Neuromyelitis Optica Spectrum Disorder - Market Insights, Epidemiology and Market Forecast-2027

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Geography: Global
Delivery Timeline: 48 hrs
Publication: Dec, 2018

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DelveInsight’s ‘Neuromyelitis Optica Spectrum Disorder (NMOSD) - Market Insights, Epidemiology and Market Forecast-2027’ report delivers an in-depth understanding of the disease, historical & forecasted epidemiology as well as the market trends of NMOSD in the United States, EU5 (Germany, Spain, Italy, France and United Kingdom), and Japan.
The Report provides the current treatment practices, emerging drugs, market share of the individual therapies, current and forecasted market size of NMOSD from 2016 to 2027 segmented by seven major markets. The Report also covers current treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assess underlying potential of the market.

Geography Covered

• The United States

• EU5 (Germany, France, Italy, Spain and the United Kingdom)

• Japan

Study Period: 2016-2027

Neuromyelitis Optica Spectrum Disorder (NMOSD) - Disease Understanding and Treatment Algorithm

The DelveInsight Neuromyelitis Optica Spectrum Disorder market report gives the thorough understanding of the Neuromyelitis Optica Spectrum Disorder by including details such as disease definition, classification, symptoms, etiology, pathophysiology, diagnostic trends. It also provides treatment algorithms and treatment guidelines for Neuromyelitis Optica Spectrum Disorder in the US, Europe, and Japan.

Neuromyelitis Optica Spectrum Disorder Epidemiology

The Neuromyelitis Optica Spectrum Disorder epidemiology division provide the insights about historical and current patient pool and forecasted trend for every 7 major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed and treatable patient pool and their trends along with assumptions undertaken.
The disease epidemiology covered in the report is segmented by prevalent population, gender- specific [Male and Female] and NMO-IgG Diagnosed Cases [NMO-IgG Seropositive and NMO-IgG Seronegative] and Clinical Characterization (Transverse Myelitis, Longitudinally extensive TM, Focal TM, Optic Neuritis, Unilateral ON, and Bilateral ON).
According to DelveInsight, the prevalent cases of NMOSD was 32,382 in 2016 in 7 MM and, is expected to increase at a CAGR of XX% during the study period i.e., 2016-2027. Among 7MM, United States account for highest prevalent cases of NMOSD with 16,000 prevalent cases in 2016.

Neuromyelitis Optica Spectrum Disorder Drug Chapters

This segment of the Neuromyelitis Optica Spectrum Disorder report encloses the detailed analysis of marketed drugs and late stage (Phase-III) pipeline drugs. It also helps to understand the clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases. This report includes detailed chapters of promising upcoming therapies.

Neuromyelitis Optica Spectrum Disorder Market Outlook

The Neuromyelitis Optica Spectrum Disorder market outlook of the report helps to build the detailed comprehension of the historic, current and forecasted trend of the market by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.
This segment gives a through detail of market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
NMOSD market is expected to grow during the forecasted period of 2018-2027 at a CAGR of XX% owing to the launch of few drugs (presently in Phase III and Phase II). NMOSD therapeutics market has seen a 7MM sales of USD 145.1 million in 2016.

Neuromyelitis Optica Spectrum Disorder Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the market or will get launched in the market during the study period from 2016-2027. The analysis covers market uptake by drugs; patient uptake by therapies and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Neuromyelitis Optica Spectrum Disorder Report Insights

• Patient Population

• Therapeutic Approaches

• Pipeline Analysis

• Market Size and Trends

• Market Opportunities

• Impact of upcoming Therapies

Neuromyelitis Optica Spectrum Disorder Report Key Strengths

• 10 Year Forecast

• 7MM Coverage

• Epidemiology Segmentation

• Drugs Uptake

• Highly Analyzed Market

• Key Cross Competition

Neuromyelitis Optica Spectrum Disorder Report Assessment

• Current Treatment Practices

• Unmet Needs

• Detailed Pipeline Product Profiles

• Market Attractiveness

• Market Drivers and Barriers

Key Benefits

• This DelveInsight report will help to develop Business Strategies by understanding the trends shaping and driving the Neuromyelitis Optica Spectrum Disorder market

• Organize sales and marketing efforts by identifying the best opportunities for Neuromyelitis Optica Spectrum Disorder market

• To understand the future market competition in the Neuromyelitis Optica Spectrum Disorder market.

