Arteriosclerosis Obliterans Epidemiology

• Arteriosclerosis obliterans is also known as Peripheral Artery Disease is a chronic occlusive disease where plaque buildup hardens and narrows the arteries, restricting blood flow to the lower extremities.
• PAD is a narrowing or blockage of peripheral arteries that reduces blood flow from the heart and brain to other parts of the body, most commonly affecting the lower extremities, including the legs and feet.
• PAD affects an estimated 236 million individuals globally, representing a significant and growing cardiovascular disease burden.
• Despite its high prevalence, PAD remains substantially underdiagnosed, with studies suggesting that approximately 40–60% of patients are not identified in primary care settings, largely due to its asymptomatic or atypical clinical presentation.
• Lower extremity arteriosclerosis obliterans (LEASO) represents the most common clinical manifestation of PAD, characterized by progressive atherosclerotic narrowing of lower limb arteries and serving as the primary driver of morbidity, including claudication and limb-threatening ischemia.

Arteriosclerosis Obliterans Epidemiology Forecast in the 7MM

DelveInsight's ‘Arteriosclerosis Obliterans Epidemiology Forecast–2036’ report delivers an in-depth understanding of the Arteriosclerosis obliterans, historical and forecasted epidemiology, in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

Arteriosclerosis Obliterans Understanding

Arteriosclerosis Obliterans Overview

Arteriosclerosis obliterans is a chronic, progressive atherosclerotic vascular disorder characterized by the narrowing or occlusion of peripheral arteries, most commonly in the lower limbs. It represents the primary clinical manifestation of PAD and leads to reduced blood flow, resulting in symptoms ranging from asymptomatic disease to intermittent claudication and, in advanced stages, chronic limb-threatening ischemia (CLTI). Arteriosclerosis obliterans is strongly associated with systemic atherosclerosis and significantly increases the risk of cardiovascular events such as myocardial infarction and stroke, with major risk factors including smoking, diabetes, hypertension, dyslipidemia, and advanced age.

Further details are provided in the report.

Arteriosclerosis Obliterans Diagnosis

Diagnosis of arteriosclerosis obliterans is based on clinical evaluation supported by non-invasive vascular testing and imaging modalities. Key clinical features include exertional leg pain (intermittent claudication), rest pain, reduced peripheral pulses, and in severe cases, non-healing ulcers or gangrene. The ankle-brachial index (ABI) is the first-line diagnostic tool, with values ≤0.90 indicating PAD/arteriosclerosis obliterans. Imaging techniques such as duplex ultrasound, CT angiography, MR angiography, and digital subtraction angiography are used to confirm disease severity and guide treatment decisions, while functional assessments like treadmill testing help evaluate disease impact on mobility and quality of life.

Further details are provided in the report. 

Arteriosclerosis Obliterans Epidemiology

Key Findings from Arteriosclerosis Obliterans Epidemiological Analysis and Forecast 

• Arteriosclerosis obliterans is responsible for 95% of chronic occlusive arterial disease, most commonly affects patients over age 50, and affects men more than women 
• The disease shows a strong age-related pattern, with the highest prevalence observed in the 60–74 years age group, reflecting cumulative exposure to cardiovascular risk factors such as smoking, diabetes, and hypertension.
• Males exhibit higher PAD-related mortality before the age of 75 years, while females show comparatively higher mortality rates after 75 years, likely influenced by later disease recognition and greater longevity.

Scope of the Arteriosclerosis Obliterans Epidemiology Report

• The Arteriosclerosis Obliterans epidemiology report covers a segment of a descriptive overview of Arteriosclerosis Obliterans, explaining their causes, signs and symptoms, and pathogenesis.
• Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression.

Arteriosclerosis Obliterans Epidemiology Report Insights

• Arteriosclerosis Obliterans Patient Population Forecast

Arteriosclerosis Obliterans Epidemiology Report Key Strengths

• Epidemiology‑based (Epi‑based) Bottom‑up Forecasting
• 11-year Forecast
• Patient Burden Trends (by geography)

Key Questions Answered in the Arteriosclerosis Obliterans Epidemiology Report

• What are the disease risks, burdens, and unmet needs of Arteriosclerosis obliterans?
• What will be the growth opportunities across the 7MM concerning the patient population with Arteriosclerosis obliterans?
• What is the historical and forecasted Arteriosclerosis obliterans patient pool in the US, EU4 (Germany, France, Italy, and Spain), the UK, and Japan?

Reasons to Buy the Arteriosclerosis Obliterans Epidemiology Report

• Insights on patient burden/disease Arteriosclerosis Obliterans prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand key opinion leaders’ perspectives around the diagnostic challenges to overcome barriers in the future.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.

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