Acute On Chronic Liver Failure Aclf Epidemiology Forecast

DelveInsight's 'Acute On Chronic Liver Failure (ACLF) - Epidemiology Forecast to 2030' report delivers an in-depth understanding of the disease, historical and forecasted Acute On Chronic Liver Failure (ACLF) epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Geographies Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2017-2030

Acute On Chronic Liver Failure (ACLF) Understanding

The DelveInsight Acute On Chronic Liver Failure (ACLF) epidemiology report gives a thorough understanding of the Acute On Chronic Liver Failure (ACLF) by including details such as disease definition, symptoms, causes, pathophysiology, and diagnosis. It also provides treatment algorithms and treatment guidelines for Acute On Chronic Liver Failure (ACLF) in the US, Europe, and Japan. The report covers the detailed information of the Acute On Chronic Liver Failure (ACLF) epidemiology scenario in seven major countries (US, EU5, and Japan).

Acute On Chronic Liver Failure (ACLF) Epidemiology Perspective by DelveInsight

The Acute On Chronic Liver Failure (ACLF) epidemiology division provides insights about historical and current patient pool and forecasted trend for every seven major countries. The Acute On Chronic Liver Failure (ACLF) epidemiology data are studied through all possible division to give a better understanding of the Disease scenario in 7MM. The Acute On Chronic Liver Failure (ACLF) epidemiology segment covers the epidemiology data in the US, EU5 countries (Germany, Spain, Italy, France, and the UK), and Japan from 2017 to 2030. It also helps to recognize the causes of current and forecasted trends by exploring numerous studies, survey reports and views of key opinion leaders.

Acute On Chronic Liver Failure (ACLF) Detailed Epidemiology Segmentation

The Acute On Chronic Liver Failure (ACLF) epidemiology covered in the report provides historical as well as forecasted Acute On Chronic Liver Failure (ACLF) epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom) and Japan from 2017 to 2030.


The DelveInsight Acute On Chronic Liver Failure (ACLF) report also provides the epidemiology trends observed in the 7MM during the study period, along with the assumptions undertaken. The calculated data are presented with relevant tables and graphs to give a clear view of the epidemiology at first sight.

Scope of the Report

  • The Acute On Chronic Liver Failure (ACLF) report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns
  • The Acute On Chronic Liver Failure (ACLF) Epidemiology Report and Model provide an overview of the risk factors and global trends of Acute On Chronic Liver Failure (ACLF) in the seven major markets (7MM:US, France, Germany, Italy, Spain, UK, and Japan)
  • The report provides insight about the historical and forecasted patient pool of Acute On Chronic Liver Failure (ACLF) in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan
  • The report helps to recognize the growth opportunities in the 7MM with respect to the patient population
  • The report assesses the disease risk and burden and highlights the unmet needs of Acute On Chronic Liver Failure (ACLF)
  • The report provides the segmentation of the Acute On Chronic Liver Failure (ACLF) epidemiology

Report Highlights

  • 11-Year Forecast of Acute On Chronic Liver Failure (ACLF) epidemiology
  • 7MM Coverage
  • Total Cases of Acute On Chronic Liver Failure (ACLF)
  • Total Cases of Acute On Chronic Liver Failure (ACLF) according to segmentation
  • Diagnosed cases of Acute On Chronic Liver Failure (ACLF)

KOL- Views

We interview, KOLs and SME's opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps to understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered

  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Acute On Chronic Liver Failure (ACLF)?
  • What are the key findings pertaining to the Acute On Chronic Liver Failure (ACLF) epidemiology across 7MM and which country will have the highest number of patients during the forecast period (2017-2030)?
  • What would be the total number of patients of Acute On Chronic Liver Failure (ACLF) across the 7MM during the forecast period (2017-2030)?
  •  Among the EU5 countries, which country will have the highest number of patients during the forecast period (2017-2030)?
  • At what CAGR the patient population is expected to grow in 7MM during the forecast period (2017-2030)?
  • What is the disease risk, burden and unmet needs of the Acute On Chronic Liver Failure (ACLF)?
  • What are the currently available treatments of Acute On Chronic Liver Failure (ACLF)?

