Oncology

Subsequent malignant neoplasms (SMNs) are one of the most serious and potentially lethal complications of cancer and its therapy. Radiotherapy has been known to be a human carcinogen, however, a growing body bolsters the selective contribution of chemotherapeutic agents to SMN risk. Cisplatin binds to and destructs DNA, hence producing partly reactive platinum in the serum and platinum–DNA adducts in human organs that are detectable up to 20 years after the completion of chemotherapy. In particular, any synergistic mechanistic effects of platinum with other carcinogens remain unclear. In the study, bladder cancer accounted for the largest absolute excess risk (17.1%) ...