Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand (Apo2L) is a type II trans membrane protein belonging to the Tumor Necrosis Factor (TNF) superfamily that are widely expressed on the surface of Natural Killer (NK) and T cells, macrophages and dendrite cells.
These proteins bind to the Death receptor 4 (DR4) and 5 (DR5), and trigger apoptosis in tumor cells. Discovery of TRAIL proteins and its receptors came as a promising therapeutic approach in anti-cancer target therapies because of its unique quality of binding to variety of tumor cells while sparing the normal vital cells of the body. Unfortunately, first generation...
