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Persistent Epithelial Defect - Epidemiology forecast- 2034

Published Date : 2025

Pages : 75

Region : United States, Japan, EU4 & UK

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persistent epithelial defect epidemiology forecast insight

DelveInsight’s ‘Persistent Epithelial Defect–Epidemiology Forecast—2034’ report delivers an in-depth understanding of the Persistent Epithelial Defect, historical and forecasted epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Geography Covered

The United States
EU5 (Germany, France, Italy, Spain, and the United Kingdom)
Japan

Study Period: 2021-2034

Persistent Epithelial Defect Disease Understanding

Persistent Corneal Epithelial Defects, also known as persistent corneal epithelial defects (PEDs or PCEDs), results from the failure of rapid re-epithelialization and closure within 10–14 days after a corneal injury, even with standard supportive treatment. The cornea is the transparent, outermost layer of the eye that uniformly refracts the majority of the light that enters the eye onto the lens and is essential for ideal vision. The corneal surface is composed of five or six layers of epithelial cells.

Healthy corneal epithelium is integral in preventing corneal infections and protecting the damage to the deeper corneal tissue. It is several layers thick and acts as a barrier via tightly linked cells through hemidesmosomes and gap junctions. The surface integrity alongside the corneal transparency is very important in maintaining the corneal refractive role in vision.

The high turnover of the epithelial cells helps heal minor corneal abrasions and acute epithelial defects uneventfully within 7–14 days. The multi-layered corneal epithelium acts as a protective barrier to infectious agents via tight junctions between neighboring cells, and it maintains its smooth optical surface by constantly regenerating cells in the basal cell layer. Disruptions in this protective layer can render the eye susceptible to infection, stromal ulceration, perforation, scarring, and decreased visual acuity. PEDs commonly extend into the stromal layer, causing stromal melting, secondary ulceration, and stromal scarring. Also, an insult to the cornea resulting in an acute epithelial defect is a lesion that usually heals over the 7–14 days’ time frame. In contrast, a persistent epithelial defect is unable to close within this normal interval.

Persistent Epithelial Defect Epidemiology

The Persistent Epithelial Defect epidemiology division provides insights about the historical and current patient pool along with the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

The disease epidemiology covered in the report provides historical as well as forecasted Persistent Epithelial Defect epidemiology segmented as the Total Incident Cases of Persistent Epithelial Defect, Gender-specific incidence of Persistent Epithelial Defect, Etiology-specific incidence of Persistent Epithelial Defect. The report includes the Incident scenario of Persistent Epithelial Defect in 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2021 to 2034.

Country Wise- Persistent Epithelial Defect Epidemiology

The epidemiology segment also provides the Persistent Epithelial Defect epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

The total incident population of Persistent Epithelial Defect Associated in 7MM countries was estimated to be 241,452 cases in 2020 and expected to increase for the study period, i.e., 2021-2034.
As per the estimates, United States has the highest incident population of Persistent Epithelial Defect in 7MM.
Among the EU5 countries, Germany had the highest incident population of Persistent Epithelial Defect. On the other hand, Spain had the lowest number of cases, 14,547 cases in 2020.

Scope of the Report

Persistent Epithelial Defect report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis, and treatment patterns
Persistent Epithelial Defect Epidemiology Report and Model provide an overview of the risk factors and global trends of Persistent Epithelial Defect in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan)
The report provides insight into the historical and forecasted patient pool of Persistent Epithelial Defect in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan
The report helps recognize the growth opportunities in the 7MM concerning the patient population
The report assesses the disease risk and burden and highlights the unmet needs of Persistent Epithelial Defect
The report provides the segmentation of the Persistent Epithelial Defect epidemiology by incident Cases of Persistent Epithelial Defect in 7MM
The report provides the segmentation of the Persistent Epithelial Defect epidemiology by incidence of Persistent Epithelial Defect, Total Incident Cases of Persistent Epithelial Defect, Severity-specific incidence of Persistent Epithelial Defect, Incident Cases of Persistent Epithelial Defect Based on risk Factors in 7MM

