Hepatic Encephalopathy Market

DelveInsight’s ‘Hepatic Encephalopathy (HE)-Market Insights, Epidemiology, and Market Forecast–2030’ report deliver an in-depth understanding of the Hepatic Encephalopathy (HE), historical and forecasted epidemiology as well as the Hepatic Encephalopathy (HE) market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

 

The HE market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM HE market size from 2018 to 2030. The Report also covers current HE treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2018–2030

Hepatic Encephalopathy (HE) Disease Understanding and Treatment Algorithm

Hepatic Encephalopathy (HE) Overview

Hepatic encephalopathy (HE) is a brain disorder that develops in some individuals with liver disease. HE presents as a spectrum of neuropsychiatric symptoms ranging from subtle fluctuating cognitive impairment to coma and is a significant contributor to morbidity in patients with liver disease. It is observed in acute liver failure, liver bypass procedures – for example, shunt surgery and trans-jugular intrahepatic portosystemic shunt – and cirrhosis, classified as Type A, B, and C HE, respectively. Pathogenesis is linked with ammonia and glutamine production. Treatment is based on mechanisms to reduce these compounds’ formation and/or removal; many of the symptoms are reversible when promptly detected and treated.

 

Moreover, HE can be associated with more severe symptoms, including reduced alertness, shortened attention span, disruptions in sleep patterns, mild confusion, slowing ability to perform mental tasks, and mood or personality changes. More noticeable changes in memory, concentration, or intellectual function than in minimal hepatic encephalopathy (MHE) may also be observed. HE can also be classified according to whether its presence is overt or covert. When affected individuals have obvious, outward signs and symptoms, the disorder may be referred to as overt hepatic encephalopathy (OHE).

 

Hepatic Encephalopathy (HE) Diagnosis

Defining and diagnosing HE, particularly covert HE (CHE), remain challenging. In CHE, there are no clinical signs or symptoms; however, patients have neuropsychological deficiencies that can be detected with psychometric or neuropsychological testing.

 

The HE diagnosis is based on the presence of a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction after excluding unrelated neurologic and/or metabolic causes of encephalopathy.

Continued in the report…..

 

Hepatic Encephalopathy (HE) Treatment

The treatment of acute or persistent HE has changed very little during the past 40 years. However, with newer agents under investigation, the available treatment options will increase over 5 years. Until then, treatment options are limited to correcting or removing precipitating causes, dietary changes, and pharmacologic approaches that are focused on the use of non-absorbable disaccharides. Additional pharmacological agents available include certain antibiotics, drugs to eliminate ammonia from the plasma, and a few other drugs with special indications.

 

Management of OHE includes treating patients with acute HE episodes, preventing HE recurrence, and identifying and managing precipitating factors associated with HE development. The two primary forms of medical therapy for HE are non-absorbable disaccharides (i.e., lactitol and lactulose) and non-absorbable antibiotics (i.e., Rifaximin). The hyperammonemia and inflammation that occurs due to urea breakdown in cirrhotic have led to the development of HE treatments that target gut bacteria. Treatments for OHE are approved by the US FDA and some unapproved treatments are available for use. It is important to remember that in patients with cirrhosis and portosystemic shunting, skeletal muscle mass and renal clearance are vital to neurotoxin clearance.

Hepatic Encephalopathy (HE) Epidemiology             

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by total diagnosed prevalent cases of hepatic encephalopathy, gender-specific diagnosed prevalent cases of hepatic encephalopathy, age-specific diagnosed prevalent cases of hepatic encephalopathy and type-specific diagnosed prevalent cases of hepatic encephalopathy scenario of Hepatic Encephalopathy (HE) in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2018 to 2030.

