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Vagus Nerve Stimulator (VNS) - Global Market Insights, Competitive Landscape, and Market Forecast - 2028
  • Published Date : Apr 2023

  • Pages : 150

  • Delivery Time : 3-5 Business Days

  • Region : Global

Vagus Nerve Stimulator (VNS) Market

Vagus Nerve Stimulators Market By Product Type (Invasive VNS Devices and Non-Invasive VNS Devices), Application (Migraine, Epilepsy, Depression, and Others), End-User (Hospitals, Specialty Clinics, and Others), and Geography is expected to grow at a steady CAGR (forecast period- 2023-2028) owing to increasing prevalence of neurological disorders and growing popularity of non-invasive VNS devices

The global vagus nerve stimulators market was valued at USD 426.22 million in 2022, growing at a CAGR of 9.06% during the forecast period from 2023 to 2028 to reach USD 717.17 million by 2028. The demand for vagus nerve stimulators is witnessing a surge primarily due to the rising prevalence of neurological diseases such as epilepsy, headache disorders such as migraine, and others that have proven to receive benefit from VNS therapy, increasing popularity of VNS therapy as an alternative or even conjunctive treatment in cases where drug resistance develops, growing research in studying the effects of VNS on other indications such as tinnitus and chronic pain besides the approved ones, technological advancements leading to the development of new products such as non-invasive VNS devices thereby boosting the growth of the vagus nerve stimulators market during the forecast period from 2023-2028.

Vagus Nerve Stimulators Market Dynamics

Vagus Nerve Stimulators Market Dynamics:

The vagus nerve stimulators market is experiencing an increase in product demand for a variety of reasons with one of the key reasons being the rising prevalence of neurological disorders. As per the data cited by the World Health Organization (WHO) (2023), over 50 million people across the globe suffer from epilepsy. The source further stated that the estimated proportion of the general population with active epilepsy (i.e. persistent seizures or that require treatment) at any given time is between 4 and 10 per 1000 people. Additionally, in another factsheet by the WHO, it was stated that approximately 264 million people suffer from depression globally. Neurological indications such as epilepsy and depression can be extremely debilitating for patients and often become refractory to pharmacological treatments. Moreover, pharmacological treatments in such indications are often accompanied by severe side effects.

Owing to these, an alternative approach such as vagus nerve stimulation has been a preferred mode of treatment in drug-resistant cases of depression, and epilepsy as well as it is also being administered in combination with pharmacological treatments to provide a synergistic effect to patients. Vagus nerve stimulation has been reported to provide positive results in terms of preventing seizures in epileptic patients. Additionally, many studies reported that patients who received vagus nerve stimulation for epilepsy showed clinical improvement with depression unrelated to the effect of the VNS on their seizures with nearly 40-50% improvement in patients with non-psychotic major depression.

Moreover, with more positive results being reported concerning the VNS therapy, more research is being conducted on different disease areas which may further expand the application of vagus nerve stimulation in coming years. For instance, several studies are ongoing in studying the effects of VNS on tinnitus, irritable bowel syndrome, and chronic pain among other indications. This further presents an opportunity for making significant headway in the VNS market shortly.

However, procedure-related complications and the high cost of these devices may be confining factors for the vagus nerve stimulators market growth.

Vagus Nerve Stimulators Market Segment Analysis:

Vagus Nerve Stimulators Market by Product Type (Invasive VNS Devices and Non-Invasive VNS Devices), Application (Migraine, Epilepsy, Depression, and Others), End-User (Hospitals, Specialty Clinics, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World).

In the product segment of the vagus nerve stimulators market, the non-invasive VNS devices category is expected to register a healthy CAGR in the vagus nerve stimulators market during the forecast period. This can be attributed to the advantages offered by these devices over their counterparts. Implantable VNS devices are often associated with adverse events encompassing both the surgical procedure and the electrical stimulation itself. Therefore, non-invasive VNS (nVNS) devices were developed to address the shortcomings associated with invasive VNS devices.

