cystinosis epidemiology forecast insight

DelveInsight’s ‘Cystinosis—Epidemiology Forecast–2034’ report delivers an in-depth understanding of the Cystinosis, historical and forecasted epidemiology as well as the Cystinosis trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

Geographies Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Cystinosis Disease Understanding

Cystinosis is a rare autosomal recessive metabolic disorder in which cystinosin gene (CTNS) mutations result in defective cystine transport across the lysosomal membrane and accumulation and crystallization (disulfide-linked dimers of the amino acid cysteine) in all tissues with progressive and widespread functional impairment of kidneys, thyroid, testis, pancreas, muscle, brain, and eye. In the eye, cystine crystal formation and accumulation in the cornea leads to photophobia, blepharospasm, corneal erosions, superficial punctate keratopathy, and band keratopathy. Without treatment, this can result in a complete loss of vision requiring keratoplasty.

Cystinosis is a condition in which the body accumulates the amino acid cystine (a building block of proteins) within cells. Excess cystine forms crystals that can build up and damage cells. These crystals negatively affect many systems in the body, especially the kidneys and eyes. There are three distinct types of cystinosis. In order of decreasing severity, they are nephropathic cystinosis (Infantile Nephropathic), intermediate cystinosis (Late Onset or juvenile cystinosis), and non-nephropathic or ocular cystinosis.

Continued in the report…..

Cystinosis Epidemiology Perspective by DelveInsight

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Prevalence of Cystinosis, Diagnosed Prevalence of Cystinosis and Type-specific Diagnosed Prevalence of Cystinosis scenario in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2021 to 2034.

Cystinosis Detailed Epidemiology Segmentation

• Total prevalent cases of cystinosis in the 7MM were found to be 3,008 in 2020, which might increase in 2034. These prevalent cases are expected to increase during the study period (2021-2034).
• The total diagnosed prevalent cases of cystinosis in 7MM are anticipated to reach 1,472 in 2034.
• Among 7MM, the United States has the highest diagnosed prevalent cases of cystinosis with 655 cases in 2020. In EU-5, the UK has the highest number of cases, i.e., 222, followed by Germany with 183 cases. While Italy has the least number of cases with 43 in 2020.
• In 2020, there was a total of 599 cases of Infantile nephropathic cystinosis, 33 cases of Juvenile nephropathic cystinosis, and 23 cases of Adult-onset (Ocular, or non-nephropathic cystinosis) in the US. These cases are expected to increase by 2034.
• Japan had 23 diagnosed prevalent cases of cystinosis in 2020. These cases are expected to decrease. Out of the total diagnosed cases, 21 cases account for infantile nephropathic cystinosis, 1 case of Juvenile nephropathic cystinosis, and 1 case of Adult-onset in 2020.

Scope of the Report

• The report covers the descriptive overview of Cystinosis, explaining its causes, symptoms, pathophysiology, and genetic basis.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
• The report assesses the disease risk and burden and highlights the unmet needs of Cystinosis.
• The report helps to recognize the growth opportunities in the 7MM concerning the patient population.
• The report provides the segmentation of the disease epidemiology for 7MM by Prevalence of Cystinosis, Diagnosed Prevalence of Cystinosis, and Type-specific Diagnosed Prevalence of Cystinosis.

Report Highlights

• 10-Year Forecast of Cystinosis
• 7MM Coverage
• Prevalence of Cystinosis
• Diagnosed Prevalence of Cystinosis
• Type-specific Diagnosed Prevalence of Cystinosis

Key Questions Answered

• What are the disease risk, and burdens of Cystinosis?
• What is the historical Cystinosis patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
• What would be the forecasted patient pool of Cystinosis at the 7MM level?
• What will be the growth opportunities across the 7MM for the patient population about Cystinosis?
• Out of the above-mentioned countries, which country would have the highest prevalent population of Cystinosis during the forecast period (2025-2034)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2025-2034)?

Reasons to buy

The Cystinosis report will allow the user to -

• Develop business strategies by understanding the trends shaping and driving the 7MM Cystinosis epidemiology forecast.
• The Cystinosis epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The Cystinosis epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the 10-year forecast period using reputable sources.

Key Assessments

• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population