Report Highlights

10-year Forecast of Persistent Epithelial Defect epidemiology
7MM Coverage
Total Incident Cases of Persistent Epithelial Defect
Severity-specific incidence of Persistent Epithelial Defect
Incident Cases of Persistent Epithelial Defect Based on risk Factors

KOL Views

We interview KOLs, and SME’s opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered

What will be the growth opportunities in the 7MM concerning the patient population about Persistent Epithelial Defect?
What are the key findings of Persistent Epithelial Defect epidemiology across 7MM, and which country will have the highest number of patients during the forecast period (2025-2034)?
What would be the total number of patients with Persistent Epithelial Defect across the 7MM during the forecast period (2025-2034)?
Among the EU5 countries, which country will have the highest number of patients during the forecast period (2025-2034)?
At what CAGR the patient population is expected to grow by 7MM during the forecast period (2025-2034)?
What are the disease risk, burden, and unmet needs of Persistent Epithelial Defect?
What are the currently available treatments for Persistent Epithelial Defect?

Reasons to buy

The Persistent Epithelial Defect Epidemiology report will allow the user to -

Develop business strategies by understanding the trends shaping and driving the global Persistent Epithelial Defect market
Quantify patient populations in the global Persistent Epithelial Defect market to improve product design, pricing, and launch plans
Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Persistent Epithelial Defect therapeutics in each of the markets covered
Understand the magnitude of Persistent Epithelial Defect population by its incident cases
Understand the magnitude of Persistent Epithelial Defect population by its risk factors cases
The Persistent Epithelial Defect epidemiology report and model was written and developed by Masters and PhD level epidemiologists
The Persistent Epithelial Defect Epidemiology Model developed by DelveInsight is easy to navigate, interactive with dashboPED, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over a 10-year forecast period using reputable sources

Key Assessments

Patient Segmentation
Disease Risk and Burden
Risk of disease by the segmentation
Factors driving growth in a specific patient population

1. Key Insights

2. Report Introduction

3. Persistent Corneal Epithelial Defects Market Overview at a Glance

3.1. Market Share (%) Distribution of Persistent Corneal Epithelial Defects in 2018

3.2. Market Share (%) Distribution of Persistent Corneal Epithelial Defects in 2030

4. Executive Summary of Persistent Corneal Epithelial Defects

5. Organizations contributing towards Persistent Epithelial Defect

6. Disease Backgroung and Overview

6.1. Introduction

6.2. Etiology

6.3. Clinical Presentation

6.4. Pathophysiology

6.5. Diagnosis

6.5.1. Differential diagnosis

7. Unmet Needs

8. Epidemiology and Patient Population

8.1. Key Findings

8.2. 7MM Total Incident Patient Population of Persistent Corneal Epithelial Defects

8.3. Assumption and Rationale

8.4. The United States

8.4.1. Incident Cases of Persistent Corneal Epithelial Defects in the United States

8.4.2. Incident cases of PED based on Gender in the United States

8.4.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United States

8.5. EU5

8.6. Germany

8.6.1. Incident Cases of Persistent Corneal Epithelial Defects in Germany

8.6.2. Incident cases of PED based on Gender in Germany

8.6.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Germany

8.7. France

8.7.1. Incident Cases of Persistent Corneal Epithelial Defects in France

8.7.2. Incident cases of PED based on gender in France

8.7.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in France

8.8. Italy

8.8.1. Incident Cases of Persistent Corneal Epithelial Defects in Italy

8.8.2. Incident cases of PED based on Gender in Italy

8.8.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Italy

8.9. Spain

8.9.1. Incident Cases of Persistent Corneal Epithelial Defects in Spain

8.9.2. Incident cases of PED based on Gender in Spain

8.9.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Spain

8.10. United Kingdom

8.10.1. Incident Cases of Persistent Corneal Epithelial Defects in the United Kingdom

8.10.2. Incident cases of PED based on Gender in the United Kingdom

8.10.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United Kingdom

8.11. Japan

8.11.1. Incident Cases of Persistent Corneal Epithelial Defects in Japan

8.11.2. Incident cases of PED based on Gender in Japan

8.11.3. Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Japan

9. Market Drivers

10. Market Barriers

11. KOL Views

12. SWOT Analysis

13. Appendix

13.1. Bibliography

13.2. Report Methodology

14. DelveInsight Capabilities

15. Disclaimer

16. About DelveInsight

List of Tables:

