Complex Regional Pain Syndrome

DelveInsight's 'Complex Regional Pain Syndrome (CRPS) - Market Insights, Epidemiology and Market Forecast-2028' report delivers an in-depth understanding of the disease, historical and forecasted epidemiology as well as the market trends of Complex Regional Pain Syndrome (CRPS) in the United States, EU5 (Germany, Spain, Italy, France and the United Kingdom), and Japan.

The Report provides the current treatment practices, emerging drugs, a market share of the individual therapies, the current and forecasted market size of Complex Regional Pain Syndrome (CRPS) from 2017 to 2028 segmented by seven major markets. The Report also covers current treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assess the underlying potential of the market.


Geography Covered

The United States

EU5 (Germany, France, Italy, Spain and the United Kingdom)

Japan


Study Period: 2017-2028


Complex Regional Pain Syndrome (CRPS) - Disease Understanding and Treatment Algorithm

According to Classification of Chronic Pain (Merskey and Bogduk 2011) of the IASP and fourth edition of CRPS guidelines, published in 2013, Harden et al. state that “CRPS-I is a syndrome characterized by a continuing (spontaneous and/or evoked) regional pain that is seemingly disproportionate in time or degree to the usual course of pain after trauma or another lesion. The pain is regional (not in a specific nerve territory or dermatome) and usually has a distal predominance of abnormal sensory, motor, sudomotor, vasomotor/edema and/or trophic findings. The syndrome shows variable progression over time. CRPS-I occurs after any form of trauma, particularly a fracture or soft tissue lesion. CRPS-II occurs after nerve damage.” There is great heterogeneity of symptoms endorsed by patients with CRPS and the clinical course varies however, the pain is the main symptom of CRPS. The pain spreads regionally, beyond a single dermatome or original insults, for example from hand to forearm. From the original International Association for the Study of Pain (IASP) criteria, Harden et al. developed the Budapest Criteria. This defined CRPS as a progressive array of painful conditions characterized by regional pain disproportionate to the inciting event in time and degree; a distal predominance of sensory, motor, sudomotor, vasomotor, and/or trophic findings; and an inability to better explain pathology by alternative diagnoses. CRPS-I, previously named reflex sympathetic dystrophy, is characterized by nociceptive pain while CRPS-II, previously named causalgia, is characterized by neuropathic pain. An additional subtype, CRPS-NOS (CRPS not otherwise specified), has been identified as CRPS which partially meets criteria but is not better explained by other conditions.

The DelveInsight Complex Regional Pain Syndrome (CRPS) market report gives the thorough understanding of the Complex Regional Pain Syndrome (CRPS) by including details such as disease definition, causes, symptoms, risk factors, and pathophysiology and diagnostic trends. It also provides treatment algorithms and treatment guidelines for Complex Regional Pain Syndrome (CRPS) in the US, Europe, and Japan.


Complex Regional Pain Syndrome (CRPS) Epidemiology

The Complex Regional Pain Syndrome (CRPS) epidemiology division provide insights about a historical and current patient pool and forecasted trend for every 7 major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (Total Prevalent cases Population of Complex Regional Pain Syndrome (CRPS), Gender-specific Incidence Cases of Complex Regional Pain Syndrome (CRPS), Type specific Prevalent Cases of Complex Regional Pain Syndrome (CRPS), Number of CRPS cases in Associated Triggered Factors, Diagnosed and Treatable Cases of Complex Regional Pain Syndrome (CRPS)) scenario of Complex Regional Pain Syndrome (CRPS) in the 7MM covering United States, EU5 countries (Germany, Spain, Italy, France and United Kingdom) and Japan from 2017-2028.

