chronic sialorrhea epidemiology forecast

Key Highlights

• Chronic sialorrhea is a condition characterized by excessive drooling, often associated with neurological and neuromuscular disorders such as Parkinson’s disease, cerebral palsy, schizophrenia, Amyotrophic Lateral Sclerosis (ALS), multiple sclerosis and stroke.
• Despite its prevalence, it remains underdiagnosed and poorly understood, leading to a lack of comprehensive data on patient demographics, clinical characteristics, and treatment patterns.
• Although commonly seen in neurologically impaired individuals across various age groups, chronic sialorrhea can also occur independently. It can substantially diminish quality of life, causing perioral skin damage, speech difficulties, and social stigma, and in neurologically impaired patients, it further heightens the risk of dysphagia and aspiration pneumonia, posing serious clinical concerns.
• Chronic sialorrhea patients were predominantly aged 65 or older, and male. In children, the most common cause is cerebral palsy, affecting 10–38% of this population, whereas in adults, Parkinson's disease is the primary etiology with prevalence rates as high as 70–80%.
• In the 7MM, total diagnosed prevalent cases of chronic sialorrhea were approximately 3,244,150 in 2024. These numbers are expected to increase in the forecast period 2025–2034.
• In Japan, among the age-specific cases 10% were found to be children, while 90% adult were affected by chronic sialorrhea.
• In EU4 and the UK, Germany had the highest number of diagnosed prevalent cases of chronic sialorrhea in 2024.

DelveInsight’s “Chronic Sialorrhea – Epidemiology Forecast – 2034” report delivers an in-depth understanding of chronic sialorrhea, historical and forecasted epidemiology of chronic sialorrhea in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

Geography Covered

• The United States
• EU4 (Germany, France, Italy, and Spain) and the United Kingdom
• Japan

Study Period: 2020–2034

Chronic Sialorrhea Understanding

Chronic Sialorrhea Overview

Chronic sialorrhea, also known as hypersalivation and excessive drooling, is a debilitating condition characterized by the involuntary accumulation and overflow of saliva from the mouth. Unlike acute sialorrhea, which may result from temporary factors, chronic forms persist over months or years. This condition affects individuals across age groups but is particularly prevalent in pediatric populations with developmental disorders and in adults with neurodegenerative diseases. It not only causes physical discomfort but also significantly impacts social interactions, nutritional intake, and overall quality of life. Chronic sialorrhea can be classified as anterior and posterior sialorrhea based on direction of saliva flow.

The symptoms of chronic sialorrhea include visible saliva loss onto the lips, chin, and clothing, often causing perioral dermatitis, difficulty in speaking and eating, halitosis (bad breath), dehydration, fatigue of the jaw muscles, coughing, gagging, and choking.

Further details  are provided in the report…

Chronic Sialorrhea Diagnosis

The diagnosis of chronic sialorrhea includes a detailed clinical history focused on onset, duration, triggers, medications, and comorbid neurological or systemic conditions. This is followed by a targeted physical examination to assess oral health, dental alignment, tongue function, and any signs of infection or motor deficits. Further, it is complemented by a systematic workup including laboratory tests, imaging tests,  salivary flow measurement (sialometry), Drooling Severity and Frequency Scale (DSFS), drooling quotient, teacher drooling scale, and Flexible Endoscopic Evaluation of Swallowing (FEES) to identify underlying causes and rule out mimicking conditions, which often requires input from otolaryngology, neurology, or dental specialists.

Further details related to diagnosis are provided in the report…

Chronic Sialorrhea: Epidemiology

The chronic sialorrhea epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by diagnosed prevalent cases of sialorrhea associated etiologies, prevalent cases of sialorrhea, and gender-specific cases of chronic sialorrhea in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2020 to 2034.

• Throughout the 7MM, the US accounted for the maximum prevalent cases of chronic sialorrhea with about 1,447,300 cases.
• Among EU4 and the UK, Parkinson's disease were found to be more affected by chronic sialorrhea than stroke.
• Germany accounted for about 16% chronic sialorrhea diagnosed prevalent cases in 2024.
• Japan accounted for about 366,700 cases of chronic sialorrhea cases in 2024.

Scope of the Report

• The report covers a segment of key events, an executive summary, a descriptive overview of chronic sialorrhea, explaining its causes, signs and symptoms, pathogenesis, and diagnostic approaches.
• Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression.
• A detailed review of the chronic sialorrhea epidemiology, detailed assumptions, and rationale behind our approach is included in the report.
• A detailed review of current challenges in establishing the diagnosis.

Chronic Sialorrhea Report Insights

• Patient population
• Patient population by age
• Country-wise epidemiology distribution

Chronic Sialorrhea Report key Strengths

• 10 years forecast
• The 7MM coverage
• Chronic sialorrhea epidemiology segmentation

Chronic Sialorrhea Report Assessment

• Epidemiology segmentation
• Current diagnostic practices

FAQs

• What are the disease risks and burdens of chronic sialorrhea epidemiology? What will be the growth opportunities across the 7MM with respect to the patient population about chronic sialorrhea epidemiology?
• What is the historical and forecasted chronic sialorrhea epidemiology patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
• How often is chronic sialorrhea misdiagnosed or diagnosed late due to overlapping symptoms?
• What are the current gaps in epidemiological reporting, such as under-recognition or lack of standardized diagnostic criteria?

Reasons to Buy

• Insights on patient burden/disease prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand key opinion leaders’ perspectives on the diagnostic challenges to overcome barriers in the future.
• Detailed insights into various factors hampering disease diagnosis and other existing diagnostic challenges.