1. Key Insights
2. Neuromyelitis Optica Spectrum Disorder: Market Overview at a Glance
2.1. Total Market Share (%) Distribution of Neuromyelitis Optica Spectrum Disorder in 2017
2.2. Total Market Share (%) Distribution of Neuromyelitis Optica Spectrum Disorder in 2027
3. Neuromyelitis Optica Spectrum Disorder: Disease Background and Overview
3.1. Introduction
3.2. Signs and Symptoms
3.3. Clinical features of NMO/NMOSD
3.4. Classification
3.5. Pathogenesis
3.6. Diagnosis
3.7. International consensus diagnostic criteria for Neuromyelitis Optica Spectrum Disorders
3.8. Neuroimaging and neurophysiologic testing
3.8.1. Considerations for AQP4-IgG serologic and another laboratory testing.
3.8.2. Pediatric NMOSD criteria
3.8.3. Monophasic NMOSD
3.8.4. Systemic autoimmunity associated with NMOSD.
3.8.5. Pathology
3.8.6. Opticospinal MS
4. Epidemiology and Patient Population
4.1. Key Findings
5. 7MM Total Prevalent Patient Population of NMO/NMOSD
6. Country Wise-Epidemiology of NMO/NMOSD
6.1. United States
6.1.1. Assumptions and Rationale
6.1.2. Total Prevalent Population of NMO/NMOSD
6.1.3. Gender-Specific Prevalent Population of NMO/NMOSD
6.1.4. Total Diagnosed Population of NMO/NMOSD
6.1.5. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.1.6. Clinical Characterization of NMO/NMOSD
6.1.7. Events of NMO/NMOSD
6.2. EU5 Countries
6.2.1. Assumptions and Rationale
6.3. Germany
6.3.1. Total Prevalent Population of NMO/NMOSD
6.3.2. Gender-Specific Prevalent Population of NMO/NMOSD
6.3.3. Total Diagnosed Population of NMO/NMOSD
6.3.4. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.3.5. Clinical Characterization of NMO/NMOSD
6.3.6. Events of NMO/NMOSD
6.4. France
6.4.1. Total Prevalent Population of NMO/NMOSD
6.4.2. Gender-Specific Prevalent Population of NMO/NMOSD
6.4.3. Total Diagnosed Population of NMO/NMOSD
6.4.4. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.4.5. Clinical Characterization of NMO/NMOSD
6.4.6. Events of NMO/NMOSD
6.5. Italy
6.5.1. Total Prevalent Population of NMO/NMOSD
6.5.2. Gender-Specific Prevalent Population of NMO/NMOSD
6.5.3. Total Diagnosed Population of NMO/NMOSD
6.5.4. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.5.5. Clinical Characterization of NMO/NMOSD
6.5.6. Events of NMO/NMOSD
6.6. United Kingdom
6.6.1. Total Prevalent Population of NMO/NMOSD
6.6.2. Gender-Specific Prevalent Population of NMO/NMOSD
6.6.3. Total Diagnosed Population of NMO/NMOSD
6.6.4. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.6.5. Clinical Characterization of NMO/NMOSD
6.6.6. Events of NMO/NMOSD
6.7. Spain
6.7.1. Total Prevalent Population of NMO/NMOSD
