Leptomeningeal metastases, also known as leptomeningeal disease, carcinomatous meningitis, or neoplastic meningitis, represent a serious complication of advanced cancer in which malignant cells spread through the cerebrospinal fluid (CSF) to infiltrate the protective membranes surrounding the brain and spinal cord. While this condition affects approximately 5-8% of patients with metastatic solid tumors, undiagnosed cases may be considerably more common. Any cancer can potentially cause leptomeningeal metastases, but the condition is most frequently associated with lung cancer, breast cancer, melanoma, and gastrointestinal malignancies.
Understanding the Disease Bur...