 

Key Findings

  • Total diagnosed prevalent cases of Cirrhosis (hospitalized) in the 7MM was found to be 860,784 in 2020. These cases are expected to increase by 2030 at a CAGR of 0.63% during study period (2018–2030).
  • The diagnosed prevalent cases of Hepatic Encephalopathy in the 7MM is expected to increase at a CAGR of 0.61% for the study period of 2018-2030.
  • Among 7MM, the United States has the highest diagnosed prevalent cases of hepatic encephalopathy with 205,018 cases in 2020.
  • Assessments as per DelveInsight’s analysts show that the majority of cases of Hepatic Encephalopathy are occupied by males as compared to females. There was a total of 149,048 male and 55,970 female cases of Hepatic Encephalopathy in 2020 in the United States.
  • The age‐specific data revealed that the highest number of Hepatic Encephalopathy people affected with was found in the age group of 45–54 years, while people <25 years, are the least affected.
  • HE is divided into two broad categories based on severity, Covert Hepatic Encephalopathy (CHE) and Overt Hepatic Encephalopathy (OHE). There were total 123,011 CHE and 82,007 OHE cases of Hepatic Encephalopathy in 2020 in the United States.
  • In EU-5, the United Kingdom has the highest number of cases of HE with 27,556 cases in 2020, followed by Germany with 26,672 cases and France with 22,276 cases. While Spain has the least number of cases with 9,808 in 2020.
  • In 2020, Japan had 29,571 diagnosed prevalent cases of HE. These cases are expected to increase by 2030 at a CAGR of 0.20%.

Country-WIse Hepatic Encephalopathy (HE) Epidemiology

The epidemiology segment also provides the Hepatic Encephalopathy (HE) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Hepatic Encephalopathy (HE) Drug Chapters

The drug chapter segment of the Hepatic Encephalopathy (HE) report encloses the detailed analysis of Hepatic Encephalopathy (HE) marketed drugs, mid-phase, and late-stage pipeline drugs. It also helps to understand the Hepatic Encephalopathy (HE) clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details of each included drug and the latest news and press releases.

 

Hepatic Encephalopathy (HE) Marketed Drugs

 

Xifaxan (Rifaximin/OHE7): Salix Pharmaceuticals/Bausch Health

Xifaxan (Rifaximin) tablets (550 mg) developed and marketed by Salix Pharmaceuticals (a subsidiary of Valeant Pharmaceuticals), was indicated for the reduction in risk of Overt Hepatic Encephalopathy (HE) recurrence in patients ≥ 18 years of age. It is also being marketed to treat Travelers’ Diarrhea and IBS-D (Irritable Bowel Syndrome with Diarrhea). Salix is exploring the potential additional indications, formulations, and clinical trials, and co-promotion arrangements for Xifaxan to capitalize the potential for Xifaxan, including development programs in Crohn’s disease and liver disease.

Products detail in the report…

 

Hepatic Encephalopathy (HE) Emerging Drugs

 

AXA1665: Axcella Health, Inc.

AXA1665—Axcella’s product candidate for a reduction in risk of recurrent overt hepatic encephalopathy (OHE)—is a composition of eight amino acids and derivatives designed to target multiple metabolic pathways intersecting key organ systems, including the liver, muscle, and gut. The company is currently evaluating AXA1665 in the Phase II stage of clinical development as a product candidate to reduce the risk of OHE recurrence in adult patients with liver cirrhosis

Products detail in the report…

 

GR3027 (Golexanolone): Umecrine Cognition

Umecrine Cognition, a Karolinska Development (KDEV), is developing novel GR3027 (golexanolone), an orally administrated small molecule to treat patients diagnosed with HE. Golexanolone is a GABAA-receptor modulating steroid antagonist (GAMSA) designed to antagonize positive GABAA-receptor modulation by endogenous neuroactive steroids. Golexanolone belongs to a novel class of neurosteroid-based drugs for oral administration. According to the company pipeline, although the drug is being investigated for HE, the trial is being conducted for covert hepatic encephalopathy (CHE) in a Phase I/IIa trial

Products detail in the report…

List to be continued in the report…

Hepatic Encephalopathy (HE) Market Outlook

The United States contributes to the major share of the Hepatic Encephalopathy (HE) market as compared to other countries, such as EU5 (Italy, Spain, United Kingdom, France, and Germany) and Japan.