Reasons to buy

  • The Acute On Chronic Liver Failure (ACLF) Epidemiology report will allow the user to -
  • Develop business strategies by understanding the trends shaping and driving the global Acute On Chronic Liver Failure (ACLF) market
  • Quantify patient populations in the global Acute On Chronic Liver Failure (ACLF) market to improve product design, pricing, and launch plans
  • Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Acute On Chronic Liver Failure (ACLF) therapeutics in each of the markets covered
  • Understand the magnitude of Acute On Chronic Liver Failure (ACLF) population by its epidemiology
  • The Acute On Chronic Liver Failure (ACLF) Epidemiology Model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources

Key Assessments

  • Patient Segmentation
  • Disease Risk and Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population

1 Executive Summary of Acute on Chronic Liver Failure

2 ACLF Epidemiology Overview at a Glance

2.1 Patient Share (%) Distribution of ACLF in 2017

2.2 Patient Share (%) Distribution of ACLF in 2030

3 Disease Background and Overview

3.1 Introduction

3.2 Heterogeneity of definitions

3.3 Types of ACLF

3.4 Clinical characteristics and pathophysiology

3.5 Diagnosis of ACLF

3.6 ACLF biomarkers

4 Country-wise Epidemiology of Acute-on-Chronic Liver Failure (ACLF)

4.1 Assumptions and Rationale: 7MM

5 Epidemiology and Patient Population

5.1 Key Findings

5.2 United States

5.2.1 Cases of Acute-on-chronic liver failure (ACLF) in the United States

5.2.2 Cases of ACLF by Grades in the United States

5.2.3 Organ failures associated with ACLF in the United States

5.2.4 Potential precipitating events of ACLF in the United States

5.3 Germany

5.3.1 Cases of Acute-on-chronic liver failure (ACLF) in Germany

5.3.2 Cases of ACLF by Grades in Germany

5.3.3 Organ failures associated with ACLF in Germany

5.3.4 Potential precipitating events of ACLF in Germany

5.4 France

5.4.1 Cases of Acute-on-chronic liver failure (ACLF) in France

5.4.2 Cases of ACLF by Grades in France

5.4.3 Organ failures associated with ACLF in France

5.4.4 Potential precipitating events of ACLF in France

5.5 Italy

5.5.1 Cases of Acute-on-chronic liver failure (ACLF) in Italy

5.5.2 Cases of ACLF by Grades in Italy

5.5.3 Organ failures associated with ACLF in Italy

5.5.4 Potential precipitating events of ACLF in Italy

5.6 Spain

5.6.1 Cases of Acute-on-chronic liver failure (ACLF) in Spain

5.6.2 Cases of ACLF by Grades in Spain

5.6.3 Organ failures associated with ACLF in Spain

5.6.4 Potential precipitating events of ACLF in Spain

5.7 United Kingdom

5.7.1 Cases of Acute-on-chronic liver failure (ACLF) in the UK

5.7.2 Cases of ACLF by Grades in the UK

5.7.3 Organ failures associated with ACLF in the UK

5.7.4 Potential precipitating events of ACLF in the UK

5.8 Japan

5.8.1 Cases of Acute-on-chronic liver failure (ACLF) in Japan

5.8.2 Cases of ACLF by Grades in Japan

5.8.3 Organ failures associated with ACLF in Japan

5.8.4 Potential precipitating events of ACLF in Japan

6 Treatment

6.1 Guidelines

6.1.1 APASL

6.1.2 EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

6.2 Case Study

6.2.1 Acute-on-chronic liver failure vs. traditional acute decompensation of cirrhosis

6.3 Patient Journey

7 Appendix

7.1 Report Methodology

8 DelveInsight Capabilities

9 Disclaimer

10 About DelveInsight

List of Tables

Table 1: Summary of ACLF, Epidemiology, and Key Events (2017–2030)

Table 2: Characteristics of the available definitions for acute-on-chronic liver failure (ACLF)

Table 3: CLIF Consortium Organ Failure Score: simplified version of the CLIF-SOFA score

Table 4: Cases of ACLF in the United States (2017–2030)

Table 5: Cases of ACLF by Grades in the United States (2017–2030)

Table 6: Organ failures associated with ACLF in the United States (2017–2030)