A retrospective cohort study by de Mos et al., in 2007, is the first ever population representative European epidemiological study. Subsequently, cases were validated for the diagnosis of CRPS with original specialist letters and information from an inquiry of general practitioners. The estimated overall new cases of CRPS was 26.2 per 100,000 person-years (95% CI: 23.0-29.7). The incidence rate of CRPS did not change significantly over time between 1996 and 2005. The disease occurrence varied profoundly with age, where the highest incidence rate was observed in the group 61-70 years of age with a mean age at diagnosis of 52.7 years. Gender-specific reporting of cases, based on the reconfirmed diagnoses, for females and males, were 40.4 and 11.9 per 100,000 person-years, respectively i.e., Females were affected at least three times more often than males (RR: 3.4, 95% CI: 2.9-3.9). The most common precipitating event for CRPS was a fracture, followed by a contusion/sprain. Upper extremities were more often affected than lower extremities, whereas the right side and left side of the body were affected with the same frequency


Complex Regional Pain Syndrome (CRPS) Drug Chapters

This segment of the Complex Regional Pain Syndrome (CRPS) report encloses the detailed analysis of late-stage (Phase-III-I) pipeline drugs. It also helps to understand the clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

According to CRPS-Practical Diagnostic and Treatment Guidelines, 4th Edition - the USA, Medications trialed specifically for CRPS include calcitonin and bisphosphonates, corticosteroids, and most recently, intravenous immunoglobulin (IVIG). Treatments better studied in other related neuralgias include tricyclics, gabapentin and pregabalin, carbamazepine, opioids, clonidine, nifedipine, a-adrenergic antagonists, 5% lidocaine patch, and topical capsaicin. Interventional therapies such as nerve blocks, drug infusions, and implantable pain treatment devices have all been advocated for the treatment of CRPS. As the mechanisms of CRPS are better understood, mechanistic-based treatments should be forthcoming; but in the meanwhile, different interventional and non-interventional treatment modalities are applied empirically in a timely manner to facilitate reanimation of the affected extremity. Various blockade therapies such as sympathetic nerve blocks (SNBs), IV regional techniques (IVRAs), “other” blocks including somatic and spinal infusions, neurolytic sympathetic blockade, and implantable therapies including neurostimulators and intrathecal pumps have been available.

Currently, the treatment of CRPS is restricted to palliative care and symptom-based interventions such as Non-opioid analgesics (Paracetamol, NSAIDs, Nefopam etc.), Weak opioid analgesics (Tramadol, Codeine/Acetaminophen, Opium/PCM etc.), Strong opioid analgesics, Co-analgesics (Corticosteroids, Antiepileptics, Antidepressants, Tricyclic Antidepressants, SNRIs, Bisphosphonate, IV Bisphosphonate, Calcitonin, Ketamine etc.), Local treatment (Joint infusion of corticosteroids, Lidocaine cream, Lidocaine patch, Capsaicin, NSAIDs etc.) and others (including Physiotherapy, surgery, Psychological interventions etc.)

The process of developing preventive measures or defining the optimal treatment of a disease is usually based on an understanding of the disease's epidemiology, identifying the pathophysiology, and targeting the etiological factors and symptoms individually. Unfortunately, in the case of CRPS, information is inadequate at many of these levels. The paucity of available randomized trials of pharmacotherapy specifically on CRPS resulted in a pragmatic approach for all health care providers.

To meet the increasing demand for the treatment of Complex Regional Pain Syndrome (CRPS), companies have shifted their focus towards the development of targeted therapies. The expected launch of potential therapies may increase the market size in the coming years, assisted by an increase in the Prevalence population of Complex Regional Pain Syndrome (CRPS) and awareness of the disease. The overall dynamics of Complex Regional Pain Syndrome (CRPS) market is anticipated to change in the coming years owing to the expected launch of emerging therapies such as Neridronate (Abiogen Pharma/Grünenthal), BHV-5000 (BioHeaven Pharmaceuticals), PPP001 (Tetra Bio-Pharma) and AXS-02 (Axsome Therapeutics) and some others, will significantly increase the market during the forecast period (2019-2028).  


