DelveInsight’s, “Integrin Alpha4beta1 Antagonists - Pipeline Insight, 2022,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Integrin Alpha4beta1 Antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Integrin Alpha4beta1 Antagonists: Overview
Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel disease/multiple sclerosis and dry eye disease, respectively. The related integrins α4β7 and α4β1 are therapeutic targets that are expressed on leukocytes and also recognize short peptide sequences, one of which is Leu–Asp–Val (LDV). There is some preclinical evidence that α3β1 (ref.82), α4β1 (ref.83) and α8β1 integrins play a role in pulmonary fibrosis, and that αvβ8 is important in small airway fibrosis associated with chronic obstructive pulmonary fibrosis and asthma.
The companies and academics are working to assess challenges and seek opportunities that could influence Integrin Alpha4beta1 Antagonists R&D. The therapies under development are focused on novel approaches for Integrin Alpha4beta1 Antagonists.
This segment of the Integrin Alpha4beta1 Antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Integrin Alpha4beta1 Antagonists Emerging Drugs
Natalizumab: Biogen
Natalizumab is a monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis. It Binds to the α4-subunit of α4b 1 and α4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptor(s). Currently, it is being evaluated in phase II stage of development to treat Graft-versus-host disease.
AXR 159: AxeroVision
AXR-159 is being developed for the treatment of chronic Dry eyes disease (DED). AXR-270 is being developed for the short-term treatment of DED. Currently, it is in phase II stage of development to treat DED.
Further product details are provided in the report……..
This segment of the report provides insights about the different Integrin Alpha4beta1 Antagonists drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 5+ key companies which are developing the Integrin Alpha4beta1 Antagonists. The companies which have their Integrin Alpha4beta1 Antagonists drug candidates in the most advanced stage, i.e. Phase II include, Biogen.
DelveInsight’s report covers around 5+ products under different phases of clinical development like
Integrin Alpha4beta1 Antagonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Integrin Alpha4beta1 Antagonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Integrin Alpha4beta1 Antagonists drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Integrin Alpha4beta1 Antagonists: Overview
Pipeline Therapeutics
Therapeutic Assessment
Integrin Alpha4beta1 Antagonists – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
PB-006: Polpharma Biologics
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
AXR 159: AxeroVision
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
BIIB 107: Biogen
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
SAS: Feramda
Drug profiles in the detailed report…..
Inactive Products
Integrin Alpha4beta1 Antagonists Key Companies
Integrin Alpha4beta1 Antagonists Key Products
Integrin Alpha4beta1 Antagonists- Unmet Needs
Integrin Alpha4beta1 Antagonists- Market Drivers and Barriers
Integrin Alpha4beta1 Antagonists- Future Perspectives and Conclusion
Integrin Alpha4beta1 Antagonists Analyst Views
Integrin Alpha4beta1 Antagonists Key Companies
Appendix
List of Table
Table 1: Total Products for Integrin Alpha4beta1 Antagonists
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Integrin Alpha4beta1 Antagonists
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Biogen
• AxeroVision
• Polpharma Biologics
• EA Pharma
• BioMAS
• Feramda
