sepsis epidemiology forecast insight

DelveInsight’s ‘Sepsis—Epidemiology Forecast–2034’ report delivers an in-depth understanding of the Sepsis , historical and forecasted epidemiology as well as the Sepsis trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Geography Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2021-2034

Sepsis Disease Understanding

As per the Sepsis Alliance, Sepsis is the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death.

In the past, septicemia, blood poisoning, and other vague terminology, meaning different things to different people, were used frequently, hampering attempts to identify septic patients properly. In 1991, a consensus conference developed definitions of Sepsis that linked infection with a systemic inflammatory response—the systemic inflammatory response syndrome (SIRS)—which was defined using simple clinical and laboratory parameters. Although Sepsis detection was challenging, the definition of SIRS was rather unspecific since similar inflammatory responses were seen as part of the physiological response to noninfectious insults, such as surgery and pancreatitis. Besides, the SIRS criteria performed poorly in identifying patients who required critical care and who had significant morbidity and mortality.

These issues led to a recent new consensus definition for Sepsis and Septic shock. This international task force defined Sepsis as ‘life-threatening organ dysfunction caused by a dysregulated host response to infection.’ The United States has not adopted these definitions since they have not been tested prospectively. All of the research and improvement in mortality has been based on utilization of the SEP-2 definitions that have been used since 1992 (in all of the clinical research as well as in clinical practice) and its associated screening and early management bundles. One of the greatest concerns is that waiting till the organ dysfunction before intervening makes it harder to treat and more likely to have poor outcomes.

Continued in the report…..

Sepsis Epidemiology Perspective by DelveInsight

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Incident Cases of Sepsis, Gender-Specific Incident Cases of Sepsis, Severity-Specific Incident Cases of Sepsis, Origin-Specific Incident Cases of Sepsis scenario in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2021 to 2034.

Sepsis Detailed Epidemiology Segmentation

• In 2020, the total estimated Incident Cases of Sepsis were 3,400,940 cases in the 7MM, which is expected to increase in the forecast period.
• US is the major contributor (55.01%, in 2020) to the incident population of Sepsis in the 7MM, with 1,870,897 cases.
• Out of EU5 countries, Germany had the highest incident cases in 2020 followed by the UK and Spain. France accounted for the least number of cases in 2020.
• Assessments indicate that lung infection, UTI infection, gut infection, and skin infection are the leading four infection sites in patients with Sepsis, accounting for 35%, 25%, 11%, and 11% of all sites of infection, respectively in the United States in 2020. In 2020, there were 654,814, 467,724, 205,799, and 205,799 Sepsis cases due to lung infection followed by UTI, gut infection, and skin infection in the US.
• In 2020, there were 1,066,411 cases of Sepsis without organ dysfunction followed by severe Sepsis and septic shock, accounting for 18.4% and 24.6% of the total cases respectively in the US.

“From several epidemiology studies, it was observed that the disease is more common in males as compared to females, but this trend is opposite in the US. In EU, and Japan, 50–65% of sepsis cases are contributed by males, and 35–50% of the cases are contributed by females. But in the US, around 49% of the cases are of males, and 51% are of females. Additionally, There are several infections that lead to sepsis, but it has been seen that lung infection, UTI infection, gut infection, and skin infection were the leading four infection sites in patients with sepsis.”

Scope of the Report

• The report covers the descriptive overview of Sepsis, explaining its causes, symptoms, pathophysiology, and genetic basis.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
• The report assesses the disease risk and burden and highlights the unmet needs of Sepsis.
• The report helps to recognize the growth opportunities in the 7MM with respect to the patient population.
• The report provides the segmentation of the disease epidemiology for 7MM by Total Incident Cases of Sepsis, Gender-specific Incident Cases of Sepsis, Severity-specific Incident Cases of Sepsis, Origin-specific Incident Cases of Sepsis.

Report Highlights

• 10-Year Forecast of Sepsis
• 7MM Coverage
• Total Incident Cases of Sepsis
• Male and Female Cases of Sepsis
• Sepsis Patients among different age groups

Key Questions Answered

• What are the disease risk, and burden of Sepsis ?
• What is the historical Sepsis patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
• What would be the forecasted patient pool of Sepsis at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Sepsis ?
• Out of the above-mentioned countries, which country would have the highest incident population of Sepsis during the forecast period (2025-2034)?
• At what CAGR the population is expected to grow across the 7MM during the forecast period (2025-2034)?

Reasons to buy

The Sepsis report will allow the user to -

• Develop business strategies by understanding the trends shaping and driving the 7MM Sepsis epidemiology forecast.
• The Sepsis epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The Sepsis epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the 10-year forecast period using reputable sources.

Key Assessments

• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population