Oncology

Targeted therapy is the most preferred option for cancer treatment and a number of new targets are being discovered which target cancer specific receptors, AKT being one of them. Protein kinase B (PKB), also known as AKT, belongs to serine/threonine protein kinase superfamily. AKT has been validated as a potential target as it plays a central role in many types of cancer, and studies have proven that the AKT signaling cascade is frequently impaired in many types of cancer and, in some cases; it is associated with tumor aggressiveness. Also, AKT/PI3K pathway is an important signal transduction pathway and it has been observed that PI3K is overexpressed in ovarian and ce...