Articles

Immune checkpoint activators are small molecules responsible for maintenance, modulation and regulation of immune responses. Its significance in Immuno therapeutics is backed by its functionality to activate the immune checkpoint proteins that are down regulated by tumors, leading to the activation of the immune system as a response to combat the tumor. The recent trend with Immune check activators is their combined use with chemotherapy. Currently, there are over 15 companies that have invested in Immune check activators. Much of today’s focus is being put on OX-40 sharing 35% of the pie for Immune checkpoint activators. It is followed by GITR and others like 4-1BB,...