Obstructive Sleep Apnea Osa Pipeline Insight

DelveInsight’s, “Obstructive Sleep Apnea (OSA) - Pipeline Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Obstructive Sleep Apnea (OSA) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Obstructive Sleep Apnea (OSA) Understanding

Obstructive Sleep Apnea (OSA): Overview

Obstructive sleep apnea (OSA) is characterized by episodes of breathing cessation or shallow breathing in sleep. These episodes are due to complete or partial collapse of upper airway. Most of the time, the respiratory events are associated with snoring, oxygen desaturations and brief arousal from sleep. Sleep apnea is usually worse during supine and Rapid Eye Movement (REM) sleep. There could be exacerbation of snoring and OSA with alcohol consumption or ingestion of sedative medications. OSA is common and the prevalence is increasing with the increased prevalence of obesity. Daytime sleepiness is among the most common symptoms, but many patients with OSA are asymptomatic. Patients with OSA who are asymptomatic, or whose symptoms are minimally bothersome and pose no apparent risk to driving safety, can be treated with behavioral measures, such as weight loss and exercise. Common obstructive sleep apnea warning signs include: Daytime sleepiness or fatigue, dry mouth or sore throat when person wake up ,headaches in the morning ,trouble concentrating, forgetfulness, depression, or crankiness, night sweats, restlessness during sleep. Complications of obstructive sleep apnea can include: Sleepiness during the day and trouble concentrating. Adults may have a higher risk of accidents, and children may have a hard time at school. Cardiovascular problems such as heart attack, high blood pressure, unusual heart rhythms, or stroke, eye problems such as glaucoma and dry eye and metabolic disorders like type 2 diabetes. The prevalence of symptomatic OSA or OSA syndrome was only 2% in women versus 4% in men. Obesity is a major risk factor for OSA. OSA is seen in up to 70% of morbidly obese individuals. Other risk factors include advancing age and craniofacial deformities. OSA is also common in smokers, individuals with family history of OSA and in postmenopausal females. Prevalence of OSA increases with coexisting medical conditions like – pregnancy, atrial fibrillation, stroke, congestive heart failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), hypothyroidism, and Polycystic Ovary Syndrome (PCOS).

 

"Obstructive Sleep Apnea- Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Obstructive Sleep Apnea pipeline landscape is provided which includes the disease overview and Obstructive Sleep Apnea treatment guidelines. The assessment part of the report embraces, in depth Obstructive Sleep Apnea commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Obstructive Sleep Apnea collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Obstructive Sleep Apnea R&D. The therapies under development are focused on novel approaches to treat/improve Obstructive Sleep Apnea. 

Obstructive Sleep Apnea Emerging Drugs Chapters

This segment of the Obstructive Sleep Apnea report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

 

Obstructive Sleep Apnea Emerging Drugs


Lemborexant : Eisai

Lemborexant, is an orexin receptor antagonist that blocks the receptors involved in the regulation of sleep and wakefulness. It is expected to alleviate wakefulness, thereby facilitating faster onset and maintenance of sleep. The drug has recently completed the Phase I trial for the Obstructive Sleep Apnea.

 

Sulthiame : Desitin Arzneimittel GmbH

Sulthiame is an investigational drug. There have been 4 clinical trials for Sulthiame. The most common disease conditions in clinical trials are Epilepsy, Epilepsy, Rolandic, and Sleep Apnea, Obstructive. Currently the drug is in Phase II for the treatment of Obstructive Sleep Apnea.

 

AD 182 : Apnimed

AD109 is a first-in-class, oral pharmaceutical combination dosed once-daily at bedtime, designed to treat OSA patients across a broad spectrum of disease severity. AD109 combines a selective norepinephrine reuptake inhibitor (NRI), atomoxetine, with a novel NCE selective antimuscarinic, aroxybutynin. The investigational drug is designed to be safe, effective, and convenient, addressing the key limitations of the current standard of care treatments. AD036 improved multiple objective measures of OSA as well as OSA symptoms, providing proof-of-concept that an oral pharmacologic approach may have clinical benefit in patients with OSA.

 

TAK-925 : Takeda

TAK-925, being studied as an orexin agonist which works selectively on orexin 2 receptors, in sleep-wake disorders characterized by excessive daytime sleepiness (EDS). TAK-925, demonstrated a statistically significant improvement in mean sleep latency measured by the Maintenance of Wakefulness Test (MWT) versus placebo. Currently, the drug is in Phase I stage of development for the treatment of OSA.

Further product details are provided in the report……..

Obstructive Sleep Apnea: Therapeutic Assessment

This segment of the report provides insights about the different Obstructive Sleep Apnea drugs segregated based on following parameters that define the scope of the report, such as:

 

Major Players in Obstructive Sleep Apnea

There are approx. 20+ key companies which are developing the therapies for Obstructive Sleep Apnea. The companies which have their Obstructive Sleep Apnea drug candidates in the most advanced stage, i.e. phase II include, Desitin Arzneimittel GmbH.

 

Phases

DelveInsight’s report covers around 20+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of 
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates

 

Route of Administration

Obstructive Sleep Apnea pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as 

  • Intra-articular
  • Intraocular
  • Intrathecal 
  • Intravenous
  • Ophthalmic
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Transdermal

 

Molecule Type

Products have been categorized under various Molecule types such as

  • Oligonucleotide
  • Peptide
  • Small molecule

 

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Obstructive Sleep Apnea (OSA): Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Obstructive Sleep Apnea (OSA) therapeutic drugs key players involved in developing key drugs.

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Obstructive Sleep Apnea (OSA) drugs.

Obstructive Sleep Apnea (OSA) Report Insights

  • Obstructive Sleep Apnea (OSA) Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Obstructive Sleep Apnea (OSA) Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Obstructive Sleep Apnea (OSA) drugs?
  • How many Obstructive Sleep Apnea (OSA) drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Obstructive Sleep Apnea (OSA)?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Obstructive Sleep Apnea (OSA) therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Obstructive Sleep Apnea (OSA) and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Obstructive Sleep Apnea: Overview

  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Obstructive Sleep Apnea– DelveInsight’s Analytical Perspective

Late Stage Products (Phase III)

  • Comparative Analysis

Drug name : Company name

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

Sulthiame : Desitin Arzneimittel GmbH

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I)

  • Comparative Analysis

Drug name : Company name

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Preclinical and Discovery Stage Products

  • Comparative Analysis

Drug name : Company name

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Obstructive Sleep Apnea Key Companies

Obstructive Sleep Apnea Key Products

Obstructive Sleep Apnea- Unmet Needs

Obstructive Sleep Apnea- Market Drivers and Barriers

Obstructive Sleep Apnea- Future Perspectives and Conclusion

Obstructive Sleep Apnea Analyst Views

Obstructive Sleep Apnea Key Companies

Appendix

List of Table

Table 1: Total Products for Obstructive Sleep Apnea (OSA)

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Obstructive Sleep Apnea (OSA)

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products   

• Apnimed
• Therapix Biosciences
• Eisai
• Idorsia Pharmaceuticals
• Takeda
• Merck & Co
• Taisho Pharmaceutical Co., Ltd.
• Bayer
• Janssen Pharmaceuticals
• RespireRx Pharmaceuticals
• Cortex Pharmaceuticals
• Michael James Enterprises

 

 

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