helicobacter pylori h pylori infection epidemiology forecast

Key Highlights

• According to DelveInsight’s analysis, total diagnosed prevalent cases of H. pylori infection were around 57 million in the United States in 2025.
• H. pylori infection burden is decreasing overall due to improved hygiene, sanitation, living conditions, and widespread antibiotic use, which have reduced transmission, especially in younger generations. However, prevalence remains high in Spain in both children and adults because of persistent intrafamilial transmission, historical high infection rates in older cohorts, and regional socioeconomic and household crowding factors that continue to support early-life exposure and ongoing spread.
• H. pylori is the strongest identified risk factor for gastric malignancies, with recent data indicating that approximately 76% of all gastric cancers worldwide are attributable to the infection. While H. pylori infects more than half of the global population, clinical outcomes exhibit significant heterogeneity; it is estimated that roughly 20% of infected individuals eventually develop associated pathologies, ranging from dyspepsia and peptic ulcer disease to gastric adenocarcinoma and MALT lymphoma.
• In the US, age-specific trends in H. pylori infection show a clear correlation with increasing age, with prevalence generally rising among older adults. The infection is often acquired in childhood, and prevalence increases across adult age groups, reflects historical exposure and slower decline in older cohorts.
• In EU4 and the UK, in 2025, among gender-specific diagnosed prevalent H. pylori cases to be higher in females than in males.

Helicobacter pylori (H. pylori) Infection Epidemiology forecast

• 2025 Prevalent Cases of H. pylori Infection: ~148 million
• 2036 Prevalent Cases of H. pylori Infection: ~154 million
• H. pylori Infection Growth Rate (2026–2036): 0.36% CAGR

DelveInsight's ‘Helicobacter pylori (H. pylori) Infection –Epidemiology Forecast – 2036’ report delivers an in-depth understanding of the H. pylori infection, historical and forecasted epidemiology, in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom.

Helicobacter pylori (H. pylori) Infection Understanding and Diagnosis Algorithm

Helicobacter pylori (H. pylori) Infection Overview and Diagnosis

Helicobacter pylori (H. pylori) is a spiral-shaped, flagellated, gram-negative, microaerophilic bacterium that infects the stomach lining. The infection is usually acquired in childhood and can persist for years if untreated, often leading to chronic gastritis and peptic ulcer disease, and increasing the risk of gastric cancer and MALT lymphoma.

The diagnosis of active H. pylori infection requires detection of the bacterium and its activity, using noninvasive or invasive methods. Non-invasive tests, primarily the UBT and SAT, are highly sensitive and specific, whereas serologic IgG testing cannot reliably distinguish active from past infection. Invasive approaches, including upper endoscopy with biopsy, provide confirmatory evidence through histology, RUT, culture, or PCR; culture offers definitive specificity and enables antibiotic susceptibility testing, but is technically demanding and less sensitive. Standard clinical practice confirms infection using either two positive noninvasive tests or at least two positive invasive tests (e.g., histology plus urease).

Further details are provided in the report….

Helicobacter pylori (H. pylori) Infection Epidemiology

Key Findings from H. pylori Infection Epidemiological Analysis and Forecast

• According to DelveInsight’s estimates, the total diagnosed prevalent cases of H. pylori infection in the 6MM were approximately ~148 million in 2025.
• In 2025, Spain accounted the highest number of diagnosed prevalent cases of H. pylori infection while the UK accounted for the least number of cases of the total diagnosed prevalent population in EU4 and the UK, adults represent approximately 22% of cases in Germany, 19% in France, 18% in Italy, 23% in Spain, and 17% in the UK, whereas children account for a smaller proportion, ranging from 6% in Germany to 11% in the UK across these countries.

Scope of the Report

• The report covers a segment of a descriptive overview of H. pylori Infection, explaining their causes, signs and symptoms, and pathogenesis.
• Comprehensive insight has been provided into the epidemiology forecasts, the future growth potential of the diagnosis rate, and disease progression.

Report Insights

• H. pylori Infection Patient population forecast

Report Key Strengths

• Epidemiology-based (Epi-based) bottom-up Forecasting
• 11-year Forecast
• Patient Burden trends (by geography)

FAQs

• What are the disease risks, burdens, and unmet needs of H. pylori Infection? What will be the growth opportunities across the 7MM concerning the patient population with H. pylori Infection?
• What is the historical and forecasted H. pylori Infection patient pool in the US, EU4 (Germany, France, Italy, and Spain), the UK, and Japan?

Reasons to Buy

• Insights on patient burden/disease prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand key opinion leaders’ perspectives around the diagnostic challenges to overcome barriers in the future.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.