Hypoactive Sexual Desire Disorder Market Summary

• The Hypoactive Sexual Desire Disorder Market Size is anticipated to grow with a significant CAGR during the study period (2020-2034).
• Hypoactive Sexual Desire Disorder is defined in the DSM-IV-TR as a persistent or recurrent absence of sexual fantasies and desire for sexual activity. 
• Hypoactive Sexual Desire Disorder treatment involves a multifaceted approach, including sex therapy, psychotherapy, pharmacological interventions, and hormonal therapies. Management strategies for women often include lifestyle modifications, addressing underlying medical or psychiatric conditions, adjusting medications that may affect sexual desire, hormone replacement therapy, and marital or relationship counseling.
• The US Food and Drug Administration (FDA) has approved ADDYI (flibanserin) in 2015 and VYLEESI (bremelanotide) in 2019 for the treatment of acquired, generalized hypoactive sexual desire premenopausal women.
• ADDYI and VYLEESI effectiveness is limited and varies by individual. ADDYI is taken daily and may take several weeks to produce noticeable improvements, while VYLEESI is an on-demand injectable used shortly about 45 minutes before sexual activity. Despite offering different approaches, both medications are only effective in approximately 50–60% of patients, highlighting the ongoing need for more reliable and broadly effective options.
• Freya Pharma Solutions is developing Lybrido, an innovative, on-demand therapy in late-stage trials for FSIAD/Hypoactive Sexual Desire Disorder. With seventeen years of research, the Amsterdam-based company targets a major unmet need with a personalized treatment approach
• Some psychological conditions may be associated with the development of Hypoactive Sexual Desire Disorder, including depression, anxiety and low self-esteem.
• The Hypoactive Sexual Desire Disorder pipeline is severely underdeveloped, reflecting a major unmet need and lack of innovation. Freya Pharma Solutions leads the emerging space, aiming to address both hormonal and psychological drivers of Hypoactive Sexual Desire Disorder.
• Successful launch of Lybrido could revitalize the Hypoactive Sexual Desire Disorder market, opening opportunities for broader awareness, improved access, and expanded indications.

DelveInsight’s "Hypoactive Sexual Desire Disorder Market Insight, Epidemiology, and Market Forecast – 2034" report delivers an in-depth understanding of Hypoactive Sexual Desire Disorder, historical and forecasted epidemiology as well as the Hypoactive Sexual Desire Disorder therapeutics market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The Hypoactive Sexual Desire Disorder market report provides current treatment practices, emerging drugs, Hypoactive Sexual Desire Disorder share of individual therapies, and current and forecasted Hypoactive Sexual Desire Disorder market size from 2020 to 2034, segmented by seven major markets. The report also covers current Hypoactive Sexual Desire Disorder treatment practices/algorithms and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

Hypoactive Sexual Desire Disorder Disease Understanding

Hypoactive Sexual Desire Disorder Overview

Hypoactive sexual desire disorder is defined in the DSM-IV-TR as a persistent or recurrent absence of sexual fantasies and desire for sexual activity, which causes marked personal distress or interpersonal difficulties. Women can benefit from behavioral and pharmacological interventions. The first barrier to providing this benefit is detection and diagnosis of the disorder. However, the private and personal nature of sexual activity and the potential for feelings of shame, inadequacy, and embarrassment create unique challenges to effective communication about sexual health for both patient and physician. These barriers, combined with lack of awareness of the prevalence and opportunity to treat Hypoactive Sexual Desire Disorder on the part of both patient and clinician, are among those responsible for current underdetection and undertreatment. Symptoms of Hypoactive Sexual Desire Disorder include decreased spontaneous sexual thoughts or fantasies, decreased responsiveness to stimulation, inability to maintain interest through sex, and loss of desire to initiate sex. Women with Hypoactive Sexual Desire Disorder may also avoid situations that could lead to sexual activity. 

