FDA Approves LUMAKRAS and VECTIBIX for KRAS G12C-Mutated Colorectal Cancer
Amgen has secured FDA approval for LUMAKRAS (sotorasib) in combination with VECTIBIX (panitumumab) as a treatment for adults with KRAS G12C-mutated metastatic colorectal cancer (mCRC) who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. This approval is underpinned by the Phase III CodeBreaK 300 study, which showcased the combination's ability to significantly enhance progression-free survival (PFS) compared to existing standards of care. The approval marks a significant step forward in providing targeted therapy for this specific patient populatio...