Continuous Renal Replacement Therapy (CRRT) Market

CRRT Market by Product Type (Machines and Consumables), Modality (Slow Continuous Ultrafiltration (SCUF), Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD), and Continuous Venovenous Hemodiafiltration (CVVHDF)), Patient (Adult and Pediatric), End-User (Hospitals, Dialysis Centres, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World) is expected to advance at a substantial CAGR forecast till 2030 owing to the increasing number of acute kidney injuries and the rising product developmental activities across the globe

The CRRT machines market was valued at USD 1.17 billion in 2023, growing at a CAGR of 7.38% during the forecast period from 2024 to 2030 to reach 1.78 billion by 2030. The CRRT machines market is experiencing significant growth due to the increasing instances of acute kidney injury and sepsis, coupled with advancements in technology and product launches which are acting as major factors contributing to the overall growth of the CRRT machines market during the forecast period from 2024 to 2030.

CRRT Machines Market Dynamics:

 As per data from the International Society of Nephrology 2021, each year, there are around 13.3 million cases of acute kidney injury (AKI) globally and the increased burden is on emerging countries where the annual incidence is estimated to be 11.3 million. In regions with a high incidence of AKI, CRRT provides continuous, gentle renal support that can be crucial for managing fluid balance and removing waste products when patients are critically ill. The therapy is especially beneficial in environments where traditional intermittent dialysis may be less feasible due to the patient's unstable condition or limited resources.

According to the recently updated data in 2024 from the Global Sepsis Alliance, sepsis is a global health crisis that afflicts almost 47 to 50 million individuals each year. CRRT machines are employed to manage sepsis to provide continuous renal support, helping regulate fluid balance, remove toxins, and support overall organ function. In addition to this, the World Sepsis Day was initiated by the Global Sepsis Alliance in 2012. Each year on September 13th, events were held around the world to raise awareness for sepsis. These events included activities for medical professionals, sports events, photo exhibitions, pink picnics, gala events, dinners, public gatherings such as open houses in hospitals and healthcare facilities, and various online events.

Additionally, the product developmental activities such as launches in the Europe region are also pushing forward the revenue shares of CRRT machines. For example in May 2021, Baxter International Inc launched PrisMax 2, the latest version of the company’s next-generation platform. PrisMax 2 helps simplify the delivery of continuous renal replacement therapy (CRRT) and other organ support therapies. The PrisMax 2 featured new solutions within the company’s TrueVue digital health portfolio, as well as the PrismaLung+ blood-gas exchanger, which delivered extracorporeal carbon dioxide removal (ECCO2R) therapy to support the management of acute respiratory dysfunction. PrismaLung+ was available in selected markets in Western Europe.

Hence, the interplay of all the factors mentioned above is expected to drive the CRRT machines market during the given forecast period from 2024 to 2030.

However, CRRT affecting blood pressure, fluid imbalance associated with hemodynamic instability, and alteration of electrolyte levels in the blood, among others may restrict the market growth.

CRRT Machines Market Segment Analysis:

CRRT Market by Product Type (Machines and Consumables), Modality (Slow Continuous Ultrafiltration (SCUF), Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD), and Continuous Venovenous Hemodiafiltration (CVVHDF)), Patient (Adult and Pediatric), End-User (Hospitals, Dialysis Centres, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World)

In the modality segment of the CRRT machines market, the continuous venovenous hemodialysis (CVVHD) category is expected to have a significant revenue share in the year 2023. This is because CVVHD is commonly used primarily for critically ill patients with acute kidney injury or chronic kidney failure. This modality features several distinct characteristics and applications. One of its key features is the continuous, gentle filtration of blood. CVVHD operates by drawing blood from the patient’s venous system, passing it through a dialyzer where toxins and excess fluids are removed, and then returning the filtered blood to the patient. This process helps maintain stable fluid balance, electrolyte levels, and acid-base homeostasis.

The technology's applications are broad, including its use in managing severe fluid overload, critical sepsis, multi-organ dysfunction syndrome (MODS), and various forms of metabolic imbalances. Additionally, it provides an option for patients with complex medical conditions, such as severe cardiovascular instability, or those recovering from major surgeries, where traditional dialysis might be too aggressive.

Moreover, product innovation in this also drives the market for the same. For example in August 2023, Quanta Dialysis Technologies®, a medical technology company dedicated to enhancing kidney care accessibility, announced the FDA 510(k) clearance for an expanded indication of the Quanta Dialysis System. This compact and user-friendly hemodialysis device was approved for use in continuous venovenous hemodialysis (CVVHD).

