31May

Another MET inhibitor expected to make their way in METex14+ mutated NSCLC

Phase II study of savolitinib in patients (pts) with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping mutations (METex14+)


Abstract No : 9519

Abstract Type : Poster Discussion Session

Indication : METex14+ PSC and other NSCLC

Intervention : Savolitinib

Company : Hutchison MediPharma Limited

Technology : Small molecule


Results:

As of October 31, 2019, 593 pts were pre-screened/screened, 87 identified with METex14+ and 70 treated. Among treated pts, median age was 68.7 years (range 51.7-85.0), 58.6% pts were male, 92.9% stage IV, 60.0% previously treated, 57.1% with adenocarcinoma, 35.7% with PSC and the rest with other pathological types. Sixty-one pts were efficacy evaluable by IRC assessment (N = 61) (including pts who had at least one measurable lesion at baseline and had $1 scheduled post-baseline tumor assessment or evidence of any post-baseline radiological disease progression): ORR was 47.5% (95% CI: 34.6%, 60.7%), disease control rate 93.4% (95% CI: 84.1%, 98.2%) and median duration of response not reached yet. The median progression-free survival was 6.8 months (95% CI 4.2, 13.8) among all treated pts. Efficacy results were consistent with investigators’assessments. The most common ($20%) treatment-related adverse events (TRAEs) were peripheral edema, nausea, increased AST/ ALT, vomiting and hypoalbuminemia. The incidence of $ grade 3 TRAEs was 41.4%. TRAEs leading to treatment discontinuation occurred in 14.3% pts, among which liver injury and hypersensitivity were most common (each 2.9%).


Conclusion:

Savolitinib demonstrated promising anti-tumor activity and acceptable tolerability in METex14+ NSCLC pts.


Commentary:

Another MET inhibitor (Savolitinib) has shown promising activity in patients (pts) with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping mutations (METex14+)


Refer to Non Small Cell Lung Cancer Market report for detailed Insights.