Chronic Rhinosinusitis Without Nasal Polyps Market

• In 2023, the Chronic Rhinosinusitis Without Nasal Polyps Prevalence was ~71,015 thousand in the 7MM, which is further expected to increase by 2034.
• In 2023, the US accounted for the highest number of Chronic Rhinosinusitis Without Nasal Polyps Diagnosed Prevalent Cases (Chronic Rhinosinusitis Without Nasal Polyps), followed by EU4 and the UK and Japan estimating approximately 42% and 7% cases the 7MM. This trend is likely to be followed during the forecast period as well.
• In Japan, in 2023, ~669 thousand males and ~497 thousand females were affected with Chronic Rhinosinusitis Without Nasal Polyps. DelveInsight estimates that these numbers will increase by 2034.
• In March 2024, the FDA approved XHANCE for the treatment of chronic rhinosinusitis (CRS) without nasal polyps in adults 18 and older. This makes XHANCE the first and only nonsurgical option for treating CRS without nasal polyps.
• The current Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market includes first approved therapy, XHANCE along with other supportive care that provide relief, making up a Chronic Rhinosinusitis Without Nasal Polyps Market Size of nearly USD 3,930 million in the 7MM in 2023. The Chronic Rhinosinusitis Without Nasal Polyps Market Size is expected to increase with an estimated CAGR of 4% attributed to the launch of emerging therapies during the forecast period (2024–2034).
• In September 2023, positive topline results from the BEACON trial showed LYR-220 significantly improved CRS symptoms and SNOT-22 scores, confirming its efficacy and safety in treatment compared to control.
• In May 2024, Lyra announced topline results from the Phase III ENLIGHTEN 1 trial showing that LYR-210 did not meet its primary endpoint of statistically significant improvement compared to sham control in the composite score of the three cardinal symptoms (3CS) of CRS (nasal obstruction, nasal discharge, facial pain/pressure) at 24 weeks. LYR-210 was generally well tolerated, with no product-related serious adverse events.
• The total Chronic Rhinosinusitis Without Nasal Polyps Treatment Market Size is anticipated to experience growth during the forecast period due to the emergence of new and effective treatments, namely, LYR-210 and LYR-220, among others.

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DelveInsight’s “Chronic Rhinosinusitis Without Nasal Polyps Market Insights, Epidemiology, and Market Forecast – 2034” report delivers an in-depth understanding of the Chronic Rhinosinusitis Without Nasal Polyps, historical and forecasted epidemiology as well as the Chronic Rhinosinusitis Without Nasal Polyps Market Trends in the United States, EU4 and the UK (Germany, France, Italy, Spain) and the United Kingdom, and Japan. 

The Chronic Rhinosinusitis Without Nasal Polyps Treatment Market Report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Chronic Rhinosinusitis Without Nasal Polyps Market Size from 2020 to 2034. The Report also covers current Chronic Rhinosinusitis Without Nasal Polyps Treatment Market practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

Chronic Rhinosinusitis Without Nasal Polyps Treatment Market: Understanding and Algorithm

Chronic Rhinosinusitis Without Nasal Polyps is a prevalent and chronic medical condition characterized by inflammation and swelling of the nasal passages and paranasal sinuses, but notably, it does not involve the presence of nasal polyps. 

Individuals with chronic rhinosinusitis without nasal polyps often experience symptoms such as nasal congestion, difficulty breathing through the nose, facial pain or pressure, reduced sense of smell (hyposmia), and a persistent discharge from the nose. These symptoms typically last more than 12 weeks, making it a chronic condition requiring proper management.

 Chronic Rhinosinusitis Without Nasal Polyps Diagnosis

Diagnosing chronic rhinosinusitis without nasal polyps involves a thorough examination of the nasal passages and sinuses by medical professionals, who may also consider the patient’s medical history and the duration of symptoms to differentiate it from other similar conditions. The diagnosis is typically based on specific diagnostic criteria established by medical guidelines. These criteria include two or more of the following major symptoms: nasal blockage/congestion, nasal discharge, facial pain/pressure, and reduced sense of smell. The symptoms of Chronic Rhinosinusitis Without Nasal Polyps must be present for at least 12 consecutive weeks to meet the diagnosis. In some cases, the doctor may order imaging studies, such as a CT scan of the sinuses.

