Post-Bariatric Hypoglycemia Epidemiology

Key Highlights

• Bariatric surgery, or weight loss surgery, is a group of surgical procedures aimed at aiding individuals with severe obesity achieve significant and sustained weight reduction. These surgeries are typically recommended for individuals unsuccessful in achieving weight loss through nonsurgical methods, such as diet and exercise, and who have obesity-related health conditions.
• Postbariatric hypoglycemia is the development of hypoglycemia (low blood sugar) following bariatric surgery, such as gastric bypass or sleeve gastrectomy. It typically occurs within a few years after surgery.
• Diagnosis of postbariatric hypoglycemia involves a combination of clinical evaluation, medical history review, blood glucose monitoring, and ruling out other potential causes of hypoglycemia. Additional tests such as mixed meal tolerance tests, continuous glucose monitoring, and pancreatic imaging may be utilized to aid in diagnosis.
• Regarding the epidemiology of postbariatric hypoglycemia, in 2022, it was found that the United States accounted for ~79% of the total cases of postbariatric hypoglycemia in the 7MM.
• Among the EU4 countries, the least number of cases of PBH were found in Spain, i.e., ~1,400 cases in the year 2022. These cases are expected to increase by 2034.
• Currently, there exists a lack of widely accepted diagnostic criteria specifically tailored for postbariatric hypoglycemia. The absence of standardized criteria makes it difficult to compare research findings, establish epidemiology rates, and develop consistent treatment approaches.

The table given below further depicts the key segments provided in the report:

Report Summary

The report offers extensive knowledge regarding the epidemiology segments and predictions, presenting a deep understanding of the potential future growth in diagnosis rates, disease progression, and treatment guidelines. It provides comprehensive insights into these aspects, enabling a thorough assessment of the subject matter.

Postbariatric Hypoglycemia Disease Understanding and Treatment

Postbariatric Hypoglycemia overview

Postbariatric hypoglycemia is the development of hypoglycemia (low blood sugar) following bariatric surgery, such as gastric bypass or sleeve gastrectomy. It typically occurs within a few years after surgery. Several risk factors contribute to postbariatric hypoglycemia, including rapid weight loss, altered gastrointestinal anatomy, increased insulin sensitivity, hyperinsulinemia, and reactive hypoglycemia. Common symptoms of postbariatric hypoglycemia include weakness, sweating, palpitations, anxiety, confusion, lightheadedness, and in severe cases, loss of consciousness or seizures. These symptoms typically occur in the fasting state or after meals.

Postbariatric Hypoglycemia diagnosis

Currently, a lack of widely accepted diagnostic criteria specifically tailored for postbariatric hypoglycemia gives rise to challenges in accurately identifying and diagnosing the condition. Diagnosis of postbariatric hypoglycemia involves a combination of clinical evaluation, medical history review, blood glucose monitoring, and ruling out other potential causes of hypoglycemia. Additional tests such as mixed meal tolerance tests, continuous glucose monitoring, and pancreatic imaging may be utilized to aid in diagnosis. Given the challenges in diagnosing postbariatric hypoglycemia, conducting a thorough clinical evaluation is important. Further, research and collaboration are required to develop diagnostic criteria for postbariatric hypoglycemia.

Further details related to country-based variations are provided in the report…

Postbariatric Hypoglycemia Epidemiology

The Postbariatric Hypoglycemia epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Type-Specific Bariatric Surgery Cases, Total Postbariatric Hypoglycemia (PBH) Cases, Postbariatric Hypoglycemia (PBH) Cases in different types of Bariatric Surgeries, Severity-specific Postbariatric Hypoglycemia (PBH) Cases, and Total Treated Cases of Postbariatric Hypoglycemia (PBH) in the 7MM covering the United States, EU4 countries (Germany, France, Italy, Spain) and the United Kingdom, and Japan from 2021 to 2034.

• In 2022, the total postbariatric hypoglycemia (PBH) cases in the United States were ~82,000, projected to increase during the forecast period (2025-2034).
• The total postbariatric hypoglycemia (PBH) cases in EU4 and the UK were ~21,000 in 2022. The cases will increase during the forecast period (2025-2034).
• The total number of postbariatric hypoglycemia (PBH) cases in Japan were ~200 in 2022.

Postbariatric Hypoglycemia (PBH) Report Insights

• Postbariatric Hypoglycemia (PBH) Patient Population
• Type-specific and severity-specific distribution in Postbariatric Hypoglycemia (PBH)
• Country-wise Epidemiology Distribution

Postbariatric Hypoglycemia Report Key Strengths

• Ten-year Forecast
• The 7MM Coverage
• Postbariatric Hypoglycemia Epidemiology Segmentation

Postbariatric Hypoglycemia Report Assessment

• Epidemiology Segmentation
• Current Diagnostic Practices

Key Questions

Epidemiology Insights

• What are the disease risks, burdens, and unmet needs of Postbariatric Hypoglycemia (PBH)? What will be the growth opportunities across the 7MM with respect to the patient population of Postbariatric Hypoglycemia (PBH)?
• What is the historical and forecasted Postbariatric Hypoglycemia (PBH) patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
• Which type is the largest contributor to the Postbariatric Hypoglycemia (PBH) patient pool?
• Which severity has the most number of cases of Postbariatric Hypoglycemia (PBH) in the 7MM?
• Reasons to Buy
• Insights on disease burden, details regarding diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the change in Postbariatric Hypoglycemia (PBH) cases in varying geographies over the coming years.
• Detailed overview on type-specific, severity-specific, and treated cases of Postbariatric Hypoglycemia (PBH) is included.
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the treatment-eligible patient pool.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.