The oral depression drug of Sage Therapeutics meets phase 3 efficacy
A phase 3 trial of oral treatment of Sage Therapeutics for postpartum depression (PPD) has hit its primary endpoint. The drug, SAGE-217, showed significant improvements on a depression score and saw no fainting cases. SAGE-217 is an allosteric modulator of GABAA receptors. A phase 3 trial of SAGE-217 indicates the convenience has not come at the cost of safety or efficacy. A number of women with severe PPD, SAGE-217 surpassed placebo against multiple measures of depression, including the Hamilton Rating Scale for Depression (HAMD-17) score.
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