Map Kinase Kinase 1 Inhibitors Pipeline Insight

DelveInsight’s, “MAP Kinase Kinase 1 Inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 6+ companies and 6+ pipeline drugs in MAP Kinase Kinase 1 Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

MAP Kinase Kinase 1 Inhibitors Understanding

MAP Kinase Kinase 1 Inhibitors: Overview

MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF. MEK inhibitors hold promise for use as combination therapies for highly prevalent, genetically defined cancers owing to the critical role that the MAPK pathway plays in the growth and proliferation of many cancer types (including lung cancer, melanoma, pancreatic cancer, colorectal cancer, endometrial cancer, and ovarian cancer).

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence MAP Kinase Kinase 1 Inhibitors R&D. The therapies under development are focused on novel approaches for MAP Kinase Kinase 1 Inhibitors.

MAP Kinase Kinase 1 Inhibitors Emerging Drugs Chapters

This segment of the MAP Kinase Kinase 1 Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

 

MAP Kinase Kinase 1 Inhibitors Emerging Drugs

 

Selumetinib: AstraZeneca

Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). Selumetinib is a non-ATP-competitive mitogen-activated protein kinase kinase 1 and 2 (MEK1 and MEK2) inhibitor.6 By selectively targeting MEK1 and MEK2, selumetinib is able to inhibit oncogenic downstream effects of the Raf-MEK-ERK signaling pathway, which is often overactive in certain types of cancer.

 

Mirdametinib: SpringWorks Therapeutics

Mirdametinib is an oral, allosteric, small molecule MEK inhibitor in development as a monotherapy treatment for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN) and low-grade glioma (LGG), and as a combination therapy for the treatment of several subsets of biomarker-defined metastatic solid tumors. A Phase 2 investigator-initiated trial of mirdametinib in adolescents and adults with NF1-PN showed encouraging efficacy along with a generally well-tolerated safety profile. The U.S. Food and Drug Administration (FDA) and the European Commission granted Orphan Drug designation for mirdametinib for the treatment of NF1, and the FDA granted Fast Track designation for the treatment of patients ≥ 2 years of age with NF1-PN that are progressing or causing significant morbidity.

Further product details are provided in the report……..

MAP Kinase Kinase 1 Inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different MAP Kinase Kinase 1 Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players working on MAP Kinase Kinase 1 Inhibitors

There are approx. 6+ key companies which are developing the MAP Kinase Kinase 1 Inhibitors. The companies which have their MAP Kinase Kinase 1 Inhibitors drug candidates in the most advanced stage, i.e. Phase II include, SpringWorks Therapeutics .

Phases

DelveInsight’s report covers around 6+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

 

MAP Kinase Kinase 1 Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

 

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

MAP Kinase Kinase 1 Inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses MAP Kinase Kinase 1 Inhibitors therapeutic drugs key players involved in developing key drugs.

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging MAP Kinase Kinase 1 Inhibitors drugs.

MAP Kinase Kinase 1 Inhibitors Report Insights

  • MAP Kinase Kinase 1 Inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

MAP Kinase Kinase 1 Inhibitors Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

  • How many companies are developing MAP Kinase Kinase 1 Inhibitors drugs?
  • How many MAP Kinase Kinase 1 Inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of MAP Kinase Kinase 1 Inhibitors?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the MAP Kinase Kinase 1 Inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for MAP Kinase Kinase 1 Inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

MAP Kinase Kinase 1 Inhibitors: Overview

  • Structure
  • Mechanism of Action

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

MAP Kinase Kinase 1 Inhibitors – DelveInsight’s Analytical Perspective

Late Stage Products (Phase III)

  • Comparative Analysis

Selumetinib: AstraZeneca

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

Mirdametinib: SpringWorks Therapeutics

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I and I/II)

  • Comparative Analysis

CS 3006: CStone Pharmaceuticals

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Pre-clinical and Discovery Stage Products

  • Comparative Analysis

REC 4881: Recursion Pharmaceuticals

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

MAP Kinase Kinase 1 Inhibitors Key Companies

MAP Kinase Kinase 1 Inhibitors Key Products

MAP Kinase Kinase 1 Inhibitors- Unmet Needs

MAP Kinase Kinase 1 Inhibitors- Market Drivers and Barriers

MAP Kinase Kinase 1 Inhibitors- Future Perspectives and Conclusion

MAP Kinase Kinase 1 Inhibitors Analyst Views

MAP Kinase Kinase 1 Inhibitors Key Companies

Appendix

List of Table

Table 1: Total Products for MAP Kinase Kinase 1 Inhibitors

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for MAP Kinase Kinase 1 Inhibitors

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type                                                                       

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products

• AstraZeneca
• SpringWorks Therapeutics
• Array BioPharma
• Novartis
• Chongqing Fochon Pharmaceutical
• Recursion Pharmaceuticals
• CStone Pharmaceuticals

 

Forward to Friend

Need A Quote