 Further details related to diagnosis are provided in the report…

Chronic Rhinosinusitis Without Nasal Polyps Treatment

Treatment for chronic rhinosinusitis without nasal polyps alleviates inflammation and effectively manages symptoms. Medical management may include the use of nasal corticosteroids to reduce inflammation and antibiotics if there is evidence of a bacterial infection. Nasal irrigations or rinses with saline solutions may also be recommended to help improve nasal health and provide relief. If medical treatment fails to provide sufficient symptom relief or disease control, surgical interventions such as endoscopic sinus surgery (ESS) may be considered. 

Further details related to treatment are provided in the report…

Chronic Rhinosinusitis Without Nasal Polyps Epidemiology

As the market is derived using a patient-based model, the Chronic Rhinosinusitis Without Nasal Polyps epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Prevalent Cases of Chronic Rhinosinusitis (CRS), Total Diagnosed Prevalent Cases of Chronic Rhinosinusitis (CRS), Total Diagnosed Prevalent Cases of Chronic Rhinosinusitis Without Nasal Polyps, and Gender-specific Diagnosed Prevalent Cases of Chronic Rhinosinusitis Without Nasal Polyps in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan, from 2020 to 2034. 

• In the assessment done by DelveInsight, the estimated Chronic Rhinosinusitis Without Nasal Polyps Diagnosed prevalent cases in the 7MM were nearly 17,323 thousand in 2023. 
• DelveInsight's estimates suggests that the number of Chronic Rhinosinusitis Without Nasal Polyps diagnosed prevalent cases in the US reached approximately 11,047 thousand in 2023, accounting for 52% of overall cases in the 7MM.
• The highest Chronic Rhinosinusitis Without Nasal Polyps prevalent cases were accounted by the US in 2023 (~31,563 thousand), which are expected to show a rise in the future.
• Among the European countries, Germany had the highest diagnosed prevalent cases of Chronic Rhinosinusitis Without Nasal Polyps with ~ 2,246 thousand cases, followed by the UK, which had diagnosed prevalent population of ~ 1,410 thousand in 2023. On the other hand, Spain had the lowest diagnosed prevalent population (~983 thousand cases). 
• Based on gender-specific segmentation, females are affected the most by Chronic Rhinosinusitis Without Nasal Polyps in the US, accounting for approximately 5,637 thousand cases in 2023 as compared to ~3,311 thousands in males.

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Chronic Rhinosinusitis Without Nasal Polyps Recent Developments

• Oct 14, 2024 – GSK plc announced positive Phase III results for depemokimab in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). The ANCHOR-1 and ANCHOR-2 trials met their co-primary endpoints, showing significant reductions in nasal polyp score and obstruction after 52 weeks. Adverse event rates were comparable between depemokimab and placebo groups, with full results to be shared at an upcoming scientific congress.

Chronic Rhinosinusitis Without Nasal Polyps Drug Chapters

The drug chapter segment of the Chronic Rhinosinusitis Without Nasal Polyps treatment market report encloses a detailed analysis of Chronic Rhinosinusitis Without Nasal Polyps approved drugs and early-stage (Phase-III and Phase-II) Chronic Rhinosinusitis Without Nasal Polyps Pipeline Drugs. It also helps to understand the Chronic Rhinosinusitis Without Nasal Polyps Clinical Trials details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest Chronic Rhinosinusitis Without Nasal Polyps news and press releases.

Chronic Rhinosinusitis Without Nasal Polyps Marketed Drugs

• XHANCE (fluticasone propionate): Optinose US Inc.

Optinose US Inc.’s first commercial product, XHANCE (fluticasone propionate) nasal spray, 93 μg, is therapeutic, utilizing a proprietary exhalation delivery system (EDS) that delivers a topically-acting corticosteroid for the treatment of chronic rhinosinusitis with nasal polyps and if approved, chronic rhinosinusitis without nasal polyps. In September 2017, the US FDA approved XHANCE for treating nasal polyps in patients aged 18 or older, and it was made widely available through commercial channels in April 2018.  

In March 2024, the FDA broadened the indications for fluticasone propionate (XHANCE) nasal spray to include treatment for chronic rhinosinusitis in adults without nasal polyps. Notably, about two-thirds of individuals with chronic rhinosinusitis, or chronic sinusitis, are without nasal polyps. This milestone marked XHANCE as the first and only treatment option available for Chronic Rhinosinusitis Without Nasal Polyps.

