Glioblastoma Multiforme Epidemiology

DelveInsight’s ‘Glioblastoma Multiforme Epidemiology Forecast–2034’ report delivers an in-depth understanding of the disease, historical and forecasted GBM epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

Geography Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Glioblastoma Multiforme (GBM) Understanding

Glioblastoma (GBM) is the most frequently occurring type of primary tumors of the central nervous system (CNS) mostly in adults, and its poor prognosis has not been significantly improved despite the fact that the innovative diagnostic strategies and new therapies have been developed. Somatic evolution promotes the progression of cancer in which the genome of the cancer cell is being deviated from that of the healthy cell due the accumulation of mutations. There is a remarkable development in GBM because it occurs via a complex network of various different molecular and genetic aberrations, which leads to significant changes in major signaling pathways. GBMs, as they extensively disperse throughout the parenchyma, making maximal surgical resection unattainable and having high level of vascularization, are lethal in nature.

GBM is often located in a region of the forebrain known as the cerebrum, which controls some of the most advanced process such as speech and emotions. While GBM is highly locally invasive (invading normal brain tissue), it rarely spreads to other organs beyond the brain. A highly aggressive, fast-growing cancer and treatment is often limited by the tumor location and the ability of a patient to tolerate surgery. Consequently, it is a particularly difficult cancer to treat.

Glioma is considered as the general term which is used to describe the primary brain tumors, and it is also classified to their presumed cell of origin accordingly. The classification includes astrocytic tumors (astrocytoma, anaplastic astrocytoma and glioblastoma), oligodendrogliomas, ependymomas, and mixed gliomas. Gliomas are classified into grade I TO IV on the basis of malignancy that is determined by the histopathalogical criteria. Although the location of GBM is commonly found in the supratentorial region (frontal, temporal, parietal, and occipital lobes), it is rarely located in the cerebellum part. Investigation of genetic and environmental factors of GBM have been done. Prior radiography, decreased susceptibility to allergy, immune factors and immune genes, as well as some nucleotide polymorphisms detected by genomic analysis are all included in the risk factors of the respective disease. The histological classification and tumor grading is a critical step for GBM diagnosis and prognosis.

GBM is a grade IV glioma according to the WHO 2007 classification and is the most common and lethal primary malignancy of the central nervous system. Despite multidisciplinary treatments such as surgery, chemotherapy, and radiotherapy, the median survival time for patients with GBM is only 14.6 months. Due to its high degree of invasiveness, radical tumor resection is not curative. From various experimental evidences it is explained that GBM contains a subpopulation of highly tumorigenic cells (GBM stem cells) from which recurrent GBM is thought to derive, and that GBM has the capacity to differentiate into multiple lineages of tumor genesis.

GBMs can be classified into primary and secondary GBMs:

• Primary GBM occurs de novo without evidence of a less malignant precursor
• Secondary GBM develops from initially low-grade diffuse astrocytoma (WHO grade II diffuse astrocytoma) or anaplastic astrocytoma (Grade III).

Glioblastoma Multiforme Epidemiology Perspective by DelveInsight

The GBM epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Incident Population of Glioblastoma Multiforme (GBM), Gender-specific Diagnosed Incidence of Glioblastoma Multiforme (GBM), Type-specific Diagnosed Incidence of Glioblastoma Multiforme (GBM), Age-specific Diagnosed Incidence of Glioblastoma Multiforme (GBM), Diagnosed Incident Population According To Primary Site Of Glioblastoma Multiforme (GBM) Tumour and Diagnosed Incident Population According To Histologic Classification of Glioblastoma Multiforme (GBM) in the 7MM market covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2021 to 2034.