Complex Regional Pain Syndrome (CRPS) Market Outlook

The Complex Regional Pain Syndrome (CRPS) market outlook of the report helps to build the detailed comprehension of the historic, current and forecasted trend of the market by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a thorough detail of market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the market of Complex Regional Pain Syndrome (CRPS) in 7MM is expected to change from 2019-2028.


Complex Regional Pain Syndrome (CRPS) Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the market or will get launched in the market during the study period from 2017-2028. The analysis covers market uptake by drugs; patient uptake by therapies and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

The expected launch of therapies for Complex Regional Pain Syndrome (CRPS) such as Neridronate (Abiogen Pharma/Grünenthal) is the first in class, non-opioid therapeutic, and being developed as an intravenous infusion for the treatment of CRPS in the US and Europe (except Italy). It is expected to hold major market share by2028


Complex Regional Pain Syndrome (CRPS) Report Insights

• Patient Population

• Therapeutic Approaches

• Market Size and Trends

• Market Opportunities

• Impact of upcoming Therapies

• Complex Regional Pain Syndrome (CRPS) Report Key Strengths


10 Year Forecast

• 7MM Coverage

• Epidemiology Segmentation

• Drugs Uptake

• Highly Analyzed Market

• Key Cross Competition

• Complex Regional Pain Syndrome (CRPS) Report Assessment


Current Treatment Practices

• Unmet Needs

• Market Attractiveness

• Market Drivers and Barriers


Key Benefits

• This DelveInsight report will help to develop Business Strategies by understanding the trends shaping and driving Complex Regional Pain Syndrome (CRPS) market

• Organize sales and marketing efforts by identifying the best opportunities for Complex Regional Pain Syndrome (CRPS) market

• To understand the future market competition in the Complex Regional Pain Syndrome (CRPS) market.

1             Key Insights


2             Complex Regional Pain Syndrome (CRPS): Market Overview at a Glance 


2.1         Total Market Share (%) Distribution of Complex Regional Pain Syndrome (CRPS) in 2017


2.2         Total Market Share (%) Distribution of Complex Regional Pain Syndrome (CRPS) in 2028


3             Complex Regional Pain Syndrome (CRPS): Disease Background and Overview  


3.1         Introduction 


3.2         Symptoms          


3.3         Clinical presentations


3.4         Natural course of CRPS


3.5         Classification 


3.6         Pathophysiology


3.7         Diagnosis


3.7.1     Differential diagnosis


3.8         Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 4th Edition - the USA 


