cluster headache epidemiology forecast insight

DelveInsight’s ‘Cluster Headache (CH) – Epidemiology Forecast – 2034’ report delivers an in-depth understanding of and historical and forecasted epidemiology of Cluster Headache in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Geographies Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Cluster Headache Disease Understanding

According to the National Organization of Rare Diseases (NORD), Cluster headaches (CHs) are an uncommon, severe form of primary neurovascular headaches. CH is the most painful form of headaches, with the pain occurring on one side of the head and behind or above the eye or at the temple most commonly.

CH is subcategorized into episodic and chronic forms based on certain factors like duration, frequency, periodicity, etc. In episodic cluster headache (ECH), at least two cluster periods lasting 7 days to 1 year, separated by pain-free periods lasting 1 month or more, are seen. In chronic cluster headache (CCH), attacks occur for more than 1 year without remission or with remission lasting less than 1 month.

As reported in a recent report by Diana Yi-Ting Wei et al. (2018) in the article titled “Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis” gives the low prevalence of cluster headache compared to migraine, it is difficult to assess the prevalence of cluster headache in the community accurately. Nonetheless, the author suggests that, given the specific features of cluster headache, the community can be identified using questionnaires based on the ICHD criteria. The study identified seven subjects with cluster headaches, corresponding to a prevalence of 381 per 100,000. Since August 2007, there have been two further population-based studies, one from the Republic of Georgia with a prevalence of 87 per 100,000 and in rural Ethiopia with a prevalence of 1.3%. Cluster headache has been historically considered to have a male preponderance, with a high male-to-female ratio, and is thought to be different between episodic cluster headache (ECH) and chronic cluster headache (CCH). In a study involving 545 patients with ECH and CCH examined between 1963 and 1997, it was observed that there was a downward trend in male preponderance over this period. However, there is still an overall male preponderance for cluster headache.

In another report titled “The incidence and prevalence of cluster headache: a meta-analysis of population-based studies” written by Fischera et al. (2008), the pooled data showed a lifetime prevalence of 124 per 100,000 and a 1-year prevalence of 53 per 100,000. The ratio of episodic vs. chronic cluster headache was 6.0. This analysis revealed a relatively stable lifetime prevalence, which suggests that about one in 1000 people suffers from cluster headache, the prevalence being independent of the region of the population study. The sex ratio (male to female) is higher than published in several patient-based epidemiological studies.

Cluster Headache Epidemiology

The CH epidemiology division provides insights about the historical and current patient pool, along with the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends and assumptions undertaken.

Key Findings

The total prevalent cases of Cluster Headache patients are increasing in the 7MM during the study period, i.e., 2021-2034.

The disease epidemiology covered in the report provides historical as well as forecasted Cluster Headache symptoms epidemiology segmented as the prevalence of Cluster Headache, diagnosed cases of Cluster Headache, type-specific cases of Cluster Headache, gender-specific cases of Cluster Headache, and age-specific cases of Cluster Headache. The report includes the prevalent scenario of Cluster Headache symptoms in 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2021 to 2034.

Country-wise Cluster Headache Epidemiology

The epidemiology segment also provides the Cluster Headache epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

The total prevalent cases of Cluster Headache associated in 7MM countries were 877,859 in 2020.

• As per the estimates, the United States has the largest prevalent population of Cluster Headache.
• Among the EU5 countries, Germany had the highest prevalent cases of Cluster Headache, followed by France. On the other hand, Spain had the lowest prevalent cases, with 61,798 cases in 2020.

Scope of the Report

• The Cluster Headache report covers a detailed overview explaining its causes, symptoms, and classification, pathophysiology, diagnosis, and treatment patterns.
• The Cluster Headache epidemiology report and model provide an overview of Cluster Headache’s risk factors and global trends in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan).
• The report provides insight into Cluster Headache’s historical and forecasted patient pool in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan.
• The report helps to recognize the growth opportunities in the 7MM concerning the patient population.
• The report assesses the disease risk and burden and highlights the unmet needs of Cluster Headache.
• The report provides the Cluster Headache epidemiology segmentation by prevalent cases of Cluster Headache in the 7MM.
• The report provides the Cluster Headache epidemiology segmentation by diagnosed cases of Cluster Headache in 7MM.
• The report provides the Cluster Headache epidemiology segmentation by type-specific cases of Cluster Headache in 7MM.
• The report provides the Cluster Headache epidemiology segmentation by gender-specific prevalent cases of Cluster Headache in 7MM.
• The report provides the Cluster Headache epidemiology segmentation by age-specific prevalent cases of Cluster Headache in 7MM.

Report Highlights

• 10-year Forecast of Cluster Headache epidemiology
• 7MM Coverage
• Prevalent Cases of Cluster Headache
• Diagnosed Cases of Cluster Headache
• Prevalent Cases according to segmentation: Type-specific cases of Cluster Headache
• Prevalent Cases according to segmentation: Gender-specific cases of Cluster Headache
• Prevalent Cases according to segmentation: Age-specific cases of Cluster Headache

KOL Views

We interview KOLs, and SMEs’ opinions through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered

• What will be the growth opportunities in the 7MM for the patient population about Cluster Headache?
• What are the key findings of the Cluster Headache epidemiology across 7MM, and which country will have the highest number of patients during the study period (2021-2034)?
• What would be the total number of Cluster Headache patients across the 7MM during the study period (2021-2034)?
• Among the EU5 countries, which country will have the highest number of patients during the study period (2021-2034)?
• At what CAGR the patient population is expected to grow by 7MM during the study period (2021-2034)?
• What are the disease risk, burdens, and unmet needs of Cluster Headache?
• What are the currently available treatments for Cluster Headache?

Reasons to buy

The Cluster Headache epidemiology report will allow the user to:

• Develop business strategies by understanding the trends shaping and driving the global Cluster Headache market.
• Quantify patient populations in the global Cluster Headache market to improve product design, pricing, and launch plans.
• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Cluster Headache therapeutics in each of the markets covered.
• Understand the magnitude of the Cluster Headache population by its total prevalent cases.
• Understand the magnitude of the Cluster Headache population by its diagnosed cases.
• Understand the magnitude of the Cluster Headache population by its type-specific cases.
• Understand the magnitude of the Cluster Headache population by its gender-specific cases.
• Understand the magnitude of the Cluster Headache population by its age-specific cases.
• The Cluster Headache epidemiology report and model were written and developed by masters and Ph.D. level epidemiologists.
• The Cluster Headache epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over a 10-year forecast period using reputable sources.

Key Assessments

• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population