Treatment-Resistant Hypertension (TRH) is a form of high blood pressure that remains above target levels despite the use of at least three different antihypertensive medications at optimal doses, including a diuretic. It may also include patients whose blood pressure is controlled but only with four or more medications.
<h2 dir="ltr">Epidemiology Segmentation</h2>
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Total diagnosed prevalent cases&nbsp;
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Gender-specific diagnosed prevalent cases&nbsp;
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Age-specific diagnosed prevalent cases&nbsp;
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<h3 dir="ltr"><a href="https://www.delveinsight.com/report-store/resistant-hypertension-epidemiology-forecast">Treatment-Resistant Hypertension Epidemiology</a></h3>
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In 2024, there were approximately 13,193,000 diagnosed prevalent cases of Treatment-Resistant Hypertension across the 7MM.
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In 2024, the U.S. had approximately 7,365,300 diagnosed prevalent cases of Treatment-Resistant Hypertension, with numbers expected to rise by 2034.
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In Japan, females accounted for about 55% of gender-specific cases in 2024, a share expected to grow by 2034.
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In the U.S., the highest prevalence in 2024 was among adults aged 60+, with ~2,732,600 cases; the lowest was in the 18&ndash;39 age group.
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<h3 dir="ltr"><a href="https://www.delveinsight.com/report-store/treatment-resistant-hypertension-market">Treatment-Resistant Hypertension Market</a></h3>
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In 2024, the U.S. led the Treatment-Resistant Hypertension market in the 7MM with ~USD 6,210 million, expected to grow by 2034.
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Calcium Channel Blockers (CCBs) had the largest market share in the 7MM, generating ~USD 2,110 million in 2024.
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Among EU4 and the UK, Germany had the highest market share, while the UK had the lowest.
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Japan&rsquo;s market was valued at ~USD 259 million in 2024 and is projected to grow significantly by 2034.
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In the U.S., CCBs generated the highest revenue among all therapies in 2024.
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<h3 dir="ltr">Treatment-Resistant Hypertension Market Drivers</h3>
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Increasing rates of hypertension, especially among older adults, are driving demand for advanced treatment options.
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Innovations such as mineralocorticoid receptor antagonists and device-based interventions (e.g., renal denervation) are expanding treatment possibilities.
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<h3 dir="ltr">Treatment-Resistant Hypertension Market Barriers</h3>
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Non-compliance with multi-drug regimens significantly limits treatment effectiveness.
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Many patients remain undiagnosed or misclassified, delaying proper treatment and reducing market penetration.
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<h3 dir="ltr">Treatment-Resistant Hypertension Key Therapies</h3>
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Baxdrostat (CIN-107)
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Lorundrostat (MLS-101)
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MANP
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Tonlamarsen (ION904)
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REGN5381
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Zilebesiran (ALN-AGT01)
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And others.&nbsp;
<h3 dir="ltr">Treatment-Resistant Hypertension Key Players</h3>
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AstraZeneca
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Mineralys Therapeutics
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E-Star BioTech
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Ionis Pharmaceuticals
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Kardiga
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Regeneron Pharmaceuticals
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Alnylam Pharmaceuticals
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Roche
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Idorsia Pharmaceutical
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And others.

Treatment-Resistant Hypertension Market

Treatment-Resistant Hypertension Symptoms, Treatment, epidemiology, companies, drugs, infographic is a short guide to understand the problem and market landscape