3.9         UK guidelines for diagnosis, referral, and management in primary and secondary care for CRPS in adults


3.10       Japanese CRPS diagnostic criteria


4             Epidemiology and Patient Population 


4.1         Key Findings


5             Total Cases of Complex Regional Pain Syndrome in 7MM  


6             United States Epidemiology


6.1         Assumptions and Rationale 


6.2         Prevalent cases of Complex Regional Pain Syndrome in the US


6.3         Gender specific Cases of Complex Regional Pain Syndrome in the United States


6.4         Diagnosed Cases of CRPS in the United States


6.5         Type Specific Cases of CRPS in the United States


6.6         Number of CRPS cases in Associated Triggered Factors in the US


7             EU5 Epidemiology


7.1         Germany Epidemiology


7.1.1     Prevalent cases of Complex Regional Pain Syndrome in Germany


7.1.2     Gender specific Cases of Complex Regional Pain Syndrome in Germany


7.1.3     Diagnosed Cases of CRPS in Germany


7.1.4     Type Specific Cases of CRPS in Germany


7.1.5     Number of CRPS cases in Associated Triggered Factors in Germany


7.2         France Epidemiology


7.2.1     Total Prevalent cases of Complex Regional Pain Syndrome in France


7.2.2     Gender specific Cases of Complex Regional Pain Syndrome in France


7.2.3     Diagnosed Cases of CRPS in France


7.2.4     Type Specific Cases of CRPS in France


7.2.5     Number of CRPS cases in Associated Triggered Factors in France


7.3         Italy Epidemiology


7.3.1     Total Prevalent cases of Complex Regional Pain Syndrome in Italy


7.3.2     Gender specific Cases of Complex Regional Pain Syndrome in Italy


7.3.3     Diagnosed Cases of CRPS in Italy


7.3.4     Type Specific Cases of CRPS in Italy


7.3.5     Number of CRPS cases in Associated Triggered Factors in Italy


7.4         Spain Epidemiology


7.4.1     Total Prevalent cases of Complex Regional Pain Syndrome in Spain 


7.4.2     Gender specific Cases of Complex Regional Pain Syndrome in Spain 


7.4.3     Diagnosed Cases of CRPS in Spain 


7.4.4     Type Specific Cases of CRPS in Spain 


7.4.5     Number of CRPS cases in Associated Triggered Factors in Spain 


7.5         United Kingdom Epidemiology


7.5.1     Total Prevalent cases of Complex Regional Pain Syndrome in the UK 


7.5.2     Gender specific Cases of Complex Regional Pain Syndrome in the UK 


7.5.3     Diagnosed Cases of CRPS in the UK 


7.5.4     Type Specific Cases of CRPS in the UK 


7.5.5     Number of CRPS cases in Associated Triggered Factors in the UK 


8             Japan Epidemiology


8.1         Assumptions and Rationale 


8.1.1     Total Prevalent cases of Complex Regional Pain Syndrome in Japan 


8.1.2     Gender specific Cases of Complex Regional Pain Syndrome in Japan 


8.1.3     Diagnosed Cases of CRPS in Japan 


8.1.4     Type Specific Cases of CRPS in Japan 


8.1.5     Number of CRPS cases in Associated Triggered Factors in Japan 


9             Treatment and Management of CRPS


9.1         Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 4th Edition - the USA 


9.2         UK guidelines for diagnosis, referral, and management in primary and secondary care for CRPS in adults


10          Unmet Needs


11          Emerging Therapies


11.1       Key Cross Competition 


11.2       Neridronate: Abiogen Pharma/Grünenthal


11.2.1   Product Description 


11.2.2   Other Developmental Activities


11.2.3   Clinical Development


11.2.4   Safety and Efficacy


11.2.5   Product Profile


12          Complex Regional Pain Syndrome (CRPS): 7MM Market Analysis


12.1       Key Findings


12.1       Market Size of Complex Regional Pain Syndrome in 7MM  


13          United States: Market Outlook


13.1       United States Market Size 


13.1.1   Total Market size of Complex Regional Pain Syndrome


13.1.2   Market Size of Complex Regional Pain Syndrome by Therapies in the US


14          EU-5 countries: Market Outlook


14.1       Germany Market Size 


14.1.1   Total Market size of Complex Regional Pain Syndrome


14.1.2   Market Size of Complex Regional Pain Syndrome by Therapies in Germany


14.2       France Market Size 


14.2.1   Total Market size of Complex Regional Pain Syndrome


14.2.2   Market Size of Complex Regional Pain Syndrome by Therapies in France


14.3       Italy Market Size 


14.3.1   Total Market size of Complex Regional Pain Syndrome


14.3.2   Market Size of Complex Regional Pain Syndrome by Therapies in Italy


14.4       Spain Market Size 


14.4.1   Total Market size of Complex Regional Pain Syndrome


14.4.2   Market Size of Complex Regional Pain Syndrome by Therapies in Spain 


14.5       United Kingdom Market Size 


14.5.1   Total Market size of Complex Regional Pain Syndrome


14.5.2   Market Size of Complex Regional Pain Syndrome by Therapies in the UK 


15          Japan Market Outlook


15.1       Japan Market Size 


15.1.1   Total Market size of Complex Regional Pain Syndrome


15.1.2   Market Size of Complex Regional Pain Syndrome by Therapies in Japan 


16          Market Drivers


17          Market Barriers


18          Appendix


18.1       Report Methodology


19          DelveInsight Capabilities


20          Disclaimer


21          About DelveInsight 

Table 1 Comparison of CRPS Types


Table 2 Common characteristics of CRPS


Table 3 International association for the study of pain (IASP) diagnostic criteria for CRPS I and CRPS II


