Microsatellite Stable Colorectal Cancer Pipeline Insight

DelveInsight’s, “Microsatellite Stable Colorectal Cancer – Pipeline Insight, 2022,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Microsatellite Stable Colorectal Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Microsatellite Stable Colorectal Cancer Understanding

Microsatellite Stable Colorectal Cancer: Overview

Colorectal cancer (CRC) is the most common type of cancer. The Microsatellite stable (MSS) Colorectal cancer, which exhibits chromosomal instability and accounts for 85% of tumor. They are caused by mutations in genes that are required to maintain chromosomal stability, leading to the accumulation of gains and losses of chromosomes (aneuploidy) as well as by structural chromosomal rearrangements.


Symptoms

Symptoms may include:


  • Change in bowel habits
  • Abdominal discomfort
  • Rectal Bleeding
  • Change in the consistency of stool
  • Diarrhea and constipation


Treatment

Microsatellite stable colorectal cancer bears fewer signals that alert the immune system to cancer. So checkpoint inhibitors, such as nivolumab, have been unsuccessful in treating MSS colorectal cancer (CRC). Clinical trials have been going on to develop the promising drug for MSS colorectal cancer.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Microsatellite Stable Colorectal Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Microsatellite Stable Colorectal Cancer.

Microsatellite Stable Colorectal Cancer Emerging Drugs Chapters

This segment of the Microsatellite Stable Colorectal Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.


Microsatellite Stable Colorectal Cancer Emerging Drugs


GRANITE: Gritstone Oncology

GRANITE, is a personalized neoantigen-based immunotherapy. It is being evaluated in the Phase 2 portion of a Phase 1/2 clinical study in combination with checkpoint inhibitors for patients with microsatellite stable colorectal cancer (MSS CRC) who have progressed on FOLFOX/FOLFIRI therapy and a second cohort for patients with gastro-esophageal cancer who have progressed on chemotherapy. GRANITE was granted Fast Track designation by the U.S. Food and Drug Administration for the treatment of MSS CRC.


MK7123-034: Merck Sharp & Dohme Corp.

The study is currently in phase II to assess the efficacy and safety of navarixin (MK-7123) in combination with pembrolizumab (MK-3475) in adults with one of three types of solid tumors: Programmed Death-Ligand 1 (PD-L1) positive refractory non-small cell lung cancer (NSCLC), castration resistant prostate cancer (CRPC) or microsatellite stable (MSS) colorectal cancer (CRC).

Further product details are provided in the report……..

Microsatellite Stable Colorectal Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Microsatellite Stable Colorectal Cancer drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in Microsatellite Stable Colorectal Cancer

There are approx. 10+ key companies which are developing the therapies for Microsatellite Stable Colorectal Cancer. The companies which have their Microsatellite Stable Colorectal Cancer drug candidates in the mid to advanced stage, i.e. phase III and Phase II include, Merck Sharp & Dohme Corp. and others.

Phases

DelveInsight’s report covers around 10+ products under different phases of clinical development like

  • Mid-stage products (Phase II )
  • Early-stage products ( Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidate
  • Route of Administration


Microsatellite Stable Colorectal Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Subcutaneous
  • Intravenous
  • Oral
  • Intramuscular
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Small molecules
  • Natural metabolites
  • Monoclonal antibodies
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Microsatellite Stable Colorectal Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Microsatellite Stable Colorectal Cancer therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Microsatellite Stable Colorectal Cancer drugs.

Microsatellite Stable Colorectal Cancer Report Insights

  • Microsatellite Stable Colorectal Cancer Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Microsatellite Stable Colorectal Cancer Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Microsatellite Stable Colorectal Cancer drugs?
  • How many Microsatellite Stable Colorectal Cancer drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Microsatellite Stable Colorectal Cancer?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Microsatellite Stable Colorectal Cancer therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Microsatellite Stable Colorectal Cancer and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Microsatellite Stable Colorectal Cancer: Overview

  • Causes
  • Mechanism of Action

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Microsatellite Stable Colorectal Cancer – DelveInsight’s Analytical Perspective

In-depth Commercial Assessment

  • Microsatellite Stable Colorectal Cancer companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Microsatellite Stable Colorectal Cancer Collaboration Deals

  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Mid Stage Products (Phase III)

  • Comparative Analysis

MK7123-034: Merck Sharp & Dohme Corp.

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I/II)

  • Comparative Analysis

GRANITE: Gritstone Oncology

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Pre-clinical and Discovery Stage Products

  • Comparative Analysis
  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Microsatellite Stable Colorectal Cancer Key Companies

Microsatellite Stable Colorectal Cancer Key Products

Microsatellite Stable Colorectal Cancer- Unmet Needs

Microsatellite Stable Colorectal Cancer- Market Drivers and Barriers

Microsatellite Stable Colorectal Cancer- Future Perspectives and Conclusion

Microsatellite Stable Colorectal Cancer Analyst Views

Microsatellite Stable Colorectal Cancer Key Companies

Appendix

List of Table

Table 1: Total Products for Microsatellite Stable Colorectal Cancer

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Microsatellite Stable Colorectal Cancer

Figure 2: Late Stage Products                              

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products    

• Gritstone Oncology

• Merck Sharp & Dohme Corp.

• Arrys Therapeutics

• NeoImmuneTech

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