Toll Like Receptor Modulators Pipeline Insight

DelveInsight’s, “Toll-Like Receptor Modulators - Pipeline Insight, 2022,” report provides comprehensive insights about 50+ companies and 60+ pipeline drugs in Toll-Like Receptor Modulators pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Toll-Like Receptor Modulators Understanding

Toll-Like Receptor Modulators: Overview

The innate immune system is a central figure in protecting the human body against microbes, allergens, and cancer. The TLR family and its downstream intracellular signaling molecules play essential roles in innate immunity. Activation of these signaling pathways leads to the expression of various anti- as well as pro-inflammatory molecules that regulate metabolism and homeostasis. Changes or defects in this intricate system result in infectious and inflammatory diseases, including cancer, atherosclerosis, and diabetes. Thus, TLR family members represent important therapeutic targets for the treatment of these disorders. Natural products have been and will continue to be used as TLR agonists or antagonists in the prevention and treatment of these diseases.


"Toll-Like Receptor Modulators - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Toll-Like Receptor Modulators pipeline landscape is provided which includes the disease overview and Toll-Like Receptor Modulators treatment guidelines. The assessment part of the report embraces, in depth Toll-Like Receptor Modulators commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Toll-Like Receptor Modulators collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Toll-Like Receptor Modulators R&D. The therapies under development are focused on novel approaches to treat/improve Toll-Like Receptor Modulators.

Toll-Like Receptor Modulators Emerging Drugs Chapters

This segment of the Toll-Like Receptor Modulators report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.


Toll-Like Receptor Modulators Emerging Drugs


Cobitolimod: InDex Pharmaceuticals

Cobitolimod is part of InDex Pharmaceuticals’ DNA-based ImmunoModulatory Sequence (DIMS) platform. It is administered locally in the large intestine, where the substance binds to Toll-like receptor 9 (TLR9) present inside immune cells as well as on the surface of epithelial cells. The binding triggers the cells to product anti-inflammatory cytokines, agents that play an important role in reducing the inflammation and healing the wounds in the large intestine caused by UC. It is currently in Phase III stage of development for the treatment of Ulcerative colitis and is being developed by InDex Pharmaceuticals.


Tilsotolimod: Idera Pharmaceuticals

Tilsotolimod is an investigational, synthetic Toll-like receptor 9 agonist. Intratumoral injection of tilsotolimod has been shown to promote both innate (Type-I IFN, antigen presentation) and adaptive (T cells) immune activation. Tumors with an active immune response appear to respond better to checkpoint inhibitors (CPIs) than those that exclude or inhibit anti-tumor immune cells. Tilsotolimod in combination with CPIs may increase the number of patients who benefit from immunotherapy.

Tilsotolimod has received both Fast Track designation and Orphan Drug designation from the FDA and is being evaluated in multiple tumor types and in combination with multiple checkpoint inhibitors.

Further product details are provided in the report……..

Toll-Like Receptor Modulators: Therapeutic Assessment

This segment of the report provides insights about the different Toll-Like Receptor Modulators drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in Toll-Like Receptor Modulators

There are approx. 50+ key companies which are developing the therapies for Toll-Like Receptor Modulators. The companies which have their Toll-Like Receptor Modulators drug candidates in the most advanced stage, i.e. Phase III include, InDex Pharmaceuticals.

Phases

DelveInsight’s report covers around 60+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Toll-Like Receptor Modulators pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • Intravenous
  • Subcutaneous
  • Topical.
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Toll-Like Receptor Modulators: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Toll-Like Receptor Modulators therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Toll-Like Receptor Modulators drugs.

Toll-Like Receptor Modulators Report Insights

  • Toll-Like Receptor Modulators Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Toll-Like Receptor Modulators Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Toll-Like Receptor Modulators drugs?
  • How many Toll-Like Receptor Modulators drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Toll-Like Receptor Modulators?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Toll-Like Receptor Modulators therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Toll-Like Receptor Modulators and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Toll-Like Receptor Modulators: Overview

  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Late Stage Products (Phase III)

  • Comparative Analysis

Cobitolimod: InDex Pharmaceuticals

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

PUL-042: Pulmotect

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Early stage products (Phase I)

  • Comparative Analysis

E-6742: Eisai

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Preclinical stage products

  • Comparative Analysis

HT-003: Hoth Therapeutics

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Toll-Like Receptor Modulators Key Companies

Toll-Like Receptor Modulators Key Products

Toll-Like Receptor Modulators- Unmet Needs

Toll-Like Receptor Modulators- Market Drivers and Barriers

Toll-Like Receptor Modulators- Future Perspectives and Conclusion

Toll-Like Receptor Modulators Analyst Views

Toll-Like Receptor Modulators Key Companies

Appendix

List of Table

Table 1: Total Products for Toll-Like Receptor Modulators

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Toll-Like Receptor Modulators

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products

• InDex Pharmaceuticals

• Idera Pharmaceuticals

• Eisai

• Pulmotect

• Oncovir

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