Articles

JAK inhibitors also termed “Jakinibs,” work by inhibiting the activity and response of one or more Janus kinase enzymes. These inhibitors function against the Janus kinases, a group of four proteins that includes JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). These proteins control inflammation by triggering intracytoplasmic transcription factors known as signal transducers and activators of transcription (STAT). Talking about physiology, they are the intracellular enzymes that transmit signals from cytokines ratified to cell surface receptors to signal transducers and activators of transcription responsible for proinflammatory cellular responses. The pathophysio...