Hypoactive Sexual Desire Disorder Diagnosis

Hypoactive Sexual Desire Disorder is diagnosed based on a persistent or recurrent lack of sexual desire or thoughts that causes significant distress to the individual and lasts for at least six months. The diagnosis requires ruling out other causes such as medical conditions, medication side effects, psychiatric disorders, or relationship issues. In women, Hypoactive Sexual Desire Disorder is now classified under Female Sexual Interest/Arousal Disorder (FSIAD) in the DSM-5, though the term Hypoactive Sexual Desire Disorder is still widely used, especially in clinical trials. A detailed sexual and psychosocial history is essential, often supported by validated screening tools such as the Decreased Sexual Desire Screener (DSDS) or the Female Sexual Function Index (FSFI). Clinicians must also assess hormonal status, mental health, and interpersonal factors to determine whether the condition is lifelong or acquired, generalized or situational. Proper diagnosis involves distinguishing Hypoactive Sexual Desire Disorder from normal fluctuations in desire and from desire changes secondary to other disorders, ensuring the condition is not better explained by other factors.

Further details related to diagnosis will be provided in the report…

Hypoactive Sexual Desire Disorder Treatment

The treatment of Hypoactive Sexual Desire Disorder involves a personalized, multidisciplinary approach that addresses biological, psychological, and relational factors. First-line treatment often includes psychosexual therapy or counseling, particularly when relationship issues, past trauma, or psychological conditions like depression or anxiety contribute to the disorder. Cognitive-behavioral therapy (CBT) and mindfulness-based interventions have also shown benefit in improving sexual desire and reducing distress. Hormonal therapies, such as testosterone supplementation, may be considered off-label in postmenopausal women, though long-term safety and efficacy data are still being evaluated. Treatment plans often combine behavioral strategies, education, and pharmacologic options when appropriate. Lifestyle modifications, such as stress management, regular exercise, and improved sleep, can also support overall sexual health. The choice of therapy depends on individual needs, the underlying cause of Hypoactive Sexual Desire Disorder, and whether the patient is pre- or postmenopausal. Regular follow-up is essential to monitor progress and adjust treatment accordingly.

Further details related to treatment will be provided in the report…

Hypoactive Sexual Desire Disorder Epidemiology

The Hypoactive Sexual Desire Disorder epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by the total prevalent cases of Hypoactive Sexual Desire Disorder, gender-specific cases of Hypoactive Sexual Desire Disorder, age-specific cases of Hypoactive Sexual Desire Disorder, and total treated cases of Hypoactive Sexual Desire Disorder in the 7MM market covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2020 to 2034.

• Among the 7MM, the United States has captured the highest patient share of Hypoactive Sexual Desire Disorder in 2024.
• Hypoactive Sexual Desire Disorder is a common condition across adult age groups, peaking in 45–64 age group, likely due to hormonal changes, menopause-related symptoms, and psychosocial factors.
• Hypoactive Sexual Desire Disorder affects approximately 10% of all pre-menopausal women in the United States, or about 6 million women.
• As per the analysis, females are affected more with Hypoactive Sexual Desire Disorder as compared to males. 

Hypoactive Sexual Desire Disorder Drug Chapters

The drug chapter segment of the Hypoactive Sexual Desire Disorder report encloses a detailed analysis Hypoactive Sexual Desire Disorder marketed and emerging Hypoactive Sexual Desire Disorder pipeline drugs. It also deep dives into Hypoactive Sexual Desire Disorder’s pivotal clinical trial details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations. 

Currently, ADDYI (Sprout Pharmaceuticals) and VYLEESI (Cosette Pharmaceuticals) are the only two FDA-approved medications for treating Hypoactive Sexual Desire Disorder. key company for their respective drug candidate include Freya Pharma Solutions (Lybrido), among others. The drug chapter also helps understand the Hypoactive Sexual Desire Disorder clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details, and the latest news and press releases.

Hypoactive Sexual Desire Disorder Marketed Drugs

ADDYI (flibanserin): Sprout Pharmaceuticals

ADDYI is a non-hormonal pill for acquired, generalized Hypoactive Sexual Desire Disorder for premenopausal women. Flibanserin selectively targets central serotonin postsynaptic receptors, exhibiting both agonistic and antagonistic effects on 5-HT1A and 5-HT2A, respectively.