Table 4 Proposed modified research diagnostic criteria for CRPS by Bruehl et al


Table 5 IASP clinical diagnostic criteria for CRPS - Budapest Criteria (2012)


Table 6 Possible mechanisms involved in complex regional pain syndrome


Table 7 Summary of pathophysiologic mechanisms that may contribute to CRPS


Table 8 Differential Diagnosis


Table 9 Technical investigations helpful to exclude a differential diagnosis


Table 10              Differential Diagnosis


Table 11              Original International Association for the Study of Pain (Orlando) diagnostic criteria for complex regional pain syndrome


Table 12              Factors (and factor loadings) resulting from principal components factor analysis of diagnostic and associated signs and symptoms of complex regional pain syndrome


Table 13              Clinical diagnostic criteria for complex regional pain syndrome


Table 14              Summary of sensitivity and specificity of the clinical and research criteria


Table 15              Diagnosis of CRPS - Recommendations


Table 16              Referral - Recommendations


Table 17              Surgical practice - Diagnostic Recommendations


Table 18              Diagnosis of CRPS in emergency medicine - Recommendations


Table 19              The Veldman criteria


Table 20              Factors (and factor loadings) resulting from factor analysis of CRPS-related signs/symptoms


Table 21              Japanese CRPS diagnostic criteria for clinical purposes


Table 22              Total Cases of Complex Regional Pain Syndrome (CRPS) in 7MM (2017-2028)


Table 23              Total Cases of CRPS in the US (2017-2028)


Table 24              Gender specific Cases of Complex Regional Pain Syndrome in the US (2017-2028)


Table 25              Diagnosed Cases of CRPS in the US (2017-2028)


Table 26              Type Specific Diagnosed Cases of CRPS in the US (2017-2028)


Table 27              Number of CRPS cases in Associated Triggered Factors in the US (2017-2028)


Table 28              Total Cases of CRPS in Germany (2017-2028)


Table 29              Gender specific Cases of Complex Regional Pain Syndrome in Germany (2017-2028)


Table 30              Diagnosed Cases of CRPS in Germany (2017-2028)


Table 31              Type Specific Diagnosed Cases of CRPS in Germany (2017-2028)


Table 32              Number of CRPS cases in Associated Triggered Factors in Germany (2017-2028)


Table 33              Total Cases of CRPS in France (2017-2028)


Table 34              Gender specific Cases of Complex Regional Pain Syndrome in France (2017-2028)


Table 35              Diagnosed Cases of CRPS in France (2017-2028)


Table 36              Type Specific Diagnosed Cases of CRPS in France (2017-2028)


Table 37              Number of CRPS cases in Associated Triggered Factors in France (2017-2028)


Table 38              Total Cases of CRPS in Italy (2017-2028)


Table 39              Gender specific Cases of Complex Regional Pain Syndrome in Italy (2017-2028)


Table 40              Diagnosed Cases of CRPS in Italy (2017-2028)


Table 41              Type Specific Diagnosed Cases of CRPS in Italy (2017-2028)


Table 42              Number of CRPS cases in Associated Triggered Factors in Italy (2017-2028)


Table 43              Total Cases of CRPS in Spain (2017-2028)


Table 44              Gender specific Cases of Complex Regional Pain Syndrome in Spain (2017-2028)


Table 45              Diagnosed Cases of CRPS in Spain (2017-2028)


Table 46              Type Specific Diagnosed Cases of CRPS in Spain (2017-2028)


Table 47              Number of CRPS cases in Associated Triggered Factors in Spain (2017-2028)


Table 48              Total Cases of CRPS in the UK (2017-2028)


