Oncology

The discovery of Cyclin Dependent Kinases (CDKs) is a result of increasing number of cancer cases worldwide. The development of CDKs has changed the paradigm for cancer treatment and it has gradually become an interesting area of research in oncology. The research on CDK inhibitors gained momentum because of the frequent perturbations in human malignancy and the activity of CDK inhibitors in the induction of apoptosis during cell cycle arrest. The major focus is to develop first generation CDK 4/6 inhibitors and then proceed to second generation as they are more efficient and less toxic antineoplastic agents than molecules targeting other CDKs as per the DelveInsight’s...