Immunological and Autoimmune Disorders

Plaque psoriasis is a chronic autoimmune condition, with a buildup of dead cells as scales giving the affected area of skin a raised and red patchy look. About 2% of population in the US suffers from this disease. A new drug, Taltz (Ixekizumab), has been approved by FDA in March 2016 for its treatment. Taltz (ixekizumab), a selective humanized IgG4 monoclonal antibody, was developed by Eli Lily and Company and inhibits the interaction of interleukin 17A (IL-17A) cytokine and IL-17 receptor by binding to 17A (IL-17A) cytokine. This inhibitory effect of Taltz neutralizes IL-17, IL-14, IL-21, thus blocking beta-defensins, keratinocyte production of cytokines and antimicro...