6.7.2. Gender-Specific Prevalent Population of NMO/NMOSD
6.7.3. Total Diagnosed Population of NMO/NMOSD
6.7.4. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.7.5. Clinical Characterization of NMO/NMOSD
6.7.6. Events of NMO/NMOSD
6.8. Japan
6.8.1. Assumptions and Rationale
6.8.2. Total Prevalent Population of NMO/NMOSD
6.8.3. Gender-Specific Prevalent Population of NMO/NMOSD
6.8.4. Total Diagnosed Population of NMO/NMOSD
6.8.5. NMO-IgG Diagnosed Cases of NMO/NMOSD
6.8.6. Clinical Characterization of NMO/NMOSD
6.8.7. Events of NMO/NMOSD
7. Treatment
7.1. Treatment Algorithm
7.1.1. Treatment of Acute Attacks
7.1.2. Preventive Treatment of Relapse
7.2. Treatment Guidelines Country wise
7.2.1. American College of Chest Physicians Task Force
7.2.2. The European Federation of Neurological Societies
8. Unmet Needs
9. Key Cross Competitors
10. Emerging Drugs
10.1. MEDI-551: Viela Bio
10.1.1. Drug Description
10.1.2. Regulatory Milestones
10.1.3. Clinical Development
10.1.4. Product Profile
10.2. Satralizumab (SA237): Chugai Pharmaceutical/ Roche
10.2.1. Drug Description
10.2.2. Regulatory Milestones
10.2.3. Clinical Development
10.2.4. Product Profile
10.3. Soliris: Alexion Pharma
10.3.1. Drug Description
10.3.2. Regulatory Milestones
10.3.3. Clinical Development
10.3.4. Safety and Efficacy
10.3.5. Product Profile
11. Neuromyelitis Optica: 7 Major Market Analysis
11.1. Key Findings
11.2. Market Size of NMO/NMOSD in 7MM
12. United States Market Outlook
12.1. United States Market Size
12.1.1. Total Market size of NMO/NMOSD
12.1.2. Market size of NMO/NMOSD based on Types
12.1.3. Market Size by Therapies
13. EU-5 Countries: Market Outlook
13.1. Germany
13.1.1. Total Market size of NMO/NMOSD
13.1.2. Market size of NMO/NMOSD based on Types
13.1.3. Market Size by Therapies
13.2. France
13.2.1. Total Market size of NMO/NMOSD
13.2.2. Market size of NMO/NMOSD based on Types
13.2.3. Market Size by Therapies
13.3. Italy
13.3.1. Total Market size of NMO/NMOSD
13.3.2. Market size of NMO/NMOSD based on Types
13.3.3. Market Size by Therapies
13.4. United Kingdom
13.4.1. Total Market size of NMO/NMOSD
13.4.2. Market size of NMO/NMOSD based on Types
13.4.3. Market Size by Therapies
13.5. Spain
13.5.1. Total Market size of NMO/NMOSD
13.5.2. Market size of NMO/NMOSD based on Types
13.5.3. Market Size by Therapies
14. Japan: Market Outlook
14.1. Japan Market Size
14.1.1. Total Market size of NMO/NMOSD
14.1.2. Market size of NMO/NMOSD based on Types
14.1.3. Market Size by Therapies
15. Market Drivers
16. Market Barriers
17. Appendix
17.1. Report Methodology
18. DelveInsight Capabilities
19. Disclaimer
20. About DelveInsight