Table 49              Gender specific Cases of Complex Regional Pain Syndrome in the UK (2017-2028)


Table 50              Diagnosed Cases of CRPS in the UK (2017-2028)


Table 51              Type Specific Diagnosed Cases of CRPS in the UK (2017-2028)


Table 52              Number of CRPS cases in Associated Triggered Factors in the UK (2017-2028)


Table 53              Total Cases of CRPS in Japan (2017-2028)


Table 54              Gender specific Cases of Complex Regional Pain Syndrome in Japan (2017-2028)


Table 55              Diagnosed Cases of CRPS in Japan (2017-2028)


Table 56              Type Specific Diagnosed Cases of CRPS in Japan (2017-2028)


Table 57              Number of CRPS cases in Associated Triggered Factors in Japan (2017-2028)


Table 58              Pharmacotherapy guide


Table 59              Management of suspected or confirmed CRPS - Recommendations


Table 60              Therapeutic approaches


Table 61              Yellow Flags


Table 62              Examples of CRPS-specific rehabilitation techniques


Table 63              Occupational therapy and physiotherapy- Recommendations


Table 64              Surgical practice - Management Recommendations


Table 65              Surgery to amputate the CRPS-affected limb - Recommendations


Table 66              Management and referral of CRPS in emergency medicine - Recommendations


Table 67              Key Cross Emerging Therapies (III - II)


Table 68              Neridronate, Clinical Trial Description, 2019


Table 69                Market Size of Complex Regional Pain Syndrome in 7MM in USD Million (2017-2028)


Table 70              The US Market Size of Complex Regional Pain Syndrome (CRPS) in USD Million (2017-2028)


Table 71              Market Size of CRPS by therapies in the US in USD Million (2017-2028)


Table 72              Germany Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 73              Market Size of CRPS by therapies in Germany in USD Million (2017-2028)


Table 74              France Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 75              Market Size of CRPS by therapies in France in USD Million (2017-2028)


Table 76              Italy Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 77              Market Size of CRPS by therapies in Italy in USD Million (2017-2028)


Table 78              Spain Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 79              Market Size of CRPS by therapies in Spain in USD Million (2017-2028)


Table 80              UK Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 81              Market Size of CRPS by therapies in the UK in USD Million (2017-2028)


Table 82              Japan Market Size of Complex Regional Pain Syndrome in USD Million (2017-2028)


Table 83              Market Size of CRPS by therapies in Japan in USD Million (2017-2028)

Figure 1               Complex regional pain syndrome - CRPS


Figure 2               Typical features of a patient with complex regional pain syndrome


Figure 3               Model for the development of complex regional pain syndrome (CRPS) from nerve injury


Figure 4               Speculative model of interacting mechanisms involved in the development of CRPS


Figure 5               Total Cases of Complex Regional Pain Syndrome in 7MM (2017-2028)


Figure 6               Total Cases of CRPS in the US (2017-2028)


Figure 7               Gender specific Cases of Complex Regional Pain Syndrome in the US (2017-2028)


Figure 8               Diagnosed Cases of CRPS in the US (2017-2028)


Figure 9               Type Specific Diagnosed Cases of CRPS in the US (2017-2028)


Figure 10             Number of CRPS cases in Associated Triggered Factors in the US (2017-2028)


Figure 11             Total Cases of CRPS in Germany (2017-2028)


Figure 12             Gender specific Cases of Complex Regional Pain Syndrome in Germany (2017-2028)


Figure 13             Diagnosed Cases of CRPS in Germany (2017-2028)


Figure 14             Type Specific Diagnosed Cases of CRPS in Germany (2017-2028)


Figure 15             Number of CRPS cases in Associated Triggered Factors in Germany (2017-2028)


Figure 16             Total Cases of CRPS in France (2017-2028)


Figure 17             Gender specific Cases of Complex Regional Pain Syndrome in France (2017-2028)


Figure 18             Diagnosed Cases of CRPS in France (2017-2028)