Therefore the widespread uses and various advantages of CVVHD enhance performance and usability, solidifying the significant impact on the growth of the overall CRRT machines market during the forecast period from 2024 to 2030.

North America is expected to dominate the overall CRRT machines market:

Among all the regions, North America is estimated to hold a significant revenue share in the CRRT Machines market. This can be attributed to several factors, including the prevalence of end-stage renal disease (ESRD), ongoing product development activities by regulatory authorities, and the availability of prompt and well-established healthcare facilities, supported by the presence of key players in the region are the key factors that contribute to the growth of the CRRT machines market in the North America region during the forecast period from 2024 to 2030.

According to the US Department of Health and Human Services 2021, end-stage renal disease (ESRD) is a significant public health problem in the United States and a major source of suffering and poor quality of life for those afflicted. CRRT machines provide continuous renal support, which is particularly beneficial for patients with severe symptoms or complications. By performing gentle, continuous filtration of blood, CRRT machines help manage fluid balance, remove waste products, and stabilize electrolyte levels. This approach can improve patient outcomes, alleviate symptoms, and enhance the overall quality of life for those with advanced renal conditions.

Various product development strategies such as clearances in the region by regulatory authorities in the region play a major role in pushing forward the revenue shares of CRRT machines in the region. For example, in December 2023, AcelRx Pharmaceuticals, Inc. announced the publication of a quantitative market research study that evaluated current U.S. physician anticoagulation practices during continuous renal replacement therapy (CRRT) for patients with acute kidney injury in the intensive care unit. Heparin, the only FDA-approved anticoagulant for dialysis circuits at the time, had a half-life of 1-3 hours. The FDA had granted Emergency Use Authorization (EUA) to citrate, which was classified as a ""regional"" anticoagulant. Its effect was reversed with a calcium infusion administered to the patient, thereby limiting its anticoagulant action on the circuit.

Moreover, the constant focus of market players in the targeting regions for product launches is further expected to propel the growth of the North America CRRT machines market.

Therefore, the interplay of all the factors mentioned above would provide a conducive growth environment for the North America region in the CRRT machines market during the forecast period from 2024 to 2030.

CRRT Machines Market key players:

Some of the key market players operating in the CRRT Machines market include Baxter, Fresenius Medical Care AG, NIKKISO CO., LTD, B.Braun Melsungen AG, Asahi Kasei Corporation, Infomed SA, Medtronic, NxStage Medical, Inc., Medica S.p.A., SWS Hemodialysis Care Co., Ltd, Dialco Medical Inc, Anjue Medical Equipment Co. Ltd, Medica S.p.A., Jiangxi Sanxin Medtec Co. Ltd, and others.

Recent Developmental Activities in the CRRT Machines Market:

• In July 2024, the University of California, Los Angeles-led team developed a machine-learning model that accurately predicted the short-term survival of dialysis patients undergoing continuous renal replacement therapy (CRRT).
• In February 2021, Cincinnati Children's Hospital Medical Center began treating critically ill infants in renal failure with a new device designed to improve outcomes for smaller, fragile babies. The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) was a new system for patients with acute kidney injury or kidney failure requiring dialysis. This groundbreaking technology was intended to provide continuous renal replacement therapy (CRRT) to patients weighing between 5 and 20 pounds.

Key takeaways from the CRRT Machines market report study

• Market size analysis for current CRRT machines market size (2023), and market forecast for 6 years (2024 to 2030)
• Top key product/services developments, mergers, acquisitions, partnerships, and joint ventures happened for the last 3 years
• Key companies dominating the CRRT machines market
• Various opportunities available for the other competitors in the CRRT machines market space
• What are the top-performing segments in 2023? How these segments will perform in 2030?
• Which are the top-performing regions and countries in the current CRRT machines market scenario?
• Which are the regions and countries where companies should have concentrated on opportunities for CRRT machines market growth in the coming future?

Target audience who can be benefited from this CRRT Machines market report study

• CRRT machine providers
• Research organizations and consulting companies 
• CRRT machines related organizations, associations, forums, and other alliances
• Government and corporate offices
• Start-up companies, venture capitalists, and private equity firms
• Distributors and traders dealing in CRRT machines
• Various end-users who want to know more about the CRRT machines market and the latest developments in the CRRT machines market