 

Management of OHE includes treating patients with acute HE episodes, preventing HE recurrence, and identifying and managing precipitating factors associated with HE development. The two primary forms of medical therapy for HE are non-absorbable disaccharides (i.e., lactitol and lactulose) and non-absorbable antibiotics (i.e., Rifaximin). The hyperammonemia and inflammation that occurs due to urea breakdown in cirrhotics have led to the development of HE treatments that target gut bacteria. Treatments for OHE are approved by the US FDA and some unapproved treatments are available for use. It is important to remember that in patients with cirrhosis and portosystemic shunting, skeletal muscle mass and renal clearance are vital to neurotoxin clearance.

 

Treatment options for CHE are derived from prior experience in patients with episodic HE. Given the lack of clinical signs, CHE is rarely recognized or treated outside of clinical trials. The treatment of CHE is on an as-needed basis. First-line treatment is a 4- to 8-week trial of lactulose. If the patient improves, treatment can continue. Due to the high cost of Rifaximin is usually not used for CHE.

 

According to DelveInsight, Hepatic Encephalopathy (HE) 7MM is expected to change in the study period 2018–2030.

 

Key Findings

  • The market size of Hepatic Encephalopathy (HE) in seven major markets was USD 1,448 million in 2020, which is further expected to increase by 2030 at a Compound Annual Growth Rate (CAGR) of 5.31% for the study period (2018–2030)
  • Expected Launch of potential therapies may increase market size in the coming years, assisted by an increase in diagnosed prevalent population of Hepatic Encephalopathy.
  • Upcoming therapies such Golexanolone (GR3027) and Rifaximin (SSD) have the potential to create a significant positive shift in the Hepatic Encephalopathy market size.
  • The United States accounts for the largest market size of Hepatic Encephalopathy, in comparison to EU5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan.
  • Among the EU5 countries, Germany had the highest market size with USD 45 million in 2020, while Spain had the lowest market size of Hepatic Encephalopathy with USD 16 million in 2020.

 

The United States Market Outlook

This section provides the total Hepatic Encephalopathy (HE) market size and; market size by therapies in the United States.

 

EU-5 Market Outlook

The total Hepatic Encephalopathy (HE) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

 

Japan Market Outlook

The total Hepatic Encephalopathy (HE) market size and market size by therapies in Japan are provided.

Hepatic Encephalopathy (HE) Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the Hepatic Encephalopathy (HE) market or expected to get launched in the market during the study period 2018–2030. The analysis covers Hepatic Encephalopathy (HE) market uptake by drugs; patient uptake by therapies; and sales of each drug.

 

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Hepatic Encephalopathy (HE) Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition, and merger, licensing, and patent details for Hepatic Encephalopathy (HE) emerging therapies.

Reimbursement Scenario in Hepatic Encephalopathy (HE)

Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

Competitive Intelligence Analysis

We perform competitive and market Intelligence analysis of the Hepatic Encephalopathy (HE) market by using various competitive intelligence tools that include–SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

  • The report covers the descriptive overview of Hepatic Encephalopathy (HE), explaining its etiology, signs and symptoms, pathophysiology, genetic basis, and currently available therapies.
  • Comprehensive insight has been provided into the Hepatic Encephalopathy (HE) epidemiology and treatment.
  • Additionally, an all-inclusive account of both the current and emerging therapies for Hepatic Encephalopathy (HE) is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
  • A detailed review of the Hepatic Encephalopathy (HE) market; historical and forecasted is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Hepatic Encephalopathy (HE) market.

Report Highlights

  • The robust pipeline with novel MOA and oral ROA and increasing prevalence will positively drive the Hepatic Encephalopathy (HE) market.
  • The companies and academics are working to assess challenges and seek opportunities that could influence Hepatic Encephalopathy (HE) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
  • Major players are involved in developing therapies for Hepatic Encephalopathy (HE). Launch of emerging therapies will significantly impact the Hepatic Encephalopathy (HE) market.
  • Our in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Hepatic Encephalopathy (HE) Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Hepatic Encephalopathy (HE) Pipeline Analysis
  • Hepatic Encephalopathy (HE) Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies

Hepatic Encephalopathy (HE) Report Key Strengths

  • 10-Years Forecast
  • 7MM Coverage
  • Hepatic Encephalopathy (HE) Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Hepatic Encephalopathy (HE) Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers
  • SWOT analysis

Key Questions

Market Insights:

  • What was the Hepatic Encephalopathy (HE) market share (%) distribution in 2018 and how it would look like in 2030?
  • What would be the Hepatic Encephalopathy (HE) total market size as well as market size by therapies across the 7MM during the forecast period (2021–2030)?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest Hepatic Encephalopathy (HE) market size during the forecast period (2021–2030)?
  • At what CAGR, the Hepatic Encephalopathy (HE) market is expected to grow at the 7MM level during the forecast period (2021–2030)?
  • What would be the Hepatic Encephalopathy (HE) market outlook across the 7MM during the forecast period (2021–2030)?
  • What would be the Hepatic Encephalopathy (HE) market growth till 2030 and what will be the resultant market size in the year 2030?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

 

Epidemiology Insights:

  • What is the disease risk, burden and unmet needs of Hepatic Encephalopathy (HE)?
  • What is the historical Hepatic Encephalopathy (HE) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
  • What would be the forecasted patient pool of Hepatic Encephalopathy (HE) at the 7MM level?
  • What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Hepatic Encephalopathy (HE)?
  • Out of the above-mentioned countries, which country would have the highest prevalence population of Hepatic Encephalopathy (HE) during the forecast period (2021–2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2021–2030)?

 

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies:

  • What are the current options for the treatment of Hepatic Encephalopathy (HE) along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Hepatic Encephalopathy (HE) in the US and Europe?
  • What are the Hepatic Encephalopathy (HE) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Hepatic Encephalopathy (HE)?
  • How many emerging therapies are in the mid-stage and late stages of development for the treatment of Hepatic Encephalopathy (HE)?
  • What are the key collaborations (Industry–Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Hepatic Encephalopathy (HE) therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Hepatic Encephalopathy (HE) and their status?
  • What are the key designations that have been granted for the emerging therapies for Hepatic Encephalopathy (HE)?
  • What are the 7MM historical and forecasted market of Hepatic Encephalopathy (HE)?

Reasons to buy

  • The report will help in developing business strategies by understanding trends shaping and driving the Hepatic Encephalopathy (HE).
  • To understand the future market competition in the Hepatic Encephalopathy (HE) market and Insightful review of the key market drivers and barriers.
  • Organize sales and marketing efforts by identifying the best opportunities for Hepatic Encephalopathy (HE) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
  • Organize sales and marketing efforts by identifying the best opportunities for the Hepatic Encephalopathy (HE) market.
  • To understand the future market competition in the Hepatic Encephalopathy (HE) market.

1. Key Insights

2. Report Introduction

3. Hepatic Encephalopathy (HE) Market Overview at a Glance

3.1. Market Share (%) Distribution of HE by therapies in 2018

3.2. Market Share (%) Distribution of HE by therapies in 2030

4. Hepatic Encephalopathy Market: Future Perspective

5. Executive Summary of Hepatic Encephalopathy (HE)

6. Key Events

7. Disease Background and Overview

7.1. Introduction

7.2. Classification of Hepatic Encephalopathy (HE)

7.3. Symptoms

7.4. Cause and Risk Factors

7.5. Pathophysiology

7.6. Pathogenesis

7.7. Diagnosis

7.7.1. Differential Diagnosis for HE

7.7.2. Diagnostic Algorithm

7.7.3. Diagnostic Guidelines

7.7.3.1. Hepatic Encephalopathy in Chronic Liver Disease 2014 Practice Guideline by AASLD and EASL

7.7.3.2. Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)

7.8. Treatment and Management

7.8.1. Line of therapies for the treatment of Hepatic Encephalopathy

7.8.2. Treatment Algorithm

7.8.3. Treatment Guidelines

7.8.3.1. Practice Guideline on Hepatic Encephalopathy from the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver

7.8.3.2. Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)