The US Food and Drug Administration (FDA) has warned Sprout Pharmaceuticals for the second time concerning its promotion of its Hypoactive Sexual Desire Disorder drug ADDYI. The agency also sent a warning letter to a company for conducting a clinical investigation without submitting an investigational new drug application (IND).

VYLEESI (bremelanotide injection): Cosette Pharmaceuticals

VYLEESI is a melanocortin receptor agonist indicated for the treatment of premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

In January 2024, Cosette Pharmaceuticals has completed the acquisition of VYLEESI from Palatin Technologies, which includes 5 Orange Book listed patents with protection up to 2041. Palatin and Cosette will ensure continued patient and healthcare professional access to VYLEESI throughout the transition period.

Hypoactive Sexual Desire Disorder Emerging Drugs

Lybrido: Freya Pharma Solutions 

Lybrido focuses on treatment for patients with Hypoactive Sexual Desire Disorder, in which low sexual desire results from a central nervous system that is relatively insensitive to sexual cues. In these individuals, exposure to sexual stimuli (internal or external) fails to trigger activation of the brain’s sexual excitatory mechanisms. Lybrido contains sildenafil (a phosphodiesterase type 5 inhibitor) with a time-release coating and an outer testosterone shell. A Phase III trial for Lybrido is currently in preparation. 

• In February 2024, Freya Pharma’s innovation Lybrido, a dual release combination tablet containing testosterone for sublingual administration, and sildenafil for oral administration, was presented as a very promising future treatment for women diagnosed with Female Sexual Interest/Arousal Disorder (FSIAD) or Hypoactive Sexual Desire Disorder. 

• In June 2023, Freya Pharma Solutions announced that the US FDA has responded with interest and provided valuable input regarding Freya Pharma’s request for advice on the US Clinical Development Program of Lybrido for the treatment of FSIAD or Hypoactive Sexual Desire Disorder.

Note: Detailed emerging therapies assessment will be provided in the final report....

Hypoactive Sexual Desire Disorder Drug Class Insight

Melanocortin receptor agonist 

Melanocortin receptor agonists are a class of drugs that activate melanocortin receptors, particularly the melanocortin-4 receptor (MC4R), which plays a key role in regulating sexual desire through central nervous system pathways. These agents stimulate MC4R in the hypothalamus, enhancing dopaminergic signaling and promoting sexual motivation and arousal. Unlike hormonal treatments, melanocortin agonists act directly on neural circuits involved in sexual behavior, offering a non-hormonal therapeutic approach. The most notable example is bremelanotide (Vyleesi), the first FDA-approved melanocortin receptor agonist for the treatment of acquired, generalized Hypoactive Sexual Desire Disorder in premenopausal women. Melanocortin receptor agonists offer a unique, on-demand option for women seeking non-daily, non-hormonal treatment for Hypoactive Sexual Desire Disorder, especially those for whom traditional hormone-based therapies are unsuitable.

Serotonin receptor

Serotonin-containing cell bodies are found in the raphe nucleus in the brainstem and in nerve endings distributed diffusely throughout the brain (Julius, 1991). Serotonin has been implicated in sleep, modulation of circadian rhythms, eating, and arousal. Serotonin also has hormone-like effects when released in the bloodstream, regulating smooth muscle contraction and affecting the platelet aggregating and immune systems.

Serotonin receptors are classified into four subtypes: 5-HT1 to 5-HT4, with a further subdivision of the 5-HT1 subtypes. Recall that the 5-HT3 receptor is ionotropic. The other 5-HT receptors exhibit the typical seven transmembrane-spanning segments, and all couple to G proteins to exert their effects. For example, 5-HT1a, 5-HT1b, 5HT1d, and 5HT4 either activate or inhibit adenylyl cyclase. 5-HT1c and 5-HT2 receptors preferentially stimulate activation of phospholipase C to produce increased intracellular levels of diacylglycerol and inositol 1,4,5-trisphosphate.

