Chronic Myeloid Leukemia Pipeline Insight

DelveInsight’s, “Chronic Myeloid Leukaemia- Pipeline Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Chronic Myeloid Leukaemia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.  

Geography Covered

  • Global coverage

Chronic Myeloid Leukaemia Understanding

Chronic Myeloid Leukaemia: Overview

Chronic myeloid leukaemia (CML) is a type of cancer that affects the white blood cells and tends to progress slowly over many years. It can occur at any age, but is most common in older adults around 60-65 years of age. In CML, the spongy material inside some bones (bone marrow) produces too many myeloid cells – immature white blood cells that are not fully developed and do not work properly. CML does not usually cause any symptoms in its early stages and may only be picked up during tests carried out for another reason. As the condition develops, symptoms can include: tiredness, weight loss, night sweats, tenderness and swelling in the left side of your tummy, feeling full after small meals, pale skin and shortness of breath. Treatment for CML is usually started straight away to help slow down its progression and keep it under control. The main treatments for CML are medicines called tyrosine kinase inhibitors that stop the cancer cells growing and multiplying. They can help keep CML under control if taken for life. CML is a serious and life-threatening condition, but with the introduction of newer tyrosine kinase inhibitors, the outlook is much better now than it used to be. It is estimated that around 70% of men and 75% of women will live for at least 5 years after their diagnosis. Younger adults tend to have a better outlook than older adults. CML is caused by a genetic change (mutation) in the stem cells produced by the bone marrow. The mutation causes the stem cells to produce too many underdeveloped white blood cells. It also leads to a reduction in the number of other blood cells, such as red blood cells.

 

Chronic Myeloid Leukaemia- Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Chronic Myeloid Leukaemia pipeline landscape is provided which includes the disease overview and Chronic Myeloid Leukaemia treatment guidelines. The assessment part of the report embraces, in depth Chronic Myeloid Leukaemia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Chronic Myeloid Leukaemia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Chronic Myeloid Leukaemia R&D. The therapies under development are focused on novel approaches to treat/improve Chronic Myeloid Leukaemia. 

Chronic Myeloid Leukaemia Emerging Drugs Chapters

This segment of the Chronic Myeloid Leukaemia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

 

Chronic Myeloid Leukaemia Emerging Drugs

 

Navtemadlin : Kartos Therapeutics

Navtemadlin (KRT-232) is a novel, potent, and selective oral MDM2 inhibitor. Currently, the drug is undergoing an Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined with a Tyrosine Kinase Inhibitor (TKI) in Patients with Relapsed or Refractory Ph+ Chronic Myeloid Leukemia (CML).

 

Ropeginterferon alfa 2b : AOP Orphan Pharmaceuticals

Ropeginterferon alfa-2b was discovered by PharmaEssentia Corp. based in Taiwan. BESREMi (Ropeginterferon alfa-2b) is a novel, long-acting, mono-pegylated proline interferon .Its pharmacokinetic properties offer a new level of tolerability. 

Further product details are provided in the report……..

Chronic Myeloid Leukaemia: Therapeutic Assessment

This segment of the report provides insights about the different Chronic Myeloid Leukaemia drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in Chronic Myeloid Leukaemia

There are approx. 20+ key companies which are developing the therapies for Chronic Myeloid Leukaemia. The companies which have their Chronic Myeloid Leukaemia drug candidates in the most advanced stage, i.e. phase II include, AOP Orphan Pharmaceuticals.

Phases

DelveInsight’s report covers around 20+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of 
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

 

Chronic Myeloid Leukaemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as 

  • Intra-articular
  • Intraocular
  • Intrathecal 
  • Intravenous
  • Ophthalmic
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Transdermal
  • Molecule Type

 

Products have been categorized under various Molecule types such as

  • Oligonucleotide
  • Peptide
  • Small molecule
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Chronic Myeloid Leukaemia: Pipeline Development Activities 

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Chronic Myeloid Leukaemia therapeutic drugs key players involved in developing key drugs. 

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Chronic Myeloid Leukaemia drugs.

Chronic Myeloid Leukaemia Report Insights

  • Chronic Myeloid Leukaemia Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Chronic Myeloid Leukaemia Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Chronic Myeloid Leukaemia drugs?
  • How many Chronic Myeloid Leukaemia drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Chronic Myeloid Leukaemia?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Chronic Myeloid Leukaemia therapeutics? 
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies? 
  • What are the clinical studies going on for Chronic Myeloid Leukaemia and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Chronic Myeloid Leukaemia: Overview

  • Causes
  • Mechanism of Action 
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type 

Chronic Myeloid Leukaemia– DelveInsight’s Analytical Perspective

Late Stage Products (Phase III)

  • Comparative Analysis

 Drug Name : Company Name

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Mid Stage Products (Phase I/ II)

  • Comparative Analysis

Navtemadlin : Kartos Therapeutics

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Early Stage Products (Phase I) 

  • Comparative Analysis

Drug Name: Company Name

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Preclinical and Discovery Stage Products 

  • Comparative Analysis

Drug Name: Company Name

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Chronic Myeloid Leukaemia Key Companies

Chronic Myeloid Leukaemia Key Products

Chronic Myeloid Leukaemia- Unmet Needs

Chronic Myeloid Leukaemia- Market Drivers and Barriers

Chronic Myeloid Leukaemia- Future Perspectives and Conclusion

Chronic Myeloid Leukaemia Analyst Views

Chronic Myeloid Leukaemia Key Companies

List of Table

Table 1: Total Products for Chronic Myeloid Leukemia

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type                                              

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Chronic Myeloid Leukemia

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type                                                                       

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Product

• Kartos Therapeutics
• AOP Orphan Pharmaceuticals
• Biokine Therapeutics
• Incyte Corporation
• Sana Biotechnology
• Novartis
• Nerviano Medical Sciences
• Sun Pharma Advanced Research Company

 

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