Uncomplicated Urinary Tract Infection Epidemiology

Key Highlights

• Urinary tract infection (UTI) is the most common bacterial infection caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus saprophyticus.
• Uncomplicated UTI (uUTI) typically affects individuals who are otherwise healthy and have no structural or neurological urinary tract abnormalities. Complicated UTI is associated with factors that compromise the urinary tract or host defense.
• Symptoms of uUTI vary depending on the extent of the infection. Lower UTIs mainly involve the urethra, and bladder, and tend to present with localized symptoms such as strong and frequent urge to urinate, cloudy, bloody, or strong-smelling urine, pain, or a burning sensation when urinating. uUTI extending to the ureter or kidneys (i.e., pyelonephritis) often involves more systemic signs and symptoms, such as leukocytosis, fever, chills, abdominal pain, flank pain, and nausea/vomiting.
• The gold standard for UTI diagnosis is the urine examination, including quantitative urine culture and its assessment, with appropriate clinical examinations and typical symptom assessment. A negative test for nitrite/leukocytes may be considered to rule out UTI with sufficient certainty in patients with a low pretest probability. The detection of blood, leukocytes, and nitrite independently increases the likelihood of the presence of a UTI. The combination of the positive findings further increases the possibility of the diagnosis.
• The differential diagnosis for UTI includes consideration of other types of non-bacterial infection and the causes of recurrent UTI. 
• In the 7MM, the United States accounted for the highest number of Occurrence-specific cases of Uncomplicated Urinary Tract Infection in 2023.
• In 2023, the age group of 30–49 years accounted for the majority of cases, contributing to 35% of all cases across the 7MM.
• France and the UK had the highest occurrence-specific Cases of uUTI among the EU4 and the UK, each accounting for more than 20% of cases in 2023.

Report Summary

• The report offers extensive knowledge regarding the epidemiology segments and predictions, presenting a deep understanding of the potential future growth in diagnosis rates, disease progression, and diagnostic guidelines. It provides comprehensive insights into these aspects, enabling a thorough assessment of the subject matter.
• The report also encompasses a comprehensive analysis of uUTI, providing an in-depth examination of its historical and projected data from 2021 to 2034. It includes detailed assumptions and the underlying rationale for the methodology.
• The report also encompasses a comprehensive analysis of uUTI, providing an in-depth examination of its historical and projected data from 2021 to 2034. It includes detailed assumptions and the underlying rationale for the methodology.
• The report includes qualitative insights that provide an edge in understanding trends through SWOT analysis and expert insights/KOL views, including experts from various hospitals and prominent universities, and patient journeys that help shape and drive the uUTI landscape.

The table given below further depicts the key segments provided in the report:

Uncomplicated Urinary Tract Infection Disease Understanding 

Uncomplicated Urinary Tract Infection Overview, and Diagnosis

Urinary tract infection (UTI) is caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus saprophyticus. A UTI can develop in any part of the urinary tract, including the urethra, bladder, ureters, or kidneys. A UTI (also known as a bladder infection) is a common condition that occurs when bacteria migrate into the usually sterile urinary tract and multiply. Bladder infections are common, especially among women. Research suggests that at least 40–60% of women develop a UTI during their lifetime, and most of these infections are bladder infections. One in four women is likely to have a repeat infection. UTI is classified as either complicated or uncomplicated. 

Diagnostic methods are designed to detect the presence of UTI, but also, when appropriate, to ascertain the etiology (bacterial spectrum) that triggered the infection and how it can be treated (susceptibility to antibiotics). The gold standard for UTI diagnosis is the urine examination, including quantitative urine culture and its assessment, with appropriate clinical examinations and typical symptom assessment. A negative test for nitrite/leukocytes may be considered to rule out UTI with sufficient certainty in patients with a low pretest probability. The detection of blood, leukocytes, and nitrite independently increases the likelihood of the presence of a UTI. The combination of the positive findings further increases the likelihood of the diagnosis.

Further details related to country-based variations are provided in the report…

Uncomplicated Urinary Tract Infection Epidemiology

The Uncomplicated Urinary Tract Infection epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total Occurrence-specific Cases, total Diagnosed Cases, Age group-specific Cases, Pathogen-specific Cases, and total Treated Cases of Uncomplicated Urinary Tract Infection in the United States, EU4 countries (Germany, France, Italy, Spain) and the United Kingdom, and Japan from 2021 to 2034. 

• The total Occurrence-specific cases of Uncomplicated Urinary Tract Infection in the US were around 15,300,000 cases in 2023.
• In the United States, the highest number of age-specific cases were recorded for 30–49 years of age, i.e., ~3,300,000 cases in 2023. Followed by the age group of 18–29 years and 50–69 years and the least cases were recorded in the≥70 years age group.
• France and the UK had the highest occurrence-specific cases of uUTI among the EU4 and the UK, each accounting for more than 20% of cases in 2023.
• Uropathogenic Escherichia Coli (UPEC) was responsible for the majority of uUTI cases, accounting for 75% of them.
• In 2023, the total treated cases of uncomplicated urinary tract infection in the US were ~9,000,000 for the first-line treated patients.

Further details related to epidemiology will be provided in the report…

KOL Views

To stay abreast of the latest trends we conduct primary research by seeking the opinions of Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) who work in the relevant field. This helps us fill any gaps in data and validate our secondary research.

Our team of analysts at Delveinsight connected with more than 15 KOLs across the 7MM. We contacted institutions. By obtaining the opinions of these experts, we gained a better understanding of the current epidemiology patterns in the uUTI landscape, which will assist our clients in analyzing the overall epidemiology scenario.

Uncomplicated Urinary Tract Infection Report Insights

• Patient Population
• Uncomplicated Urinary Tract Infection  Epidemiology Segmentation
• Existing Epidemiological Trends and Predictions

Uncomplicated Urinary Tract Infection Report Key Strengths

• Eleven-year Forecast
• The 7MM Coverage 
• Uncomplicated Urinary Tract Infection Epidemiology Segmentation

Uncomplicated Urinary Tract Infection Report Assessment

• Epidemiological Trends and Disease Progression
• Qualitative Analysis (SWOT, Expert Insights, Unmet Needs)

Key Questions

• Would there be any changes observed in the epidemiological trends of uUTI?
• Will there be improvements in the understanding of uUTI progression?
• Would research advances lead to better epidemiological data for uUTI?
• How will the diagnostic testing space impact the epidemiology of uUTI?
• How will the prevalence and incidence of uUTI evolve in the coming years?

Reasons to buy

• Insights on disease burden, details regarding diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the change in uUTI cases in varying geographies over the coming years.
• A detailed overview of diagnosed incident cases, diagnosed incident cases of uveal melanoma by subtype, mutation type-specific cases, age-specific cases, stage-specific cases, and treated cases are included.
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the treatment-eligible patient pool.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.