Glioblastoma Multiforme (GBM) Detailed Epidemiology Segmentation

• The total diagnosed incident population of GBM in the 7 major markets was estimated to be 29,440 in 2020. In case of GBM patients in the United States, the diagnosed incident cases were 15,426 in 2020.
• The total diagnosed incident cases of GBM patients were maximum in males as compared to females in the 7 MM during the study period of 2021-2034.
• In the EU5 countries, the diagnosed incident population of GBM was maximum in Germany with 2,945 cases followed by France with 2,772 cases in 2020. While, Spain accounted for the lowest diagnosed incident population of 1,462 in 2020.
• As per Delvelnsight’s analysis, Japan had 1,950 diagnosed incident cases of GBM in 2020.
• There were 13,884 patients affected with primary GBM and 1,543 with secondary GBM in 2020, in the United States.
• The maximum number of the diagnosed incident population in the United States, in 2020, was found at the parietal site with 6,201 cases, followed by frontal tumors with 4,505 cases, temporal tumors with 2,391 cases, 1,620 cases of occipital tumors, and 710 cases of unknown and other tumors.
• In 2020, the maximum number of the diagnosed incident population according to the histological classification of GBM were conventional GBM type with 14,964 cases while the lowest incident cases were of GC-GBM type with 123 cases, in the United States.
• In the United States, the maximum number of GBM patients lie in the age group of 35–64, which accounted for 10,768 cases in 2020. In contrast, the least number of patients lie in the age group of <18, which was 617 in 2020.

Scope of the Report

• The report covers the descriptive overview of Glioblastoma Multiforme (GBM), explaining its causes, signs and symptoms, pathophysiology.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan.
• The report assesses the disease risk and burden and highlights the unmet needs of Glioblastoma Multiforme (GBM).
• The report provides the segmentation of the Glioblastoma Multiforme epidemiology for the 7MM by Total Diagnosed Incident Population of Glioblastoma Multiforme (GBM), Gender-specific Diagnosed Incident Population of Glioblastoma Multiforme (GBM), Age-specific Diagnosed Incident Population of Glioblastoma Multiforme (GBM), Type-specific Diagnosed Incident Population of Glioblastoma Multiforme (GBM), etc.

Report Highlights

• Ten Year Forecast of Glioblastoma Multiforme (GBM)
• 7MM Coverage
• Total Diagnosed Incident Population of Glioblastoma Multiforme (GBM)
• Delvelnsight has analysed type-specific data of GBM according to which there are two main types of Glioblasoma: Primary (de novo) and Secondary Glioblastoma, where the majority of cases (>90%) are primary glioblastomas that develop rapidly de novo, without clinical or histological evidence of a less malignant precursor lesion.
• Diagnosed incidence according to histological classification of Glioblastoma Multiforme tumor was also assessed, which suggests that the conventional GBM type is more prevalent than giant cell GBM (GC-GBM), and gliosarcoma (GS).
• In addition, gener-specific incidence of Glioblastoma Multiforme was also assessed. As per the analysis, GBM is more prevalent in males than in females.
• The epidemiology segmentation also encompasses diagnosed incident population according to primary site of glioblastoma. As per the DelveInsight estimates, it has been found that the primary site of GBM included maximum cases at parietal site, while minimum number of cases were found in unknown and other sites. This trend is clearly evident across all the 7MM countries for the study period 2021-2034.
• The report also encompasses another major segment, i.e., Age-specific Diagnosed Incident Population of Glioblstoma Multiforme (GBM), wherein various age groups have been considered, such as <18, 18–34, 35–64, 65–74 and 75+. It has been found that GBM incidence increases with age peaking at 75–84 years and drops after 85 years.

Key Questions Answered

• What is the disease risk, burden and unmet needs of Glioblastoma Multiforme (GBM)?
• What is the historical Glioblastoma Multiforme (GBM) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
• What would be the forecasted patient pool of Glioblastoma Multiforme (GBM) at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Glioblastoma Multiforme (GBM)?
• Out of the above-mentioned countries, which country would have the highest incident population of Glioblastoma Multiforme (GBM) during the forecast period (2025-2034)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2025-2034)?

Reasons to buy

The Glioblastoma Multiforme (GBM) report will allow the user to -

• Develop business strategies by understanding the trends shaping and driving the 7MM Glioblastoma Multiforme (GBM) market.
• Quantify patient share distribution in the 7MM for Glioblastoma Multiforme (GBM).
• The GBM epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The Glioblastoma Multiforme epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the eleven-year forecast period using reputable sources.

Key Assessments

• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population