Hpv16+ Anogenital Cancers Market

Key Highlights

• According to HPV Information Center, (2021), age-standardized incidence rate of Anal cancer was 0.31 and 0.26 in men and women respectively,  0.47 for Vulva cancer, 0.20 for Vaginal Cancer, and 0.25 for Penile Cancer in Japan.

• HPV16+ Anogenital Cancers epidemiology is segmented as Incident Cases of HPV 16+ Anogenital Cancer and Treated Cases of HPV 16+ Anogenital Cancer] in the HPV16+ Anogenital Cancers market report.

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DelveInsight's "HPV16+ Anogenital Cancers Market Insights, Epidemiology, and Market Forecast — 2032" report delivers an in-depth understanding of the HPV16+ Anogenital Cancers, historical and forecasted epidemiology as well as the HPV16+ Anogenital Cancers market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The HPV16+ Anogenital Cancers market report provides current treatment practices, emerging drugs, HPV16+ Anogenital Cancers market share of the individual therapies, current and forecasted HPV16+ Anogenital Cancers market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current HPV16+ Anogenital Cancers treatment practice/algorithm, and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.

Geography Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2019–2032

HPV16+ Anogenital Cancers Market Disease: Understanding and Treatment Algorithm

The DelveInsight’s HPV16+ Anogenital Cancers market report gives a thorough understanding of HPV16+ Anogenital Cancers by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis, and treatment. Human papillomavirus (HPV) is the world’s most common sexually transmitted infection, with most people being infected at some point in their lifetime. Although for most people, it is symptomless, and they recover from the infection with no adverse effects, for a small proportion, the infection may lead to cancer. HPV-16 is a high-risk subtype associated with a variety of HPV-related cancers like cervical, head and neck, vulvar, oropharyngeal, penile, anal, and other cancers. HPV infects the squamous cells that line the inner surfaces of these organs.

Despite advances in understanding of the natural history of HPV infection and its role through persistence as the major risk factor in the development of cervical and other anogenital cancers. Primary (vaccination) or secondary prevention programs (cervical screening) can impact decisively in preventing cancer, but both these approaches are not available for many at greatest risk. The human papillomavirus infects by entering the body through a cut, scrape, or tear in one’s skin and can get it from skin-to-skin contact, or vaginal, anal, or oral sex. HPV can be passed to the baby if woman have genital warts while she is pregnant.

Symptoms of grade 1 and grade 2 HPV16+ Anogenital Cancers are subtle whereas, symptoms of grade 3 and grade 4 HPV16+ Anogenital Cancers may be sudden and debilitating. Symptoms can result from increased pressure within the brain and may include headaches, vision changes and nausea or vomiting.

HPV16+ Anogenital Cancers Diagnosis

Artificial Intelligence in cancer screening is being explored and will be a game-changer in the HPV16+ cancer market during the forecast period, 2022–2032. In addition, better strategies for maximizing vaccine uptake, the ongoing development of novel, more targeted intervention therapies, and promising candidate treatments will lead to better treatment outcomes in the future.

HPV16+ Anogenital Cancers Treatment

Over the last decade, HPV vaccination has been effective in the prevention of HPV-related diseases and has been recommended by the World Health Organization (WHO) as an effective primary prevention intervention against cancerous lesions. A widespread vaccination regime would help decrease the overall burden HPV infections inflict on public health systems.

HPV16+ Anogenital Cancers Epidemiology

The HPV16+ Anogenital Cancers epidemiology section provides insights about historical and current HPV16+ Anogenital Cancers patient pool and forecasted trends for individual seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

• According to HPV Information Center, (2021), age-standardized incidence rate of Anal cancer was 0.31 and 0.26 in men and women respectively,  0.47 for Vulva cancer, 0.20 for Vaginal Cancer, and 0.25 for Penile Cancer in Japan.

• The disease epidemiology covered in the report provides historical as well as forecasted HPV16+ Anogenital Cancers epidemiology [segmented as Incident Cases of HPV 16+ Anogenital Cancer and Treated Cases of HPV 16+ Anogenital Cancer] in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.

Country Wise- HPV16+ Anogenital Cancers Epidemiology

This section provides glimpse of the HPV16+ Anogenital Cancers epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

Learn more about the evolving epidemiology trends and key developments: HPV16-positive Anogenital Cancer Epidemiology Forecast
 

HPV16+ Anogenital Cancers Drug Chapters

The drug chapter segment of the HPV16+ Anogenital Cancers report encloses the detailed analysis of HPV16+ Anogenital Cancers marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the HPV16+ Anogenital Cancers clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

HPV16+ Anogenital Cancers Marketed Drugs

GARDASIL (HPV recombinant quadrivalent): Merck

It is approved by the FDA for all children and adults aged 9–26 and Cervarix for all children and adults aged 9–25. The FDA-approved indications for both vaccines to prevent cervical cancer and cervical dysplasia caused by HPV 16 and 18. Gardasil has the additional indications of preventing genital warts caused by HPV 6 and 11 and anal cancer and associated precancerous lesions of the anus caused by HPV 16 and 18.

