Killing brain tumors with the help of CAR-T
CAR-T cell therapy is a technique which involves modifying patients' T cells to aim proteins associated with cancer that have revolutionized some of the blood cancers treatment. However, the technique has so far shown low potential in solid tumors like aggressive brain cancer- glioblastoma.
Now, researchers at the City of Hope have created a novel chimeric antigen receptor (CAR) based on chlorotoxin (CLTX), a toxin present in scorpion venom. T cells armed with that CAR positively killed tumors in mice with glioblastoma xenografts without stimulating any unwanted consequences, the team informed in a study published in S...