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Open Angle Glaucoma Pipeline Insight

DelveInsight’s, “Open-Angle Glaucoma - Pipeline Insight, 2021,” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Open-Angle Glaucoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Open-Angle Glaucoma Understanding

Open-Angle Glaucoma: Overview

Glaucoma is an eye disease that gradually steals vision. Open-Angle Glaucoma is the most common type of glaucoma. Open-Angle Glaucoma is a chronic, progressive, and irreversible multifactorial optic neuropathy that is characterized by an open angle of the anterior chamber, optic nerve head changes, progressive loss of peripheral vision, followed by central visual field loss. Glaucoma affects 70 million people worldwide and is the second leading cause of blindness. The underlying pathology of Open-Angle Glaucoma lies in the apoptosis of retinal ganglion cells. Open-Angle Glaucoma can be clinically evaluated using a variety of diagnostic tools including optic disc changes, visual field changes, and elevated intraocular pressure. The goal of treatment of Open-Angle Glaucoma is to prevent the progression of optic nerve head changes and also the prevention of deterioration of visual field.


"Open-Angle Glaucoma - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Open-Angle Glaucoma pipeline landscape is provided which includes the disease overview and Open-Angle Glaucoma treatment guidelines. The assessment part of the report embraces, in depth Open-Angle Glaucoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Open-Angle Glaucoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Open-Angle Glaucoma R&D. The therapies under development are focused on novel approaches to treat/improve Open-Angle Glaucoma.

Open-Angle Glaucoma Emerging Drugs Chapters

This segment of the Open-Angle Glaucoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.


Open-Angle Glaucoma Emerging Drugs


QLS-101: Qlaris Bio

QLS-101 is a novel topical ocular therapy that lowers intraocular pressure. QLS-101 modulates KATP channel by relaxing vessels of the vascular and vascular-like tissues distal to the Trabecular Meshwork, thereby reducing distal outflow resistance and lowering Episcleral Venous Pressure (EVP). Qlaris Bio has initiated clinical studies with QLS-101 in patients with Primary Open Angle Glaucoma, Ocular Hypertension, Normal Tension Glaucoma, and Sturge-Weber syndrome.


Razuprotafib: Aerpio Pharmaceuticals

Razuprotafib is a novel small molecule Tie2 activator that enhances endothelial function and stabilizes blood vessels, including pulmonary and renal vasculature. Razuprotafib (AKB-9778) topical drops is currently under Phase II clinical evaluation for treatment of primary open angle glaucoma (POAG).

Further product details are provided in the report……..

Open-Angle Glaucoma: Therapeutic Assessment

This segment of the report provides insights about the different Open-Angle Glaucoma drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in Open-Angle Glaucoma

There are approx. 20+ key companies which are developing the therapies for Open-Angle Glaucoma. The companies which have their Open-Angle Glaucoma drug candidates in the most advanced stage, i.e. Phase III include, Ocular Therapeutix.

Phases

DelveInsight’s report covers around 20+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Open-Angle Glaucoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • Intravitreal
  • Subretinal
  • Topical
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Open-Angle Glaucoma: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Open-Angle Glaucoma therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Open-Angle Glaucoma drugs.

Open-Angle Glaucoma Report Insights

  • Open-Angle Glaucoma Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Open-Angle Glaucoma Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Open-Angle Glaucoma drugs?
  • How many Open-Angle Glaucoma drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Open-Angle Glaucoma?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Open-Angle Glaucoma therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Open-Angle Glaucoma and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Open-Angle Glaucoma: Overview

  • Causes
  • Mechanism of Action 
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type 

Open-Angle Glaucoma – DelveInsight’s Analytical Perspective

In-depth Commercial Assessment

  • Open-Angle Glaucoma companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Open-Angle Glaucoma Collaboration Deals

  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)

  • Comparative Analysis

Travoprost ophthalmic: Ocular Therapeutix

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

QLS-101: Qlaris Bio

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Early Stage Products (Phase I/II) 

  • Comparative Analysis

PA5108: PolyActiva

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Preclinical and Discovery Stage Products

  • Comparative Analysis

NB 1111: Skye Bioscience

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Open-Angle Glaucoma Key Companies

Open-Angle Glaucoma Key Products

Open-Angle Glaucoma- Unmet Needs

Open-Angle Glaucoma- Market Drivers and Barriers

Open-Angle Glaucoma- Future Perspectives and Conclusion

Open-Angle Glaucoma Analyst Views

Open-Angle Glaucoma Key Companies

Appendix

List of Table

Table 1: Total Products for Open-Angle Glaucoma

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Open-Angle Glaucoma

Figure 2: Late Stage Products

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products    

• Qlaris Bio

• Ocular Therapeutix

• SALVAT

• Aerpio Pharmaceuticals

• Ocularis Pharma

• PolyActiva

• AbbVie

• Annexon

• Skye Bioscience

• GrayBug

• Quark Pharmaceuticals

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