Note: Detailed Current therapies assessment will be provided in the full report of HPV16+ Anogenital Cancers

HPV16+ Anogenital Cancers Emerging Drugs

VGX-3100, under development by Inovio Pharmaceuticals, is designed to utilize the patient’s immune system for clearing HPV-16/18 virus and HPV-16/18–associated high-grade precancerous lesions to reduce the risk of cancer.

ISA101b, being developed by ISA Pharmaceuticals, in collaboration with Regeneron, is a Synthetic Long Peptide (SLP) therapeutic designed to mount a highly specific, broad, and durable, T-cell–mediated attack by the immune system on tumors positive for HPV16.

Note: Detailed emerging therapies assessment will be provided in the full report of HPV16+ Anogenital Cancers

HPV16+ Anogenital Cancers Market Outlook

HPVs are responsible for many penile, vulvar, and anal carcinomas cancer cases. Persistent infection with hrHPVs results in the development of squamous intraepithelial lesions (SILs): cervical intraepithelial neoplasia (CIN) and vulval intraepithelial neoplasia (VIN).

The treatment of most HPV infections involves agents that directly ablate the lesions (e.g., surgical excision, chemical ablation, and cryotherapy). Despite the progress in the HPV disease landscape, there is no FDA-approved therapy to date and patients rely on prophylactic treatment options. On the bright side, primary prevention of high-risk HPV-induced cancers is now possible via immunization with highly efficacious HPV vaccines.

Currently, there are three commercially available HPV vaccines: Cervarix, a bivalent HPV-16/18 vaccine; Gardasil, a quadrivalent HPV-6/11/16/18 vaccine; and Gardasil9, a nonavalent HPV-6/11/16/18/31/33/45/52/58 vaccine. The first vaccine to be approved, Gardasil, has been replaced by Gardasil 9 whose overall prevention of CIN 3 disease is noninferior to that of the competing cervical cancer HPV vaccine, Cervarix. Though these therapies have contributed significantly to lowering cancer rates around the globe, shortcomings like availability, access, prevention of recurrence, acceptability, and high costs make its overall uptake tedious, creating the demand for new therapeutic alternatives.

Key players such as PDS Biotechnology Corp./Merck, ISA Pharmaceuticals/Regeneron Pharmaceuticals, Vaccibody AS/Roche., Inovio Pharmaceuticals, Transgene, Advaxis and various others are involved in developing therapies for HPV16+ Anogenital Cancers.

According to DelveInsight, HPV16+ Anogenital Cancers market in 7MM is expected to witness a major change in the study period 2019-2032.

Analyst Commentary

• The pipeline of HPV16+ Anogenital Cancers is very robust, many potential therapies are being investigated for the treatment of HPV16+ Anogenital Cancers, and it is safe to predict that the treatment space will experience a significant impact on the market during the forecast period.

• The expected introduction of emerging therapies with improved efficacy, more awareness initiatives programs, and further improvement in the diagnosis rate, are likely to boost the growth of the HPV16+ Anogenital Cancers market in the 7MM. Aside from that, the market size of HPV16+ Anogenital Cancers may flourish due to increased research and development, label-expansion of approved therapies into other epilepsy in this field.

• The market growth of HPV16+ Anogenital Cancers may offset by failures and/or discontinuation of the emerging therapies, unaffordable pricing, market access and reimbursement issues, and a scarcity of healthcare specialists.

HPV16+ Anogenital Cancers Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the HPV16+ Anogenital Cancers market or expected to get launched in the market during the study period 2019-2032. The analysis covers HPV16+ Anogenital Cancers market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs, and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Note: Detailed emerging therapies assessment will be provided in full report of HPV16+ Anogenital Cancers.

HPV16+ Anogenital Cancers Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase II and Phase III stage. It also analyses HPV16+ Anogenital Cancers key players involved in developing targeted therapeutics.

HPV16+ Anogenital Cancers Clinical Trials Development Activities

The HPV16+ Anogenital Cancers clinical trials report covers the detailed information of collaborations, acquisition and merger, licensing, patent details and other information for HPV16+ Anogenital Cancers emerging therapies.

Reimbursement Scenario in HPV16+ Anogenital Cancers

Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In a report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

KOL- Views

To keep up with current market trends, we take KOLs and SMEs ' opinions working in the HPV16+ Anogenital Cancers domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or HPV16+ Anogenital Cancers market trends. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the HPV16+ Anogenital Cancers unmet needs.