Hypoactive Sexual Desire Disorder Market Outlook

The therapeutic landscape for Hypoactive Sexual Desire Disorder still relies chiefly on behavioral interventions and a pair of centrally acting agents flibanserin (a daily 5‑HT₁A agonist/5‑HT₂A antagonist) and bremelanotide (melanocortin‑4 receptor agonist)—both approved only for pre‑menopausal women. Although these drugs can improve desire, their modest efficacy, required lifestyle adjustments (night‑time dosing for flibanserin; injections for bremelanotide) and notable adverse‑effect profiles mean that many patients discontinue or never start pharmacologic therapy. Hormonal approaches (e.g., off‑label transdermal testosterone or intranasal oxytocin) offer alternatives for post‑menopausal women, yet long‑term safety and regulatory acceptance remain unsettled, underscoring the need for newer, more durable solutions.

Encouragingly, pipeline activity is shifting toward multimodal, precision treatments that address both neurochemical imbalance and inhibitory pathways underlying low desire. Late‑stage candidates include Lybrido. Three Phase II studies (two for Lybridos and one for Lybrido) have been conducted by company at 16 research sites in the United States. The efficacy and safety of various doses of testosterone, sildenafil, buspirone and combination therapies (testosterone + sildenafil, testosterone + buspirone) were tested in 497 women with Hypoactive Sexual Desire Disorder to determine the change in satisfying sexual events (SSEs) over a period of eight weeks. 

Despite the advances, only two medications have regulatory approval, and none yet address post‑menopausal or male Hypoactive Sexual Desire Disorder comprehensively. As awareness for Hypoactive Sexual Desire Disorder is growing and as its psychological and relational impact becomes clearer, continued investment in mechanistically targeted trials is essential to deliver safer, more effective, and more inclusive treatments for the millions of individuals affected by Hypoactive Sexual Desire Disorder.

Further details will be provided in the report….

Hypoactive Sexual Desire Disorder Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2025–2034. The landscape of Hypoactive Sexual Desire Disorder treatment has experienced a profound transformation with the uptake of novel medicines. These innovative therapies are redefining standards of care. 

Hypoactive Sexual Desire Disorder Pipeline Development Activities

The Hypoactive Sexual Desire Disorder pipeline report provides insights into different Hypoactive Sexual Desire Disorder clinical trials within Phase III, and Phase II stage. It also analyzes key players involved in developing targeted therapeutics.

Hypoactive Sexual Desire Disorder Pipeline Development Activities

The Hypoactive Sexual Desire Disorder clinical trials within report covers detailed information on collaborations, acquisitions and mergers, licensing, and patent details for Hypoactive Sexual Desire Disorder emerging therapies. 

KOL- Views on Hypoactive Sexual Desire Disorder Market Report

To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Some of the leaders like MD, Professor and Vice Chair of the Department of Rheumatology and Director, PhD, and others. Their opinion helps to understand and validate current and emerging therapies and treatment patterns or Hypoactive Sexual Desire Disorder market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Delveinsight’s analysts connected with 15+ KOLs to gather insights; however, interviews were conducted with 5+ KOLs in the 7MM. Centers such as the Washington University School of Medicine, University Medical Center Hamburg-Eppendorf, and University Graduate School of Medicine etc. were contacted. Their opinion helps understand and validate Hypoactive Sexual Desire Disorder epidemiology and market trends.

Hypoactive Sexual Desire Disorder Report Qualitative Analysis

We perform qualitative and market intelligence analysis using various approaches, such as SWOT and conjoint analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst’s discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, designation, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The analyst analyzes multiple emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry.

In efficacy, the trial’s primary and secondary outcome measures are evaluated.

Further, the therapies’ safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials.

Hypoactive Sexual Desire Disorder Market Access and Reimbursement

Reimbursement may be referred to as the negotiation of a price between a manufacturer and a payer that allows the manufacturer access to the market. It is provided to reduce the high costs and make the essential drugs affordable. Health technology assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug. In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs, including Medicare, Medicaid, Health Insurance Program (CHIP), and the state and federal health insurance marketplaces, are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs) and third-party organizations that provide services and educational programs to aid patients are also present.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Further detailed analysis will be provided in the report….

