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Gender matters for Party drug Ketamine to work its anti-depressant activity in mice Experiments involving the popular party drug ketamine, a psychoactive recreational drug used to uplift mood of the user, in mice has deepened the mystery of how the dug affects the brain further. Results of a study conducted at the University of Maryland has raised questions about the reproducibility of behavioral experiments in mice. Polymnia Georgiou, a neuroscientist at the University of Maryland in Baltimore conducted an experiment of ketamine on mice as a favour to a male colleague, including a standard way of testing antidepressants, called the forced-swim test. In this assay, res...