Chronic Rhinosinusitis Without Nasal Polyps Emerging Drugs

• LYR-210: Lyra Therapeutics 

LYR-210 is an implantable anti-inflammatory drug matrix designed to deliver mometasone furoate (MF) locally and consistently to inflamed mucosal tissue for up to 6 months in surgically naïve patients with chronic rhinosinusitis (CRS), both with and without nasal polyps, who have not responded to previous medical treatments. The implant facilitates sustained drug release at challenging nasal inflammation sites without requiring patient compliance, while minimizing systemic side effects typical of oral steroids. 

Administered via a brief, noninvasive office procedure by an ENT specialist using a single-use applicator under endoscopic guidance, LYR-210 is currently undergoing a Phase III program named ENLIGHTEN, which includes two pivotal trials. These trials, ongoing in the US and Europe, are essential for assessing the drug’s efficacy and safety and will support the FDA submission. 

Enrollment in ENLIGHTEN 2, the second pivotal Phase III trial of LYR-210 in CRS, is ongoing; enrollment completion is expected in the second half of 2024. Topline results from ENLIGHTEN 2 are expected in the first half of 2025. Results from the ENLIGHTEN 1 52-week extension study are expected in Q4 2024.

• LYR-220: Lyra Therapeutics 

LYR-220 is aimed at chronic rhinosinusitis (CRS) patients who still need treatment to control symptoms despite having undergone sinus surgery. Like LYR-210, LYR-220 uses mometasone furoate (MF) but features a larger matrix suited for patients with an enlarged nasal cavity post-surgery. 

In September 2023, positive topline results from the BEACON trial  were reported. The drug achieved statistically significant improvements in key symptoms (nasal obstruction, nasal discharge, facial pain/pressure) as early as week 4, with sustained benefits through week 24. Significant enhancements were also seen in SNOT-22 scores and sinus opacification on CT scans. Additionally, LYR-220 showed notable improvement in loss of smell in a subset of patients. The trial met its primary safety endpoint, with no serious adverse events reported. Commonly reported adverse events included sinusitis, nasopharyngitis, bronchitis, and COVID-19.

Note: Detailed emerging therapies assessment will be provided in the final report of Chronic Rhinosinusitis Without Nasal Polyps.

Chronic Rhinosinusitis Without Nasal Polyps Market Outlook

Chronic Rhinosinusitis Without Nasal Polyps has a diverse treatment classification associated with the disease landscape. The primary goal of treatment for chronic rhinosinusitis without nasal polyps is to reduce inflammation, control symptoms, and improve the patient’s quality of life. Antibiotics and corticosteroids are major revenue generators in the current treatment landscape. The use of antibiotics and corticosteroids (intranasal and oral) is guided by clinical practice guidelines, which provide evidence-based recommendations to healthcare professionals to manage Chronic Rhinosinusitis Without Nasal Polyps. 

Chronic rhinosinusitis with sinusitis without nasal polyps (Chronic Rhinosinusitis Without Nasal Polyps) presents a distinct therapeutic challenge due to its prevalence in patients who do not benefit from conventional treatments. Management typically involves a combination of nasal corticosteroids, saline irrigation, and sometimes systemic medications to address inflammation and manage symptoms. The introduction of targeted treatments, such as fluticasone propionate (XHANCE) nasal spray, has marked a significant advancement in the field. XHANCE, recently approved by the FDA for Chronic Rhinosinusitis Without Nasal Polyps, provides localized, sustained delivery of corticosteroids via an exhalation delivery system, specifically designed for patients without nasal polyps. This innovative approach helps reduce inflammation effectively in the nasal cavity while minimizing systemic side effects commonly associated with oral steroids. The development of such targeted therapies represents a crucial step in addressing the unmet needs of Chronic Rhinosinusitis Without Nasal Polyps patients, offering a more tailored and effective treatment option.