Table 1: Signs and Symptoms of Neuromyelitis Optica
Table 2: Brain symptoms in Neuromyelitis Optica
Table 3: NMOSD diagnostic criteria for adult patients
Table 4: Red flags: Findings atypical for NMOSD
Table 5: Neuroimaging characteristics of NMOSD
Table 6: Total Prevalent Population of NMO/NMOSD in the 7MM (2016-2027)
Table 7: Total Prevalent Population of NMO/NMOSD in the US (2016-2027)
Table 8: Gender Specific Prevalence of NMO/NMOSD in the US (2016-2027)
Table 9: Diagnosed Cases of Neuromyelitis Optica in the US (2016-2027)
Table 10: NMO-IgG Diagnosed Cases of NMO/NMOSD in the US (2016-2027)
Table 11: Clinical Characterization of NMO/NMOSD in the US (2016-2027)
Table 12: Events of NMO/NMOSD in the US (2016-2027)
Table 13: Total Prevalent Population of NMO/NMOSD in Germany (2016-2027)
Table 14: Gender Specific Prevalence of NMO/NMOSD in Germany (2016-2027)
Table 15: Diagnosed Cases of Neuromyelitis Optica in Germany (2016-2027)
Table 16: NMO-IgG Diagnosed Cases of NMO/NMOSD in Germany (2016-2027)
Table 17: Clinical Characterization of NMO/NMOSD in Germany (2016-2027)
Table 18: Events of NMO/NMOSD in Germany (2016-2027)
Table 19: Total Prevalent Population of NMO/NMOSD in France (2016-2027)
Table 20: Gender Specific Prevalence of NMO/NMOSD in France (2016-2027)
Table 21: Diagnosed Cases of Neuromyelitis Optica in France (2016-2027)
Table 22: NMO-IgG Diagnosed Cases of NMO/NMOSD in France (2016-2027)
Table 23: Clinical Characterization of NMO/NMOSD in France (2016-2027)
Table 24: Events of NMO/NMOSD in France (2016-2027)
Table 25: Total Prevalent Population of NMO/NMOSD in Italy (2016-2027)
Table 26: Gender Specific Prevalence of NMO/NMOSD in Italy (2016-2027)
Table 27: Diagnosed Cases of Neuromyelitis Optica in Italy (2016-2027)
Table 28: NMO-IgG Diagnosed Cases of NMO/NMOSD in Italy (2016-2027)
Table 29: Clinical Characterization of NMO/NMOSD in Italy (2016-2027)
Table 30: Events of NMO/NMOSD in Italy (2016-2027)
Table 31: Total Prevalent Population of NMO/NMOSD in The UK (2016-2027)
Table 32: Gender Specific Prevalence of NMO/NMOSD in The UK (2016-2027)
Table 33: Diagnosed Cases of Neuromyelitis Optica in The UK (2016-2027)
Table 34: NMO-IgG Diagnosed Cases of NMO/NMOSD in the UK (2016-2027)
Table 35: Clinical Characterization of NMO/NMOSD in The UK (2016-2027)
Table 36: Events of NMO/NMOSD in The UK (2016-2027)
Table 37: Total Prevalent Population of NMO/NMOSD in Spain (2016-2027)
Table 38: Gender Specific Prevalence of NMO/NMOSD in Spain (2016-2027)
Table 39: Diagnosed Cases of Neuromyelitis Optica in Spain (2016-2027)
Table 40: NMO-IgG Diagnosed Cases of NMO/NMOSD in Spain (2016-2027)
