Articles

Primary Sjögren syndrome (pSS) is a.prototypical autoimmune.disease. The involvement.of B cells in the pathogenesis.of pSS has long been suspected.on the basis of clinical.observations that include the.presence of serum.autoantibodies, hypergammaglobulinemia, increased.levels of free light chains and.increased risk of B cell lymphoma. Moreover, the.composition of the B cell subset is.altered in Primary Sjögren syndrome. The researchers have discussed about.the mechanisms that support the.increased activation of B cells in pSS, including genetic.and epigenetic factors and environmental.triggers that promote B cell activation via the.innate immune system. B cell activati...