Subsequently, non‐invasive VNS (nVNS) delivery options that eliminate the need for surgical implantation were developed. These VNS delivery systems help in avoiding surgery‐related adverse events such as infections and cardiac complications. Additionally, nVNS devices further help in addressing limitations of implantable VNS devices such as the continuous on−off stimulation cycle of implantable devices as the nVNS devices can be adjusted to balance tolerability and efficacy by end users. A few of the non-invasive vagus nerve stimulators that are currently available for commercial use are gammaCore, Sapphire by electroCore, and Parasym device by Parasym Ltd.

Thus, all the above-listed factors are likely to propel the growth of the market for non-invasive VNS devices, ultimately driving the growth of the overall vagus nerve stimulators market.

North America is expected to dominate the overall Vagus Nerve Stimulators Market:

Among all the regions, North America is estimated to account for the largest share of the vagus nerve stimulators market. The key driving factors of the North America vagus nerve stimulators market are the high prevalence of epilepsy, depression in the region, increasing disposable income, and rising investments and big collaborative expansions by key players in the region. Moreover, the conducive regulatory environment in the region is expected to establish the dominance of the North America VNS market in the overall global landscape.

One of the key driving factors of the United States vagus nerve stimulators market is the interplay of various factors in the country. This domination is due to the increase in the epileptic population, and the increasing prevalence of headache disorders such as migraine, and depression in the country. Furthermore, extensive research and development activities about product development and a conducive regulatory environment further help product manufacturers to generate more revenue from the country.

For instance, as per the data cited by the National Headache Association (2023), approximately 40 million Americans are living with migraine and headache disorders in the country. Therefore, the presence of a large patient population suffering from migraine and headache disorders correlates to the presence of a potential patient population that may resort to using VNS devices as a treatment method, thus driving the product demand in the nation. Moreover, the increasing epileptic population is also expected to drive the demand for vagus nerve stimulators in the country. For instance, as per the data provided by the Centers for Disease Control and Prevention (2023), in 2015, about 3.4 million people across the nation were diagnosed with epilepsy of which 470,000 were children. As mentioned by the International League Against Epilepsy, one-third of the epileptic patient population continues to have seizures despite being on anti-seizure medication. This presents another opportunity for VNS devices as they have been reported and approved for medical use for treating drug-resistant epilepsy.

Also, advanced product launches and commercialization agreements among the key companies are further expected to fuel the market. For instance, in August 2021, the US Food and Drug Administration approved a drug-free rehabilitation system intended to treat moderate to severe upper extremity motor deficits associated with chronic ischemic stroke—a stroke caused by a blockage of blood flow to the brain with long-lasting symptoms the first-of-its-kind VNS device- the MicroTransponder Vivistim Paired VNS System. Thus, the interplay of all the aforementioned factors is likely to fuel the market growth of vagus nerve stimulators in the United States during the forecast period

Besides the United States, product development activities in Canada also provide supportive growth opportunities for the North America vagus nerve stimulators market. For instance, the Canadian Health regulatory body Health Canada authorized the Dolphin vagus nerve stimulator for emergency use in the treatment of COVID-19-induced acute respiratory distress syndrome.

Thus, all these activities point towards the presence of a conducive growth environment in the North American region, ultimately influencing the market growth of this regional market.

Vagus Nerve Stimulators Market Key Players:

Some of the key market players operating in the vagus nerve stimulators market include LivaNova, Soterix Medical Inc, MicroTransponder Inc, Parasym Ltd, electroCore, tVNS Technologies GmbH, and others.

Recent Developmental Activities in Vagus Nerve Stimulators Market:

  • In August 2021, the US Food and Drug Administration approved the MicroTransponder Vivistim Paired VNS System, a one-of-its-kind, drug rehabilitation system to treat moderate to severe upper extremity motor deficits associated with chronic ischemic stroke.
  • In March 2020, LivaNova received the CE Mark approval for their Vagus Nerve Stimulation Therapy® (VNS Therapy) System, Symmetry™ for difficult-to-treat depression.

Report Metrics

Details

Study Period

2020 to 2028

Base Year

2022

Forecast Period

2023 to 2028

CAGR

9.06%

Market Size

USD 717.17 million by 2028

Key Companies

LivaNova, Soterix Medical Inc, MicroTransponder Inc, Parasym Ltd, electroCore, tVNS Technologies GmbH, and others.