Table 41: Clinical Characterization of NMO/NMOSD in Spain (2016-2027)
Table 42: Events of NMO/NMOSD in Spain (2016-2027)
Table 43: Total Prevalent Population of NMO/NMOSD in Japan (2016-2027)
Table 44: Gender Specific Prevalence of NMO/NMOSD in Japan (2016-2027)
Table 45: Diagnosed Cases of Neuromyelitis Optica in Japan (2016-2027)
Table 46: NMO-IgG Diagnosed Cases of NMO/NMOSD in Japan (2016-2027)
Table 47: Clinical Characterization of NMO/NMOSD in Japan (2016-2027)
Table 48: Events of NMO/NMOSD in Japan (2016-2027)
Table 49: Grading Recommendations for Neuromyelitis Optica
Table 50: Summary of treatments and recommendation levels used for Neuromyelitis Optica
Table 51: MEDI-551, Clinical Trial Description, 2018
Table 52: Satralizumab, Clinical Trial Description, 2018
Table 53: Eculizumab, Clinical Trial Description, 2018
Table 54: 7 Major Market Size of NMO/NMOSD in USD Million (2016-2027)
Table 55: Market Size of NMO/NMOSD in the US, USD Million (2016-2027)
Table 56: Market Size of NMO/NMOSD based on types in the US, USD Million (2016-2027)
Table 57: Market size of NMO/NMOSD by therapies in the US, in USD Million (2016-2027)
Table 58: Market Size of NMO/NMOSD in Germany, USD Million (2016-2027)
Table 59: Market Size of NMO/NMOSD based on types in Germany, USD Million (2016-2027)
Table 60: Market size of NMO/NMOSD by therapies in Germany, in USD Million (2016-2027)
Table 61: Market Size of NMO/NMOSD in France, USD Million (2016-2027)
Table 62: Market Size of NMO/NMOSD based on types in France, USD Million (2016-2027)
Table 63: Market size of NMO/NMOSD by therapies in France, in USD Million (2016-2027)
Table 64: Market Size of NMO/NMOSD in Italy, USD Million (2016-2027)
Table 65: Market Size of NMO/NMOSD based on types in Italy, USD Million (2016-2027)
Table 66: Market size of NMO/NMOSD by therapies in Italy, in USD Million (2016-2027)
Table 67: Market Size of NMO/NMOSD in the UK, USD Million (2016-2027)
Table 68: Market Size of NMO/NMOSD based on types in the UK, USD Million (2016-2027)
Table 69: Market size of NMO/NMOSD by therapies in the UK, in USD Million (2016-2027)
Table 70: Market Size of NMO/NMOSD in Spain, USD Million (2016-2027)
Table 71: Market Size of NMO/NMOSD based on types in Spain, USD Million (2016-2027)
Table 72: Market size of NMO/NMOSD by therapies in Spain, in USD Million (2016-2027)
Table 73: Market Size of NMO/NMOSD in Japan, USD Million (2016-2027)
Table 74: Market Size of NMO/NMOSD based on types in Japan, USD Million (2016-2027)
Table 75: Market size of NMO/NMOSD by therapies in Japan, in USD Million (2016-2027)