Scope of the Hypoactive Sexual Desire Disorder Market Report

• The report covers a descriptive overview of Hypoactive Sexual Desire Disorder, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
• Comprehensive insight has been provided into Hypoactive Sexual Desire Disorder epidemiology and treatment.
• Additionally, an all-inclusive account of both the current and emerging therapies for Hypoactive Sexual Desire Disorder is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
• A detailed review of the Hypoactive Sexual Desire Disorder market; historical and forecasted is included in the report, covering the 7MM drug outreach.
• The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Hypoactive Sexual Desire Disorder market. 

Hypoactive Sexual Desire Disorder Market Report Insights

• Hypoactive Sexual Desire Disorder Patient Population
• Hypoactive Sexual Desire Disorder Therapeutic Approaches
• Hypoactive Sexual Desire Disorder Pipeline Analysis
• Hypoactive Sexual Desire Disorder Market Size and Trends
• Hypoactive Sexual Desire Disorder Market Opportunities
• Impact of Upcoming Hypoactive Sexual Desire Disorder Therapies

Hypoactive Sexual Desire Disorder Market Report Key Strengths

• Ten Years Forecast
• 7MM Coverage 
• Hypoactive Sexual Desire Disorder Epidemiology Segmentation
• Key Cross Competition 
• Highly Analyzed Market
• Hypoactive Sexual Desire Disorder Drugs Uptake

Hypoactive Sexual Desire Disorder Market Report Assessment

• Current Hypoactive Sexual Desire Disorder Treatment Practices
• Hypoactive Sexual Desire Disorder Unmet Needs
• Hypoactive Sexual Desire Disorder Pipeline Product Profiles
• Hypoactive Sexual Desire Disorder Market Attractiveness
• Qualitative Analysis (SWOT and Conjoint Analysis)
• Hypoactive Sexual Desire Disorder Market Drivers
• Hypoactive Sexual Desire Disorder Market Barriers

FAQs

• What was the Hypoactive Sexual Desire Disorder market share (%) distribution in 2020 and what it would look like in 2034?
• What would be the Hypoactive Sexual Desire Disorder total market size as well as market size by therapies across the 7MM during the study period (2020–2034)?
• What are the key findings about the market across the 7MM and which country will have the largest Hypoactive Sexual Desire Disorder market size during the study period (2020–2034)?
• At what CAGR, the Hypoactive Sexual Desire Disorder market is expected to grow at the 7MM level during the study period (2020–2034)?
• What would be the Hypoactive Sexual Desire Disorder market growth till 2034?
• What are the disease risks, burdens, and unmet needs of Hypoactive Sexual Desire Disorder?
• What is the historical Hypoactive Sexual Desire Disorder patient pool in the United States, EU4 (Germany, France, Italy, and Spain), and the UK, and Japan?
• What will be the growth opportunities across the 7MM concerning the patient population of Hypoactive Sexual Desire Disorder?
• Amon the 7MM which country would have the most prevalent cases of Hypoactive Sexual Desire Disorder?
• At what CAGR the population is expected to grow across the 7MM during the study period (2020–2034)?
• How many companies are developing therapies for the treatment of Hypoactive Sexual Desire Disorder?
• How many emerging therapies are in the mid-stage and late stage of development for the treatment of Hypoactive Sexual Desire Disorder?
• What are the key collaborations (industry–industry, industry-academia), Mergers and acquisitions, and licensing activities related to Hypoactive Sexual Desire Disorder therapies? 
• What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitations of existing therapies? 
• What are the key designations that have been granted for the emerging therapies for Hypoactive Sexual Desire Disorder?
• What are the 7MM historical and forecasted market of Hypoactive Sexual Desire Disorder?

Reasons to buy Hypoactive Sexual Desire Disorder Market Forecast Report

• The report will help in developing business strategies by understanding trends shaping and driving the Hypoactive Sexual Desire Disorder market.
• To understand the future market competition in the Hypoactive Sexual Desire Disorder market and insightful review of the SWOT analysis of Hypoactive Sexual Desire Disorder.
• Organize sales and marketing efforts by identifying the best opportunities for Hypoactive Sexual Desire Disorder in the US, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
• Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
• Organize sales and marketing efforts by identifying the best opportunities for the Hypoactive Sexual Desire Disorder market.
• To understand the future market competition in the Hypoactive Sexual Desire Disorder.