• The pharmaceutical landscape continues to evolve with ongoing clinical trials exploring novel treatments, including like LYR-210 and LYR-220, and other drugs. 
• In 2023, the US had the largest Chronic Rhinosinusitis Without Nasal Polyps Market Size among the 7MM, accounting for approximately USD 2,505 million, expected to increase further by 2034.
• Among the EU countries, Germany had the highest Chronic Rhinosinusitis Without Nasal Polyps Market Size with nearly USD 377 million in 2023, while Spain had the lowest Chronic Rhinosinusitis Without Nasal Polyps Market Size with USD ~198 million in 2023.
• The Chronic Rhinosinusitis Without Nasal Polyps Market Size in Japan was estimated to be about USD 212 million in 2023.
• With the expected launch of upcoming therapies, such as LYR-210 and LYR-220, among others, the total Chronic Rhinosinusitis Without Nasal Polyps Market Size is expected to show change in the upcoming years.

Chronic Rhinosinusitis Without Nasal Polyps Drugs Uptake

This section focuses on the uptake rate of potential Chronic Rhinosinusitis Without Nasal Polyps drugs expected to launch in the market during 2020–2034. For example, LYR-210 in the US is expected to be launched by 2025 with a peak share of 12%. LYR-220 is anticipated to take 7 years to peak with a medium-fast uptake.

Further detailed analysis of emerging therapies drug uptake in the report…

Chronic Rhinosinusitis Without Nasal Polyps Pipeline Development Activities

The Chronic Rhinosinusitis Without Nasal Polyps therapeutics market report provides insights into different therapeutic candidates in Phase II and Phase I stage. It also analyzes key Chronic Rhinosinusitis Without Nasal Polyps Companies involved in developing targeted therapeutics. 

Pipeline Development Activities

The Chronic Rhinosinusitis Without Nasal Polyps therapeutics market report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Chronic Rhinosinusitis Without Nasal Polyps emerging therapies. 

KOL Views

To keep up with current market trends, we take KOLs and SMEs’ opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Chronic Rhinosinusitis Without Nasal Polyps evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Department of Surgery, Ralph H. Johnson VA Medical Center; Department of Otorhinolaryngology, Ulm University Medical Center, Frauensteige; Department of Allergy and Medical Rhinology, University College London, London; Department of Pediatrics, Nippon Medical School, Tokyo, and others.

Delveinsight’s analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Chronic Rhinosinusitis Without Nasal Polyps market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the Chronic Rhinosinusitis Without Nasal Polyps therapeutics market and the unmet needs.

Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market: Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst’s discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

Further, the therapies’ safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided. 

Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market Access and Reimbursement

The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment. The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market Report Scope

• The Chronic Rhinosinusitis Without Nasal Polyps therapeutics market report covers a segment of key events, an executive summary, descriptive overview, explaining its causes, signs and symptoms, and currently available therapies.
• Comprehensive insight has been provided into the Chronic Rhinosinusitis Without Nasal Polyps Epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression, and treatment guidelines.
• Additionally, an all-inclusive account of the current and emerging therapies and the elaborative profiles of late-stage and prominent therapies will impact the current treatment landscape.
• A detailed review of the Chronic Rhinosinusitis Without Nasal Polyps treatment market, historical and forecasted Chronic Rhinosinusitis Without Nasal Polyps market size, Chronic Rhinosinusitis Without Nasal Polyps drugs market share by therapies, detailed assumptions, and rationale behind the approach is included in the report covering the 7MM drug outreach.
• The Chronic Rhinosinusitis Without Nasal Polyps therapeutics market report provides an edge while developing business strategies, by understanding trends, through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help shape and drive the 7MM Chronic Rhinosinusitis Without Nasal Polyps drugs market.

Chronic Rhinosinusitis Without Nasal Polyps Report Insights

• Patient-based Chronic Rhinosinusitis Without Nasal Polyps Market Forecastng
• Therapeutic Approaches
• Chronic Rhinosinusitis Without Nasal Polyps Pipeline Drugs Analysis
• Chronic Rhinosinusitis Without Nasal Polyps Market Size and Trends
• Existing and Future Chronic Rhinosinusitis Without Nasal Polyps Drugs Market Opportunity 

Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market Report Key Strengths

• 11 years Chronic Rhinosinusitis Without Nasal Polyps Market Forecast
• The 7MM Coverage 
• Chronic Rhinosinusitis Without Nasal Polyps Epidemiology Segmentation
• Key Cross Competition 
• Conjoint Analysis
• Chronic Rhinosinusitis Without Nasal Polyps Drugs Uptake
• Key Chronic Rhinosinusitis Without Nasal Polyps Market Forecast Assumptions

Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market Report Assessment

• Current Chronic Rhinosinusitis Without Nasal Polyps Treatment Market Practices
• Chronic Rhinosinusitis Without Nasal Polyps Unmet Needs
• Chronic Rhinosinusitis Without Nasal Polyps Pipeline Drugs Profiles
• Chronic Rhinosinusitis Without Nasal Polyps Drugs Market Attractiveness
• Qualitative Analysis (SWOT and Conjoint Analysis)

Key Questions

Chronic Rhinosinusitis Without Nasal Polyps Treatment Market Insights

• What was the Chronic Rhinosinusitis Without Nasal Polyps drugs market share (%) distribution in 2020 and how it would look like in 2034?
• What would be the Chronic Rhinosinusitis Without Nasal Polyps market size as well as market size by therapies across the 7MM during the forecast period (2024–2034)?
• What are the key findings pertaining to the market across the 7MM and which country will have the largest Chronic Rhinosinusitis Without Nasal Polyps market size during the forecast period (2024–2034)?
• At what CAGR, the Chronic Rhinosinusitis Without Nasal Polyps drugs market is expected to grow at the 7MM level during the forecast period (2024–2034)?
• What would be the Chronic Rhinosinusitis Without Nasal Polyps market outlook across the 7MM during the forecast period (2024–2034)?
• What would be the Chronic Rhinosinusitis Without Nasal Polyps market growth till 2034 and what will be the resultant market size in the year 2034?
• How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Chronic Rhinosinusitis Without Nasal Polyps Epidemiology Insights

• What is the disease risk, burden, and Chronic Rhinosinusitis Without Nasal Polyps Unmet Needs?
• What is the historical Chronic Rhinosinusitis Without Nasal Polyps patient population in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
• What would be the forecasted patient population of Chronic Rhinosinusitis Without Nasal Polyps at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Chronic Rhinosinusitis Without Nasal Polyps?
• Out of the above-mentioned countries, which country would have the highest prevalent population of Chronic Rhinosinusitis Without Nasal Polyps during the forecast period (2024–2034)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2024–2034)?

Current Chronic Rhinosinusitis Without Nasal Polyps Treatment Market Scenario, Marketed Drugs, and Emerging Therapies

• What are the current options for the Chronic Rhinosinusitis Without Nasal Polyps Treatment along with the approved therapy?
• What are the current treatment guidelines for the treatment of Chronic Rhinosinusitis Without Nasal Polyps in the US, Europe, And Japan?
• What are the Chronic Rhinosinusitis Without Nasal Polyps marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, and efficacy, etc.?
• How many Chronic Rhinosinusitis Without Nasal Polyps Companies are developing therapies for the treatment?
• How many emerging therapies are in the mid-stage and late stages of development for the treatment of Chronic Rhinosinusitis Without Nasal Polyps?
• What are the key collaborations (Industry–Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Chronic Rhinosinusitis Without Nasal Polyps therapies? 
• What are the recent therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies? 
• What are the clinical studies going on for Chronic Rhinosinusitis Without Nasal Polyps and their status?
• What are the key designations that have been granted for the emerging therapies for Chronic Rhinosinusitis Without Nasal Polyps?
• What are the 7MM historical and forecasted Chronic Rhinosinusitis Without Nasal Polyps Drugs Market? 

Reasons to Buy

• The Chronic Rhinosinusitis Without Nasal Polyps Therapeutics Market report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Chronic Rhinosinusitis Without Nasal Polyps Drugs Market.
• Insights on patient burden/disease Chronic Rhinosinusitis Without Nasal Polyps Prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the existing Chronic Rhinosinusitis Without Nasal Polyps Drugs Market opportunity in varying geographies and the growth potential over the coming years.
• Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
• Identification of strong upcoming players in the Chronic Rhinosinusitis Without Nasal Polyps Drugs Market will help in devising strategies that will help in getting ahead of competitors.
• Detailed analysis and potential of current and emerging therapies under the conjoint analysis section to provide visibility around leading emerging drugs.
• Highlights of Access and Reimbursement policies of approved therapies, barriers to accessibility of off-label expensive therapies, and patient assistance programs.
• To understand the perspective of Key Opinion Leaders around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in future.
• Detailed insights on the unmet need of the existing Chronic Rhinosinusitis Without Nasal Polyps Drugs Market so that the upcoming players can strengthen their development and launch strategy.

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