DREAMM-6: Safety and tolerability of belantamab mafodotin in combination with bortezomib/dexamethasone in relapsed/refractory multiple myeloma (RRMM)
Abstract No : 8502
Abstract Type : Oral Abstract Session
Indication : Multiple Myeloma
Intervention : Belantamab mafodotin
Company : GlaxoSmithKline
Technology : BCMA Inhibitor
Results:
As of February 6, 2020, 52 patients were enrolled: 6 patients were enrolled at 2.5 mg/kg single dose and 7 at 3.4 mg/kg single dosing in Part 1, and 45 patients in Part 2. No dose-limiting toxicities were observed. Corneal events (including keratopathy, blurred vision, and dry eye) and thrombocytopenia were the most frequently reported AEs and were clinically manageable.
Conclusion:
In DREAMM-6, preliminary data demonstrate that the combination of belantamab mafodotin and BorDex has an acceptable safety profile, with no new safety signals identified. Funding: GlaxoSmithKline (207497). Drug linker technology licensed from Seattle Genetics; monoclonal antibody produced using POTELLIGENT Technology licensed from BioWa.
Commentary:
Huge potential for belantamab mafodotin as combination therapy in patients with earlier stages of multiple myeloma agent owing to its promising response data and acceptable safety profile
