Articles

Familial Amyloid Polyneuropathy (also known as transthyretin amyloidosis, TTR, and FAP) is a group of endangering multisystem disorders which are transmitted as an autosomal dominant trait. It is caused by the excessive accumulation of amyloid in the organs and tissues. The first identified cause of FAP is the Val30Met mutation of the transthyretin (TTR) gene. The symptomatology and clinical course of FAP can be highly variable which includes frequent weight loss and cardiac involvement followed by ocular or renal complications. The clinical presentation and incidence of TTR-FAP vary widely across the globe affecting an estimated 10,000 people worldwide. Research studi...