Figure 19             Type Specific Diagnosed Cases of CRPS in France (2017-2028)


Figure 20             Number of CRPS cases in Associated Triggered Factors in France (2017-2028)


Figure 21             Total Cases of CRPS in Italy (2017-2028)


Figure 22             Gender specific Cases of Complex Regional Pain Syndrome in Italy (2017-2028)


Figure 23             Diagnosed Cases of CRPS in Italy (2017-2028)


Figure 24             Type Specific Diagnosed Cases of CRPS in Italy (2017-2028)


Figure 25             Number of CRPS cases in Associated Triggered Factors in Italy (2017-2028)


Figure 26             Total Cases of CRPS in Spain (2017-2028)


Figure 27             Gender specific Cases of Complex Regional Pain Syndrome in Spain (2017-2028)


Figure 28             Diagnosed Cases of CRPS in Spain (2017-2028)


Figure 29             Type Specific Diagnosed Cases of CRPS in Spain (2017-2028)


Figure 30             Number of CRPS cases in Associated Triggered Factors in Spain (2017-2028)


Figure 31             Total Cases of CRPS in the UK (2017-2028)


Figure 32             Gender specific Cases of Complex Regional Pain Syndrome in the UK (2017-2028)


Figure 33             Diagnosed Cases of CRPS in the UK (2017-2028)


Figure 34             Type Specific Diagnosed Cases of CRPS in the UK (2017-2028)


Figure 35             Number of CRPS cases in Associated Triggered Factors in the UK (2017-2028)


Figure 36             Total Cases of CRPS in Japan (2017-2028)


Figure 37             Gender specific Cases of Complex Regional Pain Syndrome in Japan (2017-2028)


Figure 38             Diagnosed Cases of CRPS in Japan (2017-2028)


Figure 39             Type Specific Diagnosed Cases of CRPS in Japan (2017-2028)


Figure 40             Number of CRPS cases in Associated Triggered Factors in Japan (2017-2028)


Figure 41             Pathophysiology and mechanism-based treatment options in CRPS


Figure 42             Four pillars of treatment for CRPS - an integrated interdisciplinary approach


Figure 43             CRPS rehabilitation algorithm for occupational therapists and physiotherapists


Figure 44             Management of CRPS in surgical outpatients


Figure 45             Unmet Needs of Complex Regional Pain Syndrome (CRPS)


Figure 46             Market Size of Complex Regional Pain Syndrome in 7MM in USD Million (2017-2028)


Figure 47             Market Size of Complex Regional Pain Syndrome in the US, USD Millions (2017-2028)


Figure 48             Market Size of CRPS by therapies in the US in USD Million (2017-2028)


Figure 49             Market Size of Complex Regional Pain Syndrome in Germany, USD Millions (2017-2028)


Figure 50             Market Size of CRPS by therapies in Germany in USD Million (2017-2028)


Figure 51             Market Size of Complex Regional Pain Syndrome in France, USD Millions (2017-2028)


Figure 52             Market Size of CRPS by therapies in France in USD Million (2017-2028)


Figure 53             Market Size of Complex Regional Pain Syndrome in Italy, USD Millions (2017-2028)


Figure 54             Market Size of CRPS by therapies in Italy in USD Million (2017-2028)


Figure 55             Market Size of Complex Regional Pain Syndrome in Spain, USD Millions (2017-2028)


Figure 56             Market Size of CRPS by therapies in Spain in USD Million (2017-2028)


Figure 57             Market Size of Complex Regional Pain Syndrome in the UK, USD Millions (2017-2028)


Figure 58             Market Size of CRPS by therapies in the UK in USD Million (2017-2028)


Figure 59             Market Size of Complex Regional Pain Syndrome in Japan, USD Millions (2017-2028)


Figure 60             Market Size of CRPS by therapies in Japan in USD Million (2017-2028)


Figure 61             Market Drivers


Figure 62             Market Barriers

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