8. Epidemiology and Patient Population

8.1. Key Findings

8.2. Methodology of Epidemiology

8.3. Assumptions and Rationale: 7MM

8.4. Total Diagnosed Prevalent Cases of Cirrhosis (Hospitalization Cases of Cirrhosis) in the 7MM

8.5. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy (HE) in the 7MM

8.6. The United States

8.6.1. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States

8.6.2. Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States

8.6.3. Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States

8.6.4. Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States

8.7. EU-5

8.7.1. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5

8.7.2. Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5

8.7.3. Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5

8.7.4. Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5

8.8. Japan

8.8.1. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan

8.8.2. Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan

8.8.3. Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan

8.8.4. Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan

9. Patient Journey

10. Marketed Therapies

10.1. Xifaxan (Rifaximin/OHE7): Salix Pharmaceuticals/Bausch Health

10.1.1. Product Description

10.1.2. Regulatory Milestones

10.1.3. Research and Development

10.1.4. Clinical Trials Information

10.1.5. Safety and Efficacy

10.1.6. Product Profile

11. Emerging Drugs

11.1. Key Cross Competition

11.2. AXA1665: Axcella Health, Inc.

11.2.1. Product Description

11.2.2. Other Developmental Activities

11.2.3. Clinical Development

11.2.4. Clinical Trials Information

11.2.5. Safety and Efficacy

11.2.6. Product Profile

11.2.7. Analysts’ Views

11.3. GR3027 (Golexanolone): Umecrine Cognition

11.3.1. Product Description

11.3.2. Other Developmental Activities

11.3.3. Clinical Development

11.3.4. Safety and Efficacy

11.3.5. Product Profile

11.3.6. Analysts’ Views

11.4. MNK-6105/MNK-6106 (OCR-002): Mallinckrodt Therapeutics

11.4.1. Product Description

11.4.2. Other Developmental Activities

11.4.3. Clinical Development

11.4.4. Clinical Trials Information

11.4.5. Safety and Efficacy

11.4.6. Product Profile

11.4.7. Analysts’ Views

11.5. VE303: Vedanta Biosciences/Patricia Bloom

11.5.1. Product Description

11.5.2. Clinical Development

11.5.3. Clinical Trials Information

11.5.4. Product Profile

12. Hepatic Encephalopathy (HE): Seven Major Market Analysis

12.1. Key Findings

12.2. Methodology of Hepatic Encephalopathy (HE) Market

12.3. Market Size of Hepatic Encephalopathy in the 7MM

12.4. Market Size of Hepatic Encephalopathy by Therapies in the 7MM

12.5. Emerging Drug Analysis

12.6. Key Market Forecast Assumptions

12.7. Attribute Analysis

12.8. Market Outlook

12.9. Market Size of Hepatic Encephalopathy in the United States

12.9.1. Total Market Size of Hepatic Encephalopathy

12.9.2. Market Size of Hepatic Encephalopathy by Therapies

12.10. Market Size of Hepatic Encephalopathy in EU-5

12.10.1. Total Market Size of Hepatic Encephalopathy

12.10.2. Market Size of Hepatic Encephalopathy by Therapies

12.11. Market Size of Hepatic Encephalopathy in Japan

12.11.1. Total Market Size of Hepatic Encephalopathy

12.11.2. Market Size of Hepatic Encephalopathy by Therapies

13. KOL Views

14. Market Drivers

15. Market Barriers

16. SWOT Analysis

17. Unmet Needs

18. Reimbursement and Market Access

18.1. United States

18.2. Europe

19. Appendix

19.1. Bibliography

19.2. Report Methodology

20. DelveInsight Capabilities

21. Disclaimer

22. About DelveInsight

List of Table

Table 1: Summary of HE Market and Epidemiology (2018–2030)

Table 2: Key Events

Table 3: Clinical Description of Hepatic Encephalopathy (Adapted from AASLD-EASL Guideline, 2014)

Table 4: West Haven Criteria for HE and symptoms

Table 5: The Five Clinical Patterns of HE Presentation

Table 6: Stages of HE

Table 7: Differential Diagnosis

Table 8: Common Treatment Options for Hepatic Encephalopathy

Table 9: Precipitating Factors of OHE

Table 10: Concomitant medical conditions that can affect patients with overt hepatic encephalopathy

Table 11: Treatment Summary

Table 12: Practice Guideline on Hepatic Encephalopathy from the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver

Table 13: Total Diagnosed Prevalent Cases of Cirrhosis (Hospitalization Cases of Cirrhosis) in the 7MM (2018–2030)

Table 14: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy (HE) in the 7MM (2018–2030)

Table 15: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Table 16: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Table 17: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States (2018–2030)

