small molecule
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Complement C1s Inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses  Complement C1s Inhibitors therapeutic drugs key players involved in developing key drugs.

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging  Complement C1s Inhibitors drugs.

Complement C1s Inhibitors Report Insights

  • Complement C1s Inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Complement C1s Inhibitors Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing  Complement C1s Inhibitors drugs?
  • How many  Complement C1s Inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of  Complement C1s Inhibitors?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the  Complement C1s Inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for  Complement C1s Inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Complement C1s Inhibitors: Overview

  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Late Stage Products (Preregistration)

  • Comparative Analysis

Sutimlimab: Bioverativ

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

SAR 445088: Sanofi

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Complement C1s Inhibitors Key Companies

Complement C1s Inhibitors Key Products

Complement C1s Inhibitors- Unmet Needs

Complement C1s Inhibitors- Market Drivers and Barriers

Complement C1s Inhibitors- Future Perspectives and Conclusion

Complement C1s Inhibitors Analyst Views

Complement C1s Inhibitors Key Companies

Appendix

List of Table

Table 1: Total Products for Complement C1s Inhibitors

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type                                              

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Complement C1s Inhibitors

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type                                                                       

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products

• Bioverativ
• CSL Behring
• Pharming Group NV
• Sanofi

 

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