critical limb ischemia epidemiology forecast insight

DelveInsight’s 'Critical Limb Ischemia (CLI)- Epidemiology Forecast–2034’ report delivers an in-depth understanding of the Critical Limb Ischemia (CLI), historical and forecasted epidemiology as well as the Critical Limb Ischemia (CLI) trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Geographies Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Critical Limb Ischemia (CLI) Disease Understanding

Critical limb ischemia (CLI) is a clinical syndrome of ischemic pain at rest and ischemic tissue loss such as non-healing ulcers or gangrene, related to Peripheral artery disease (PAD) of the lower limbs. CLI is the end stage of PAD, and the macrovascular lesions induce a reduction of distal perfusion. Nutrient blood flow to the tissues and microcirculation exchange is severely altered in this condition.

The term “Critical limb ischemia” (CLI) is outdated and fails to encompass the full spectrum of patients who are evaluated and treated for limb-threatening ischemia in modern practice. Instead, the new term “Chronic limb-threatening ischemia” (CLTI) is proposed to include a broader and more heterogeneous group of patients with varying degrees of ischemia that can often delay wound healing and increase amputation risk.

The Rutherford categorization has classically defined CLI as rest pain (class 4), tissue loss (class 5), and/or gangrene (class 6). Alternatively, the Fontaine classification labels rest pain as class 3 and tissue loss or gangrene as class 4.

Critical Limb Ischemia (CLI) Diagnosis

Ischemic rest pain usually affects the forefoot, is frequently worse at night, and often requires opiate analgesia for management. If present for >2 weeks and combined with hemodynamic evidence of severely impaired perfusion (e.g., absolute AP <50 mm Hg, absolute TP <30 mm Hg), it is diagnostic of Critical Limb Ischemia (CLI).

Continued in the report…..

Critical Limb Ischemia (CLI) Epidemiology Perspective by DelveInsight

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Cases of CLI, Age-specific Diagnosed prevalent Cases of CLI, Severity-specific Diagnosed Prevalent Cases of CLI, and Diagnosed Prevalent Cases of No-option CLI in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2021 to 2034.

Critical Limb Ischemia (CLI) Detailed Epidemiology Segmentation

• The total diagnosed prevalent population of CLI in seven major markets (7MM) was 2,053,158 cases in 2020.
• The total diagnosed prevalent cases of CLI in the US, in 2020 was 1,073,553.
• In 2020, there were 869,822 diagnosed prevalent cases of CLI in EU-5.
• In the Epidemiology model of DelveInsight, we have considered six age groups for the estimation of total critical limb ischemia patient’s population i.e. 40-49 years, 50-59 years, 60-69 years, 70-79 years, 80-84 years, and ≥85 years
• In 2020, the highest cases of critical limb ischemia were estimated among the population of age group 80-84 years (256,959) followed by 60-69 years (247,975) in the US.
• As per the DelveInsight analysis, the total diagnosed prevalent cases of CLI in Japan were 109,783 in 2020.

Scope of the Report

• The report covers the descriptive overview of Critical Limb Ischemia (CLI), explaining its symptoms, grading, pathophysiology, and various diagnostic approaches.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
• The report assesses the disease risk and burden of Critical Limb Ischemia (CLI).
• The report helps to recognize the growth opportunities in the 7MM with respect to the patient population.

Report Highlights

• 10-Year Forecast of Critical Limb Ischemia (CLI)
• 7MM Coverage
• Total Diagnosed Prevalent Cases of CLI
• Age-specific Diagnosed prevalent Cases of CLI
• Severity-specific Diagnosed Prevalent Cases of CLI
• Diagnosed Prevalent Cases of No-option CLI

Key Questions Answered

• What are the disease risk and burden of Critical Limb Ischemia (CLI)?
• What is the historical Critical Limb Ischemia (CLI) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
• What would be the forecasted patient pool of Critical Limb Ischemia (CLI) at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Critical Limb Ischemia (CLI)?
• Out of the above-mentioned countries, which country would have the highest prevalent population of Critical Limb Ischemia (CLI) during the forecast period (2025-2034)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2025-2034)?

Reasons to buy

The Critical Limb Ischemia (CLI) report will allow the user to -

• Develop business strategies by understanding the trends shaping and driving the 7MM Critical Limb Ischemia (CLI) epidemiology forecast.
• The Critical Limb Ischemia (CLI) epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The Critical Limb Ischemia (CLI) epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the 10-year forecast period using reputable sources.

Key Assessments

• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population