Key Takeaways from the Vagus Nerve Stimulators Market Report Study

  • Market size analysis for current vagus nerve stimulators market size (2022), and market forecast for 5 years (2023-2028)
  • Top key product/services/technology developments, mergers, acquisitions, partnerships, and joint ventures happened for the last 3 years
  • Key companies dominating the global vagus nerve stimulators market.
  • Various opportunities are available for the other competitor in the vagus nerve stimulators market space.
  • What are the top-performing segments in 2022? How these segments will perform in 2028?
  • Which are the top-performing regions and countries in the current vagus nerve stimulators market scenario?
  • Which are the regions and countries where companies should have concentrated on opportunities for vagus nerve stimulators market growth in the coming future?

Target Audience who can benefited from This Vagus Nerve Stimulators Market Report Study

  • Vagus nerve stimulators products providers
  • Research organizations and consulting companies
  • Vagus nerve stimulators-related organizations, associations, forums, and other alliances
  • Government and corporate offices
  • Start-up companies, venture capitalists, and private equity firms
  • Distributors and Traders dealing in vagus nerve stimulators
  • Various End-users who want to know more about the vaginal rejuvenation systems market and the latest technological developments in the vaginal rejuvenation systems market.

1. Vagus Nerve Stimulators Market Report Introduction

2. Vagus Nerve Stimulators Market Executive Summary

2.1. Scope of the Study

2.2. Market at Glance

2.3. Competitive Assessment

3. Regulatory Analysis

3.1. The United States

3.2. Europe

3.3. Japan

3.4. China

4. Vagus Nerve Stimulators Market Key Factors Analysis

4.1. Vagus Nerve Stimulators Market Drivers

4.1.1. Rising Prevalence of Neurological Disorders

4.1.2. Increasing Focus Toward Alternative Treatments

4.1.3. Growing Focus on Expanding Application Area of VNS Therapy

4.1.4. Technological Advancements in Product Development

4.2. Vagus Nerve Stimulators Market Restraints and Challenges

4.2.1. Procedure-Related Complications

4.2.2. High Cost of Devices

4.3. Vagus Nerve Stimulators Market Opportunities

4.3.1. Improving on the Product Design

4.3.2. Targeting Emerging Markets for Product Launches

5. Vagus Nerve Stimulators Market Porter’s Five Forces Analysis

5.1. Bargaining Power of Suppliers

5.2. Bargaining Power of Consumers

5.3. Threat of New Entrants

5.4. Threat of Substitutes

5.5. Competitive Rivalry

6. Vagus Nerve Stimulators Market Layout

6.1. By Product Type

6.1.1. Invasive VNS Devices

6.1.2. Non-invasive VNS Devices

6.2. By Application

6.2.1. Migraine

6.2.2. Epilepsy

6.2.3. Depression

6.2.4. Others

6.3. By End-User

6.3.1. Hospitals

6.3.2. Specialty Clinics

6.3.3. Others

6.4. By Geography

6.4.1. North America Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.1.1. United States Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.1.2. Canada Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.1.3. Mexico Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2. Europe Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.1. France Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.2. Germany Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.3. United Kingdom Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.4. Italy Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.5. Spain Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.2.6. Rest of Europe Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3. Asia-Pacific Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.1. China Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.2. Japan Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.3. India Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.4. Australia Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.5. South Korea Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.3.6. Rest of Asia Pacific Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.4. Rest of the World (RoW) Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.4.1. Middle East Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.4.2. Africa Vagus Nerve Stimulators Market Size in USD million (2020-2028)

