VRAYLAR, Emerging Drug Insight

“VRAYLAR, Market Size, Forecast, and Emerging Insight – 2032” report offers an in-depth analysis of both market and emerging insights regarding VRAYLAR for the treatment of Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) in seven major markets. A detailed picture of the VRAYLAR in 7MM, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan, for the study period 2019 –2032 is provided in this report, along with a detailed description of the VRAYLAR. The report provides insights about the mechanism of action, dosage, and administration, as well as research and development, including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments, including the VRAYLAR market forecast analysis in 7MM, SWOT, analyst views, a comprehensive overview of market competitors, and a brief about other emerging therapies.

Drug Summary

VRAYLAR, also known as Cariprazine, is an oral, once-daily atypical antipsychotic. It is a potent central dopamine D3 and D2 receptor partial agonist, which preferentially binds to the D3 receptor. It also has partial agonist activity at serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Pharmacodynamic studies with cariprazine have shown that it acts as a partial agonist with a high binding affinity at dopamine D3, dopamine D2, and serotonin 5-HT1A receptors. Cariprazine demonstrated up to eightfold greater in vitro affinity for dopamine D3 vs. D2 receptors. Cariprazine also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors with high and moderate binding affinity, respectively, as well as it binds to the histamine H1 receptors. It shows a lower binding affinity to the serotonin 5-HT2C and α1A-adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors.

It was discovered and co-developed by Gedeon Richter and is licensed to Actavis, now Allergan, in the US and Canada. For more than a decade, both companies have conducted over 20 clinical trials enrolling thousands of patients worldwide to evaluate the efficacy and safety of cariprazine for patients suffering from a broad range of mental health illnesses.

Scope of the Report

The report provides insights into:

• A comprehensive product overview including the VRAYLAR description, mechanism of action, dosage and administration, research and development activities in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD).
• Elaborated details on VRAYLAR regulatory milestones and other development activities have been provided in this report.
• The report also highlights the VRAYLAR research and development activities in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) across the United States, Europe, and Japan.
• The report also covers the patent information with expiry timeline around VRAYLAR.
• The report contains forecasted sales of VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) till 2032.
• Comprehensive coverage of the late-stage emerging therapies for Treatment-Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD).
• The report also features the SWOT analysis with analyst views for VRAYLAR in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD).

Methodology

The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight’s team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities' websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals, and access to available databases.

VRAYLAR Analytical Perspective by DelveInsight

• In-depth VRAYLAR Market Assessment

This report provides a detailed market assessment of VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) in seven major markets, i.e., the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. This segment of the report provides forecasted sales data from 2023 to 2032.

• VRAYLAR Clinical Assessment

The report provides the clinical trials information of VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD), covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights 

• In the coming years, the market scenario for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.  
• The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence VRAYLAR dominance.
• Other emerging products for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD) are expected to give tough market competition to VRAYLAR, and the launch of late-stage emerging therapies in the near future will significantly impact the market.
• A detailed description of regulatory milestones and developmental activities provides the current development scenario of VRAYLAR in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD).
• Our in-depth analysis of the forecasted sales data of VRAYLAR from 2023 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of VRAYLAR in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD).

Key Questions

• What is VRAYLAR's product type, route of administration, and mechanism of action?
• What is the clinical trial status of the study related to VRAYLAR in Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD), and the study completion date?
• What are the key collaborations, mergers, acquisitions, licensing, and other activities related to the VRAYLAR development?
• What are the key designations that have been granted to VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD)?
• What is the forecasted market scenario of VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD)?
• What are the forecasted sales of VRAYLAR in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan? 
• What are the other emerging products available, and how are these giving competition to VRAYLAR for Treatment Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD)?
• Which are the late-stage emerging therapies under development for the treatment of Treatment-Resistant Depression (TRD), Bipolar Depression (BD), and Major Depressive Disorder (MDD)?