Table 7: Potential precipitating events of ACLF in the United States (2017–2030)

Table 8: Cases of ACLF in Germany (2017–2030)

Table 9: Cases of ACLF by Grades in Germany (2017–2030)

Table 10: Organ failures associated with ACLF in Germany (2017–2030)

Table 11: Potential precipitating events of ACLF in Germany (2017–2030)

Table 12: Cases of ACLF in France (2017–2030)

Table 13: Cases of ACLF by Grades in France (2017–2030)

Table 14: Organ failures associated with ACLF in France (2017–2030)

Table 15: Potential precipitating events of ACLF in France (2017–2030)

Table 16: Cases of ACLF in Italy (2017–2030)

Table 17: Cases of ACLF by Grades in Italy (2017–2030)

Table 18: Organ failures associated with ACLF in Italy (2017–2030)

Table 19: Potential precipitating events of ACLF in Italy (2017–2030)

Table 20: Cases of ACLF in Spain (2017–2030)

Table 21: Cases of ACLF by Grades in Spain (2017–2030)

Table 22: Organ failures associated with ACLF in Spain (2017–2030)

Table 23: Potential precipitating events of ACLF in Spain (2017–2030)

Table 24: Cases of ACLF in the UK (2017–2030)

Table 25: Cases of ACLF by Grades in the UK (2017–2030)

Table 26: Organ failures associated with ACLF in the UK (2017–2030)

Table 27: Potential precipitating events of ACLF in the UK (2017–2030)

Table 28: Cases of ACLF in Japan (2017–2030)

Table 29: Cases of ACLF by Grades in Japan (2017–2030)

Table 30: Organ failures associated with ACLF in Japan (2017–2030)

Table 31: Potential precipitating events of ACLF in Japan (2017–2030)

List of Figures

 Figure 1: Proposed unifying pathogenesis for different types of acute-on-chronic liver failure

Figure 2: The clinical course of cirrhosis

Figure 3: Immune dysfunction in ACLF

Figure 4: Pathogenesis of organ failure in ACLF

Figure 5: Cases of ACLF in the United States (2017–2030)

Figure 6: Cases of ACLF by Grades in the United States (2017–2030)

Figure 7: Organ failures associated with ACLF in the United States (2017–2030)

Figure 8: Potential precipitating events of ACLF in the United States (2017–2030)

Figure 9: Cases of ACLF in Germany (2017–2030)

Figure 10: Cases of ACLF by Grades in Germany (2017–2030)

Figure 11: Organ failures associated with ACLF in Germany (2017–2030)

Figure 12: Potential precipitating events of ACLF in Germany (2017–2030)

Figure 13: Cases of ACLF in France (2017–2030)

Figure 14: Cases of ACLF by Grades in France (2017–2030)

Figure 15: Organ failures associated with ACLF in France (2017–2030)

Figure 16: Potential precipitating events of ACLF in France (2017–2030)

Figure 17: Cases of ACLF in Italy (2017–2030)

Figure 18: Cases of ACLF by Grades in Italy (2017–2030)

Figure 19: Organ failures associated with ACLF in Italy (2017–2030)

Figure 20: Potential precipitating events of ACLF in Italy (2017–2030)

Figure 21: Cases of ACLF in Spain (2017–2030)

Figure 22: Cases of ACLF by Grades in Spain (2017–2030)

Figure 23: Organ failures associated with ACLF in Spain (2017–2030)

Figure 24: Potential precipitating events of ACLF in Spain (2017–2030)

Figure 25: Cases of ACLF in the UK (2017–2030)

Figure 26: Cases of ACLF by Grades in the UK (2017–2030)

Figure 27: Organ failures associated with ACLF in the UK (2017–2030)

Figure 28: Potential precipitating events of ACLF in the UK (2017–2030)

Figure 29: Cases of ACLF in Japan (2017–2030)

Figure 30: Cases of ACLF by Grades in Japan (2017–2030)

Figure 31: Organ failures associated with ACLF in Japan (2017–2030)

Figure 32: Potential precipitating events of ACLF in Japan (2017–2030)

Figure 33: Algorithm for management of acute-on-chronic liver failure

Figure 34: Patient Journey for ACLF

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