6.4.4.3. South America Vagus Nerve Stimulators Market Size in USD million (2020-2028)

7. Vagus Nerve Stimulators Market Company and Product Profiles

7.1. LivaNova

7.1.1. Company Overview

7.1.2. Company Snapshot

7.1.3. Financial Overview

7.1.4. Product Listing

7.1.5. Entropy

7.2. Soterix Medical Inc

7.2.1. Company Overview

7.2.2. Company Snapshot

7.2.3. Financial Overview

7.2.4. Product Listing

7.2.5. Entropy

7.3. MicroTransponder Inc

7.3.1. Company Overview

7.3.2. Company Snapshot

7.3.3. Financial Overview

7.3.4. Product Listing

7.3.5. Entropy

7.4. Parasym Ltd

7.4.1. Company Overview

7.4.2. Company Snapshot

7.4.3. Financial Overview

7.4.4. Product Listing

7.4.5. Entropy

7.5. electroCore

7.5.1. Company Overview

7.5.2. Company Snapshot

7.5.3. Financial Overview

7.5.4. Product Listing

7.5.5. Entropy

7.6. tVNS Technologies GmbH

7.6.1. Company Overview

7.6.2. Company Snapshot

7.6.3. Financial Overview

7.6.4. Product Listing

7.6.5. Entropy

7.7. Neuvana

7.7.1. Company Overview

7.7.2. Company Snapshot

7.7.3. Financial Overview

7.7.4. Product Listing

7.8. Vagustim

7.8.1. Company Overview

7.8.2. Company Snapshot

7.8.3. Financial Overview

7.8.4. Product Listing

7.8.5. Entropy

8. KOL Views

9. Project Approach

10. DelveInsight Capabilities

11. About DelveInsight

12. Disclaimer & Contact Us

List of Tables:

  • Table 1: Competitive Analysis
  • Table 2: Vagus Nerve Stimulators Market in Global (2020-2028)
  • Table 3: Vagus Nerve Stimulators Market in Global by Product Type (2020-2028)
  • Table 4: Vagus Nerve Stimulators Market in Global by Application (2020-2028)
  • Table 5: Vagus Nerve Stimulators Market in Global by End-User (2020-2028)
  • Table 6: Vagus Nerve Stimulators Market in Global by Geography (2020-2028)
  • Table 7: Vagus Nerve Stimulators Market in North America (2020-2028)
  • Table 8: Vagus Nerve Stimulators Market in the US (2020-2028)
  • Table 9: Vagus Nerve Stimulators Market in Canada (2020-2028)
  • Table 10: Vagus Nerve Stimulators Market in Mexico (2020-2028)
  • Table 11: Vagus Nerve Stimulators Market in Europe (2020-2028)
  • Table 12: Vagus Nerve Stimulators Market in France (2020-2028)
  • Table 13: Vagus Nerve Stimulators Market in Germany (2020-2028)
  • Table 14: Vagus Nerve Stimulators Market in the United Kingdom (2020-2028)
  • Table 15: Vagus Nerve Stimulators Market in Italy (2020-2028)
  • Table 16: Vagus Nerve Stimulators Market in Spain (2020-2028)
  • Table 17: Vagus Nerve Stimulators Market in Rest of Europe (2020-2028)
  • Table 18: Vagus Nerve Stimulators Market in Asia-Pacific (2020-2028)
  • Table 19: Vagus Nerve Stimulators Market in China (2020-2028)
  • Table 20: Vagus Nerve Stimulators Market in Japan (2020-2028)
  • Table 21: Vagus Nerve Stimulators Market in India (2020-2028)
  • Table 22: Vagus Nerve Stimulators Market in Australia (2020-2028)
  • Table 23: Vagus Nerve Stimulators Market in South Korea (2020-2028)
  • Table 24: Vagus Nerve Stimulators Market in Rest of Asia-Pacific (2020-2028)
  • Table 25: Vagus Nerve Stimulators Market in Rest of World (2020-2028)
  • Table 26: Vagus Nerve Stimulators Market in RoW by Region (2020-2028)
  • Table 27: Vagus Nerve Stimulators Market in the Middle East (2020-2028)
  • Table 28: Vagus Nerve Stimulators Market in Africa (2020-2028)
  • Table 29: Vagus Nerve Stimulators Market in South America (2020-2028)

List of Figures:

