Idiopathic Membranous Nephropathy Epidemiology

Key Highlights

• Idiopathic Membranous Nephropathy (IMN) is a significant type of glomerular disease characterized by the presence of large amounts of protein in the urine (nephrotic syndrome) and is primarily an autoimmune condition.
• The total prevalent population of IMN in the 7MM is estimated to be ~71,000 cases in 2023.
• In 2023, the US accounted for ~40% of all prevalent cases of IMN in the 7MM, while EU4 and the UK combined accounted for ~35%, and Japan contributed ~25%. This data highlights Japan as the second-largest contributor after US to IMN cases.
• Among the EU4 and the UK, approximately 16,000 treated cases of Idiopathic Membranous Nephropathy (IMN) were reported in 2023.

Report Summary

• The report offers extensive knowledge regarding the epidemiology segments and predictions, presenting a deep understanding of the potential future growth in diagnosis rates, disease progression, and diagnostic guidelines. It provides comprehensive insights into these aspects, enabling a thorough assessment of the subject matter.
• The report also encompasses a comprehensive analysis of Idiopathic Membranous Nephropathy, providing an in-depth examination of its historical and projected data from 2021 to 2034. It includes detailed assumptions and the underlying rationale for the methodology.
• The report also encompasses a comprehensive analysis of Idiopathic Membranous Nephropathy, providing an in-depth examination of its historical and projected data from 2021 to 2034. It includes detailed assumptions and the underlying rationale for the methodology.
• The report includes qualitative insights that provide an edge in understanding trends through SWOT analysis and expert insights/KOL views, including experts from various hospitals and prominent universities, patient journey that help shape and drive the Idiopathic Membranous Nephropathy landscape.

The table given below further depicts the key segments provided in the report:

Idiopathic Membranous Nephropathy Disease Understanding 

Idiopathic Membranous Nephropathy Overview, and Diagnosis

Idiopathic Membranous Nephropathy (IMN) is a prevalent form of glomerular disease primarily associated with nephrotic syndrome. It is characterized by the immune system's attack on the glomeruli, leading to significant proteinuria, edema, and potential progression to renal failure. The condition is termed "idiopathic" when no identifiable secondary cause is found, although it can also arise from various underlying conditions, including autoimmune diseases and infections. IMN typically affects adults, particularly middle-aged men, and presents with symptoms such as frothy urine, swelling in the legs and abdomen, and weight gain due to fluid retention.

The diagnosis of IMN involves a combination of clinical evaluation and laboratory tests. Initial assessments typically include urine analysis to detect proteinuria, which is often in the nephrotic range (>3.5 g/day). Blood tests are conducted to evaluate kidney function and check for hypoalbuminemia and dyslipidemia, common in nephrotic syndrome. A definitive diagnosis is usually confirmed through a kidney biopsy, which reveals characteristic changes in the glomeruli, such as immune complex deposition along the capillary walls. Additionally, serological tests for specific antibodies, such as those against the phospholipase A2 receptor (PLA2R), can help differentiate primary IMN from secondary forms, guiding further management strategies.

Further details related to country-based variations in diagnosis are provided in the report

Idiopathic Membranous Nephropathy Epidemiology

The Idiopathic Membranous Nephropathy (IMN) epidemiology chapter in the report provides historical as well as forecasted in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan from 2024 to 2034. The Idiopathic Membranous Nephropathy (IMN) epidemiology is segmented with detailed insights into total prevalent cases, antigen-specific cases, total treated cases of Idiopathic Membranous Nephropathy (IMN).

• In 2023, the US accounted for ~40% of all prevalent cases of IMN in 7MM.
• Japan's data suggests a relatively stable trend in the prevalence of IMN over the forecasted period of 2024-2034.
• Germany had the highest prevalence of IMN among EU4 and the UK, accounting for ~30% of cases, followed by the UK with ~20%, in 2023.
• In the 7MM, PLA2R-specific cases contributed approximately 75% among the antigen-specific cases in 2023.

KOL Views

To stay abreast of the latest trends we conduct primary research by seeking the opinions of Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) who work in the relevant field. This helps us fill any gaps in data and validate our secondary research.

Our team of analysts at Delveinsight connected with more than 15 KOLs across the 7MM. We contacted institutions. By obtaining the opinions of these experts, we gained a better understanding of the current epidemiology patterns in the Idiopathic Membranous Nephropathy landscape, which will assist our clients in analyzing the overall epidemiology scenario.

Idiopathic Membranous Nephropathy Report Insights

• Patient Population
• Idiopathic Membranous Nephropathy Epidemiology Segmentation
• Existing Epidemiological Trends and Predictions

Idiopathic Membranous Nephropathy Report Key Strengths

• Eleven-year Forecast
• The 7MM Coverage 
• Idiopathic Membranous Nephropathy Epidemiology Segmentation

Idiopathic Membranous Nephropathy Report Assessment

• Epidemiological Trends and Disease Progression
• Qualitative Analysis (SWOT, Expert Insights, Unmet Needs)

Key Questions

• Would there be any changes observed in the epidemiological trends of Idiopathic Membranous Nephropathy?
• Will there be improvements in the understanding of Idiopathic Membranous Nephropathy progression?
• Would research advances lead to better epidemiological data for Idiopathic Membranous Nephropathy?
• How will the diagnostic testing space impact the epidemiology of Idiopathic Membranous Nephropathy?
• How will the prevalence and incidence of Idiopathic Membranous Nephropathy evolve in the coming years?

Reasons to buy

• Insights on disease burden, details regarding diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the change in Idiopathic Membranous Nephropathy cases in varying geographies over the coming years.
• A detailed overview of total prevalent cases, antigen-specific cases, total treated cases of Idiopathic Membranous Nephropathy is included.
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the treatment-eligible patient pool.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.