WVE-007 is a GalNAc-conjugated small interfering RNA (siRNA) designed to target the messenger RNA of the INHBE gene, which encodes the liver-derived protein Activin E. Activin E suppresses fat breakdown (lipolysis) by acting directly on adipose tissue. By silencing INHBE, WVE-007 aims to remove this metabolic block and restore the body’s natural fat-burning processes.
In preclinical studies using a Diet-induced Obesity (DIO) mouse model, WVE-007 showed promise across various therapeutic scenarios—both as a standalone treatment, in combination with GLP-1 therapies, and as a maintenance option to help sustain weight loss after stopping GLP-1 therapy.
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