List of Table

Table 1: Summary of Persistent Corneal Epithelial Defects, Market, Epidemiology, and Key Events (2018–2030)

Table 2: Organizations contributing towards Persistent Epithelial Defect (PED)

Table 3: Diagnosed Incident Patient Population of Persistent Corneal Epithelial Defects in 7MM (2018–2030)

Table 4: Incident Cases of Persistent Corneal Epithelial Defects in the United States (2018–2030)

Table 5: Incident cases of PED based on Gender in the United States (2018–2030)

Table 6: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United States (2018–2030)

Table 7: Prevalent Cases of Persistent Corneal Epithelial Defects in Germany (2018–2030)

Table 8: Incident cases of PED based on Gender in Germany (2018–2030)

Table 9: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Germany (2018–2030)

Table 10: Incident Cases of Persistent Corneal Epithelial Defects in France (2018–2030)

Table 11: Incident cases of PED based on Gender in France (2018–2030)

Table 12: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in France (2018–2030)

Table 13: Incident Cases of Persistent Corneal Epithelial Defects in Italy (2018–2030)

Table 14: Incident cases of PED based on Gender in Italy (2018–2030)

Table 15: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Italy (2018–2030)

Table 16: Incident Cases of Persistent Corneal Epithelial Defects in Spain (2018–2030)

Table 17: Incident cases of PED based on Gender in Spain (2018–2030)

Table 18: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Spain (2018–2030)

Table 19: Incident Cases of Persistent Corneal Epithelial Defects in the United Kingdom (2018–2030)

Table 20: Incident cases of PED based on Gender in the United Kingdom (2018–2030)

Table 21: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United Kingdom (2018–2030)

Table 22: Prevalent Cases of Persistent Corneal Epithelial Defects in Japan (2018–2030)

Table 23: Incident cases of PED based on Gender in Japan (2018–2030)

Table 24: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Japan (2018–2030)

List of Figures:

List of Figures

Figure 1: Depiction of a Persistent Epithelial Defect (PED)

Figure 2: Incident Patient Population of Persistent Corneal Epithelial Defects in 7MM (2018–2030)

Figure 3: Incident Cases of Persistent Corneal Epithelial Defects in the United States (2018–2030)

Figure 4: Incident cases of PED based on Gender in the US (2018–2030)

Figure 5: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United States (2018–2030)

Figure 6: Incident Cases of Persistent Corneal Epithelial Defects in Germany (2018–2030)

Figure 7: Incident cases of PED based on mutation in Germany (2018–2030)

Figure 8: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Germany (2018–2030)

Figure 9: Incident Cases of Persistent Corneal Epithelial Defects in Germany (2018–2030)

Figure 10: Incident cases of PED based on Gender in France (2018–2030))

Figure 11: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in France (2018–2030)

Figure 12: Incident Cases of Persistent Corneal Epithelial Defects in Italy (2018–2030)

Figure 13: Incident cases of PED based on Gender in Italy (2018–2030)

Figure 14: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Italy (2018–2030)

Figure 15: Incident Cases of Persistent Corneal Epithelial Defects in Spain (2018–2030)

Figure 16: Incident cases of PED based on Gender in Spain (2018–2030)

Figure 17: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Spain (2018–2030)

Figure 18: Incident Cases of Persistent Corneal Epithelial Defects in the United Kingdom (2018–2030)

Figure 19: Incident cases of PED based on Gender in the United Kingdom (2018–2030)

Figure 20: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in the United Kingdom (2018–2030)

Figure 21: Incident Cases of Persistent Corneal Epithelial Defects in Japan (2018–2030)

Figure 22: Incident cases of PED based on Gender in Japan (2018–2030)

Figure 23: Etiology-specific Incidence of Persistent Corneal Epithelial Defects in Japan (2018–2030)

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