Competitive Intelligence Analysis

We perform Competitive and Market Intelligence analysis of the HPV16+ Anogenital Cancers Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the HPV16+ Anogenital Cancers Market Report

• The report covers the descriptive overview of HPV16+ Anogenital Cancers, explaining its causes, signs and symptoms, pathophysiology, diagnosis, and currently available therapies
• Comprehensive insight has been provided into the HPV16+ Anogenital Cancers epidemiology and treatment in the 7MM
• Additionally, an all-inclusive account of both the current and emerging therapies for HPV16+ Anogenital Cancers are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
• A detailed review of the HPV16+ Anogenital Cancers market; historical and forecasted is included in the report, covering drug outreach in the 7MM
• Detailed Patient Based HPV16+ Anogenital Cancers Market Forecasting determines the trends shaping and driving the Global HPV16+ Anogenital Cancers market

HPV16+ Anogenital Cancers Market Report Highlights

• In the coming years, the HPV16+ Anogenital Cancers market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market
• The companies and academics are working to assess challenges and seek opportunities that could influence HPV16+ Anogenital Cancers R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition     
• Major players are involved in developing therapies for HPV16+ Anogenital Cancers. The launch of emerging therapies will significantly impact the HPV16+ Anogenital Cancers market
• A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for HPV16+ Anogenital Cancers
• Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends, and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities

HPV16+ Anogenital Cancers Report Insights

• Patient Based HPV16+ Anogenital Cancers Market Forecasting
• Therapeutic Approaches
• HPV16+ Anogenital Cancers Pipeline Analysis
• HPV16+ Anogenital Cancers Market Size and Trends
• Market Opportunities
• Impact of upcoming Therapies

HPV16+ Anogenital Cancers Report Key Strengths

• 11 Years Forecast
• 7MM Coverage
• HPV16+ Anogenital Cancers Epidemiology Segmentation
• Key Cross Competition
• Highly Analyzed Market
• Drugs Uptake

HPV16+ Anogenital Cancers Report Assessment

• Current Treatment Practices
• HPV16+ Anogenital Cancers Unmet Needs
• Pipeline Product Profiles
• Market Attractiveness

Key Questions

Market Insights:

• What was the HPV16+ Anogenital Cancers drug class share (%) distribution in 2019 and how it would look like in 2032?
• What would be the HPV16+ Anogenital Cancers total market size as well as market size by therapies across the 7MM during the forecast period (2019-2032)?
• What are the key findings of the market across 7MM and which country will have the largest HPV16+ Anogenital Cancers market size during the forecast period (2019-2032)?
• At what CAGR, the HPV16+ Anogenital Cancers market is expected to grow by 7MM during the forecast period (2019-2032)?
• What would be the HPV16+ Anogenital Cancers market outlook across the 7MM during the forecast period (2019-2032)?
• What would be the HPV16+ Anogenital Cancers market growth till 2032, and what will be the resultant market Size in the year 2032?
• How would the HPV16+ Anogenital Cancers unmet needs affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

• What are the disease risk, burden, and regional/ethnic differences of HPV16+ Anogenital Cancers?
• What are the key factors driving the epidemiology trend for seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
• What is the historical HPV16+ Anogenital Cancers patient pool in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
• What would be the forecasted patient pool of HPV16+ Anogenital Cancers in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
• Where will be the growth opportunities in the 7MM concerning the patient population about HPV16+ Anogenital Cancers?
• Out of all 7MM countries, which country would have the highest incident population of HPV16+ Anogenital Cancers during the forecast period (2019-2032)?
• At what CAGR the patient population is expected to grow by 7MM during the forecast period (2019-2032)?

Current Treatment Scenario, HPV16+ Anogenital Cancers Marketed Drugs, and HPV16+ Anogenital Cancers Emerging Therapies:

• What are the current options for the HPV16+ Anogenital Cancers treatment in addition to the approved therapies?
• What are the current treatment guidelines for the treatment of HPV16+ Anogenital Cancers in the USA, Europe, and Japan?
• What are the HPV16+ Anogenital Cancers marketed drugs and their respective MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, efficacy, etc.?
• How many companies are developing therapies for the treatment of HPV16+ Anogenital Cancers?
• How many therapies are in-development by each company for HPV16+ Anogenital Cancers treatment?
• How many are emerging therapies in mid-stage, and late stage of development for HPV16+ Anogenital Cancers treatment?
• What are the key collaborations (Industry - Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the HPV16+ Anogenital Cancers therapies?
• What are the recent novel therapies, targets, mechanisms of action, and technologies being developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for HPV16+ Anogenital Cancers and its status?
• What are the current challenges faced in drug development?
• What are the key designations that have been granted for the emerging therapies for HPV16+ Anogenital Cancers?
• What are the global historical and forecasted markets of HPV16+ Anogenital Cancers?

Reasons to buy

• The Patient Based HPV16+ Anogenital Cancers Market Forecasting analysis will help in developing business strategies by understanding trends shaping and driving the HPV16+ Anogenital Cancers market
• Organize sales and marketing efforts by identifying the best opportunities for HPV16+ Anogenital Cancers in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom), and Japan
• Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
• Organize sales and marketing efforts by identifying the best opportunities for the HPV16+ Anogenital Cancers market
• To understand the future market competition in the HPV16+ Anogenital Cancers market