Table 18: Type-Specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Table 19: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy Cases in EU-5 (2018–2030)

Table 20: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5 (2018–2030)

Table 21: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU5 (2018–2030)

Table 22: Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU5 (2018–2030)

Table 23: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Table 24: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the Japan (2018–2030)

Table 25: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Table 26: Type-Specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Table 27: Rifaximin, Clinical Trial Description, 2021

Table 28: Comparison of emerging drugs under development

Table 29: AXA1665, Clinical Trial Description, 2021

Table 30: OCR-002 (MNK-6105/ MNK-6106), Clinical Trial Description, 2021

Table 31: VE303, Clinical Trial Description, 2021

Table 32: Market Size of Hepatic Encephalopathy in the 7MM in USD Million (2018–2030)

Table 33: Market Size of Hepatic Encephalopathy by Therapies in the 7MM in USD Million (2018–2030)

Table 34: Key Market Forecast Assumptions for GR3027 (Golexanolone)

Table 35: Key Market Forecast Assumptions for Rifaximin (SSD)

Table 36: United States Market Size of Hepatic Encephalopathy in USD Million (2018–2030)

Table 37: Market Size of Hepatic Encephalopathy by Therapies in the US in USD Million (2018–2030)

Table 38: EU-5 Market Size of Hepatic Encephalopathy in USD Million (2018–2030)

Table 39: Market Size of Hepatic Encephalopathy by Therapies in EU5, in USD Million (2018–2030)

Table 40: Market Size of Hepatic Encephalopathy in Japan, in USD Million (2018–2030)

Table 41: Market Size of Hepatic Encephalopathy by Therapies in Japan in USD Million (2018–2030)

List of Figures

Figure 1: Symptoms of HE

Figure 2: Grading of the symptoms of HE

Figure 3: Risk Factors of HE

Figure 4: Pathophysiology of HE

Figure 5: Ammonia Trafficking in HE from an Organism (left panel) and an Organ (right panel) Perspective

Figure 6: Diagnostic tree for HE, ammonia reducing treatments

Figure 7: The Classification of HE

Figure 8: Management of patients with hepatic encephalopathy (HE)

Figure 9: Treatment algorithm for patients with Overt Hepatic Encephalopathy (OHE)

Figure 10: Total Diagnosed Prevalent Cases of Cirrhosis (Hospitalization Cases of Cirrhosis) in the 7MM (2018–2030)

Figure 11: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy (HE) in the 7MM (2018–2030)

Figure 12: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Figure 13: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Figure 14: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Figure 15: Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in the US (2018–2030)

Figure 16: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy Cases in EU-5 (2018–2030)

Figure 17: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5 (2018–2030)

Figure 18: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5 (2018-2030)

Figure 19: Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in EU-5 (2018-2030)

Figure 20: Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Figure 21: Gender-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Figure 22: Age-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Figure 23: Type-specific Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2018–2030)

Figure 24: Patient Journey

Figure 25: Market Size of Hepatic Encephalopathy in the 7MM in USD Million (2018–2030)

Figure 26: Market Size of Hepatic Encephalopathy by Therapies in the 7MM in USD Million (2018–2030)

Figure 27: Market Size of Hepatic Encephalopathy in the United States, USD Millions (2018–2030)

Figure 28: Market Size of Hepatic Encephalopathy by Therapies in the United States, in USD Million (2018–2030)

Figure 29: Market Size of Hepatic Encephalopathy in EU5, USD Millions (2018–2030)

Figure 30: Market Size of Hepatic Encephalopathy by Therapies, in EU5, in USD Million (2018–2030)

Figure 31: Market Size of Hepatic Encephalopathy in Japan, USD Millions (2018–2030)

Figure 32: Market Size of Hepatic Encephalopathy by Therapies in Japan, in USD Million (2018–2030)

Figure 33: Market Drivers

Figure 34: Market Barriers

Figure 35: SWOT Analysis

Figure 36: Unmet Needs

Salix Pharmaceuticals
Bausch Health
Axcella Health, Inc.
Umecrine Cognition
Mallinckrodt Therapeutics
Vedanta Biosciences
Patricia Bloom

 

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