  • Figure 1: Competitive Analysis
  • Figure 2: Vagus Nerve Stimulators Market in Global (2020-2028)
  • Figure 3: Vagus Nerve Stimulators Market in Global by Product Type (2020-2028)
  • Figure 4: Vagus Nerve Stimulators Market in Global by Application (2020-2028)
  • Figure 5: Vagus Nerve Stimulators Market in Global by End-User (2020-2028)
  • Figure 6: Vagus Nerve Stimulators Market in Global by Geography (2020-2028)
  • Figure 7: Vagus Nerve Stimulators Market in North America (2020-2028)
  • Figure 8: Vagus Nerve Stimulators Market in the US (2020-2028)
  • Figure 9: Vagus Nerve Stimulators Market in Canada (2020-2028)
  • Figure 10: Vagus Nerve Stimulators Market in Mexico (2020-2028)
  • Figure 11: Vagus Nerve Stimulators Market in Europe (2020-2028)
  • Figure 12: Vagus Nerve Stimulators Market in France (2020-2028)
  • Figure 13: Vagus Nerve Stimulators Market in Germany (2020-2028)
  • Figure 14: Vagus Nerve Stimulators Market in the United Kingdom (2020-2028)
  • Figure 15: Vagus Nerve Stimulators Market in Italy (2020-2028)
  • Figure 16: Vagus Nerve Stimulators Market in Spain (2020-2028)
  • Figure 17: Vagus Nerve Stimulators Market in the Rest of Europe (2020-2028)
  • Figure 18: Vagus Nerve Stimulators Market in Asia-Pacific (2020-2028)
  • Figure 19: Vagus Nerve Stimulators Market in China (2020-2028)
  • Figure 20: Vagus Nerve Stimulators Market in Japan (2020-2028)
  • Figure 21: Vagus Nerve Stimulators Market in India (2020-2028)
  • Figure 22: Vagus Nerve Stimulators Market in Australia (2020-2028)
  • Figure 23: Vagus Nerve Stimulators Market in South Korea (2020-2028)
  • Figure 24: Vagus Nerve Stimulators Market in the Rest of Asia-Pacific (2020-2028)
  • Figure 25: Vagus Nerve Stimulators Market in the Rest of the World (2020-2028)
  • Figure 26: Vagus Nerve Stimulators Market in the Middle East (2020-2028)
  • Figure 27: Vagus Nerve Stimulators Market in Africa (2020-2028)
  • Figure 28: Vagus Nerve Stimulators Market in South America (2020-2028)
  • Figure 29: Market Drivers
  • Figure 30: Market Barriers
  • Figure 31: Marker Opportunities
  • Figure 32: PORTER'S Five Force Analysis

List of Companies:

  • LivaNova
    Soterix Medical Inc
    MicroTransponder Inc
    Parasym Ltd
    electroCore
    tVNS Technologies GmbH

Frequently Asked Questions

A vagus nerve stimulator is a pacemaker-like device that comes with an implantable programmable generator that is implanted in the chest wall and delivers electrical impulses to the vagus nerve in the neck thereby stimulating the vagus nerve and providing relief to patients.

The Global Vagus Nerve Stimulator Market was valued at USD 390.81 million in 2020 and growing at a CAGR of 9.06% during the forecast period from 2021 to 2026, it is expected to reach USD 647.28 million by 2026.

Some of the key factors driving the Global Vagus Nerve Stimulators Market Growth include the rising prevalence of neurological diseases such as epilepsy, headache disorders such as migraine, and others that have proven to receive benefit from VNS therapy, increasing popularity of VNS therapy as an alternative or even conjunctive treatment in cases where drug resistance develops, growing research in studying the effects of VNS on other indications besides the approved ones, technological advancements leading to the development of new products such as non-invasive VNS devices, among others.

Some of the key market players operating in the vagus nerve stimulators market include LivaNova, Soterix Medical Inc, MicroTransponder Inc, Parasym Ltd, electroCore, tVNS Technologies GmbH, and others.

Among all the regions, North America is estimated to account for the largest share of the vagus nerve stimulators market. The key factors driving the Vagus Nerve Stimulators Market Growth in North America include the high prevalence of epilepsy, and depression in the region, increasing disposable income, rising investments, and big collaborative expansions by key players in the region. Moreover, the conducive regulatory environment in the region is expected to establish the dominance of the North America VNS market in the overall global landscape.

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