Figure 1: Signs and symptoms of NMO/NMOSD
Figure 2: Clinical features of NMO/NMOSD
Figure 3: Neuromyelitis Optica Pathogenesis
Figure 4: Total Prevalent Patient Population of NMO/NMOSD in the 7MM (2016-2027)
Figure 5: Total Prevalent Population of NMO/NMOSD in the US (2016-2027)
Figure 6: Gender Specific Prevalence of NMO/NMOSD in the US (2016-2027)
Figure 7: Diagnosed Cases of NMO/NMOSD in the US (2016-2027)
Figure 8: NMO-IgG Diagnosed Cases of NMO/NMOSD in the US (2016-2027)
Figure 9: Clinical Characterization of NMO/NMOSD in the US (2016-2027)
Figure 10: Events of NMO/NMOSD in the US (2016-2027)
Figure 11: Total Prevalent Population of NMO/NMOSD in Germany (2016-2027)
Figure 12: Gender Specific Prevalence of NMO/NMOSD in Germany (2016-2027)
Figure 13: Diagnosed Cases of NMO/NMOSD in Germany (2016-2027)
Figure 14: NMO-IgG Diagnosed Cases of NMO/NMOSD in Germany (2016-2027)
Figure 15: Clinical Characterization of NMO/NMOSD in Germany (2016-2027)
Figure 16: Events of NMO/NMOSD in Germany (2016-2027)
Figure 17: Total Prevalent Population of NMO/NMOSD in France (2016-2027)
Figure 18: Gender Specific Prevalence of NMO/NMOSD in France (2016-2027)
Figure 19: Diagnosed Cases of NMO/NMOSD in France (2016-2027)
Figure 20: NMO-IgG Diagnosed Cases of NMO/NMOSD in France (2016-2027)
Figure 21: Clinical Characterization of NMO/NMOSD in France (2016-2027)
Figure 22: Events of NMO/NMOSD in France (2016-2027)
Figure 23: Total Prevalent Population of NMO/NMOSD in Italy (2016-2027)
Figure 24: Gender Specific Prevalence of NMO/NMOSD in Italy (2016-2027)
Figure 25: Diagnosed Cases of NMO/NMOSD in Italy (2016-2027)
Figure 26: NMO-IgG Diagnosed Cases of NMO/NMOSD in Italy (2016-2027)
Figure 27: Clinical Characterization of NMO/NMOSD in Italy (2016-2027)
Figure 28: Events of NMO/NMOSD in Italy (2016-2027)
Figure 29: Total Prevalent Population of NMO/NMOSD in The UK (2016-2027)
Figure 30: Gender Specific Prevalence of NMO/NMOSD in The UK (2016-2027)
Figure 31: Diagnosed Cases of NMO/NMOSD in The UK (2016-2027)
Figure 32: NMO-IgG Diagnosed Cases of NMO/NMOSD in the UK (2016-2027)
Figure 33: Clinical Characterization of NMO/NMOSD in The UK (2016-2027)
Figure 34: Events of NMO/NMOSD in The UK (2016-2027)
Figure 35: Total Prevalent Population of NMO/NMOSD in Spain (2016-2027)
Figure 36: Gender Specific Prevalence of NMO/NMOSD in Spain (2016-2027)
Figure 37: Diagnosed Cases of NMO/NMOSD in Spain (2016-2027)
Figure 38: NMO-IgG Diagnosed Cases of NMO/NMOSD in Spain (2016-2027)
Figure 39: Clinical Characterization of NMO/NMOSD in Spain (2016-2027)
Figure 40: Events of NMO/NMOSD in Spain (2016-2027)
Figure 41: Total Prevalent Population of NMO/NMOSD in Japan (2016-2027)
Figure 42: Gender Specific Prevalence of NMO/NMOSD in Japan (2016-2027)
Figure 43: Diagnosed Cases of NMO/NMOSD in Japan (2016-2027)
Figure 44: NMO-IgG Diagnosed Cases of NMO/NMOSD in Japan (2016-2027)
Figure 45: Clinical Characterization of NMO/NMOSD in Japan (2016-2027)
Figure 46: Events of NMO/NMOSD in Japan (2016-2027)
Figure 47: Treatment Algorithm of Neuromyelitis Optica
Figure 48: Unmet Needs of Neuromyelitis Optica
Figure 49: 7 Major Market Size of NMO/NMOSD in USD Million (2016-2027)
Figure 50: Market Size of NMO/NMOSD in the US, USD Million (2016-2027)
Figure 51: Market Size of NMO/NMOSD based on types in the US, USD Million (2016-2027)
Figure 52: Market size of NMO/NMOSD by therapies in the US, in USD Million (2016-2027)
Figure 53: Market Size of NMO/NMOSD in Germany, USD Million (2016-2027)
Figure 54: Market Size of NMO/NMOSD based on types in Germany, USD Million (2016-2027)
Figure 55: Market size of NMO/NMOSD by therapies in Germany, in USD Million (2016-2027)
Figure 56: Market Size of NMO/NMOSD in France, USD Million (2016-2027)
Figure 57: Market Size of NMO/NMOSD based on types in France, USD Million (2016-2027)
Figure 58: Market size of NMO/NMOSD by therapies in France, in USD Million (2016-2027)
Figure 59: Market Size of NMO/NMOSD in Italy, USD Million (2016-2027)
Figure 60: Market Size of NMO/NMOSD based on types in Italy, USD Million (2016-2027)
Figure 61: Market size of NMO/NMOSD by therapies in Italy, in USD Million (2016-2027)
Figure 62: Market Size of NMO/NMOSD in the UK, USD Million (2016-2027)
Figure 63: Market Size of NMO/NMOSD based on types in the UK, USD Millions (2016-2027)
Figure 64: Market size of NMO/NMOSD by therapies in the UK, in USD Million (2016-2027)
Figure 65: Market Size of NMO/NMOSD in Spain, USD Million (2016-2027)
Figure 66: Market Size of NMO/NMOSD based on types in Spain, USD Million (2016-2027)
Figure 67: Market size of NMO/NMOSD by therapies in Spain, in USD Million (2016-2027)
Figure 68: Market Size of NMO/NMOSD in Japan, USD Million (2016-2027)
Figure 69: Market Size of NMO/NMOSD based on types in Japan, USD Million (2016-2027)
Figure 70: Market size of NMO/NMOSD by therapies in Japan, in USD Million (2016-2027)
Figure 71: Market Drivers
Figure 72: Market Barriers